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Hypoxia regulates vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts.

Abstract：

OBJECTIVE:To evaluate the effect of hypoxia on the production of vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) in the human fallopian tube. DESIGN:The secretion of VEGF and sFlt-1 by cultured oviductal epithelial cells (OECs) and oviductal stromal fibroblasts (OSFs) in response to hypoxia was investigated. SETTING:Research laboratory at a medical school. PATIENT(S):Normal oviducts obtained from seven premenopausal patients were used. INTERVENTION(S):Oviductal epithelial cells and OSFs were incubated under normoxic (20% O2) or hypoxic (2% O2) conditions. MAIN OUTCOME MEASURE(S):The concentrations of VEGF and sFlt-1 in the culture media of OECs and OSFs were measured by enzyme-linked immunosorbent assays. RESULT(S):The secretion of both VEGF and sFlt-1 was detected in cultured OECs and OSFs and was found to have been stimulated under hypoxic conditions in these cells. CONCLUSION(S):The present findings suggest that hypoxia in the local environment may stimulate oviductal vascular permeability by inducing the production of VEGF by oviductal cells. Simultaneous up-regulation of sFlt-1 secretion by these cells under hypoxic conditions may prevent excessive up-regulation of vascular permeability. The modulation of the bias of VEGF and sFlt-1 in the fallopian tubes may contribute to the normal and pathological processes of oviductal fluid secretion by regulating oviductal vascular permeability during the menstrual cycle.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Itoh H,Nasu K,Matsumoto H,Kawano Y,Yoshimatsu J,Narahara H

doi

10.1016/j.fertnstert.2005.10.023

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

1097-102

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(05)04187-7

journal_volume

85 Suppl 1

pub_type

杂志文章

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