Surrogate end points in women's health research: science, protoscience, and pseudoscience.

abstract：OBJECTIVE:To present four cases of twin tubal pregnancies and discuss possible etiologies. Twin tubal pregnancies are a rare event, with incidence rates estimated as 1 out of 725-1,580 of tubal pregnancies. DESIGN:Case series. SETTING:Department of obstetrics and gynecology at a tertiary health care facility. PATIEN...

journal_title：Fertility and sterility

authors： Svirsky R,Maymon R,Vaknin Z,Mendlovic S,Weissman A,Halperin R,Herman A,Pansky M

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:To determine the rearrangement of mitochondrial DNA (mtDNA) in unfertilized human oocytes and compromised embryos to evaluate the fertilization capacity of oocytes. DESIGN:Prospective laboratory research. SETTING:IVF laboratory in a university hospital. PATIENT(S):One hundred twenty-four unfertilized oocyt...

journal_title：Fertility and sterility

authors： Hsieh RH,Tsai NM,Au HK,Chang SJ,Wei YH,Tzeng CR

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:To assess the effect of human recombinant leukemia inhibitory factor in different doses on human blastocyst formation. SETTING:A university-based tertiary referral center (The Toronto Hospital). INTERVENTIONS:Nontransferable human embryos (n = 473) at the two- to six-cell stage were obtained from patients u...

journal_title：Fertility and sterility

authors： Jurisicova A,Ben-Chetrit A,Varmuza SL,Casper RF

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:To evaluate the effects of resveratrol on growth and function of granulosa cells. Previously, we demonstrated that resveratrol exerts profound proapoptotic effects on theca-interstitial cells. DESIGN:In vitro study. SETTING:Research laboratory. ANIMAL(S):Immature Sprague-Dawley female rats. INTERVENTION(S...

journal_title：Fertility and sterility

authors： Ortega I,Wong DH,Villanueva JA,Cress AB,Sokalska A,Stanley SD,Duleba AJ

更新日期：2012-12-01 00:00:00

abstract：:Twelve patients with amenorrhea-galactorrhea and hyperprolactinemia are presented. The mean serum prolactin level was 175 ng/ml (range, 37 to 575 ng/ml). Basal gonadotropin levels were normal in all patients. Serum estradiol levels were normal in three women and reduced in nine. The response to luteinizing hormone-rel...

journal_title：Fertility and sterility

authors： Floersheim-Shachar Y,Keller PJ

更新日期：1977-11-01 00:00:00

abstract：:Women who exercise heavily may develop secondary amenorrhea. Since the mechanism of so-called "runner's amenorrhea" has not been conclusively established, the authors examined the occurrence of amenorrhea in one of the most intensively exercising groups of female runners in the United States (average, 70 miles/week): ...

journal_title：Fertility and sterility

authors： Glass AR,Deuster PA,Kyle SB,Yahiro JA,Vigersky RA,Schoomaker EB

更新日期：1987-11-01 00:00:00

abstract：:The purpose of this study was to determine whether routine prolactin measurement was of use when investigating men with infertility. Prolactin levels were slightly higher in men with primary infertility, compared with men with secondary infertility and a fertile control group. Although this slight increase was statist...

journal_title：Fertility and sterility

authors： Hargreave TB,Richmond JD,Liakatas J,Elton RA,Brown NS

更新日期：1981-11-01 00:00:00

abstract：OBJECTIVE:To compare sperm characteristics among: patients undergoing infertility evaluation, patients with male factor infertility (MFI), healthy sperm donors, and men with proven fertility; to examine the overlap of sperm characteristics in all four of these groups; and to identify good discriminators of fertility ve...

journal_title：Fertility and sterility

authors： Nallella KP,Sharma RK,Aziz N,Agarwal A

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the remodeling of large arteries according to age at menopause, duration of menopause, and use of hormone therapy (HT). DESIGN:A cross-sectional study consisting of baseline measurements of a multicentric randomized trial were used to evaluate arterial parameters. SETTING:The study was conducted...

journal_title：Fertility and sterility

authors： Gompel A,Boutouyrie P,Joannides R,Christin-Maitre S,Kearny-Schwartz A,Kunz K,Laurent S,Boivin JM,Pannier B,Pornel B,Struijker-Boudier HA,Thuillez C,Van Bortel L,Zannad F,Pithois-Merli I,Jaillon P,Simon T

更新日期：2011-12-01 00:00:00

abstract：:The study and treatment of luteal phase defect since the late 1940s, particularly the work of Georgeanna Seegar Jones, are summarized. ...

journal_title：Fertility and sterility

authors： Jones HW Jr

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:To evaluate semen characteristics, testicular volume, and hormonal levels of normal fertile men requiring vasectomy for sterilization. DESIGN:Retrospective study. SETTING(S):Academic medical centers. PATIENT(S):A total of 889 patients underwent a vasectomy for sterilization. INTERVENTION(S):None. MAIN OU...

journal_title：Fertility and sterility

authors： Pasqualotto FF,Sobreiro BP,Hallak J,Athayde KS,Pasqualotto EB,Lucon AM

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:To characterize the BET gene expression in human testis with spermatogenetic impairments; to examine BRDT protein expression in testis and semen. DESIGN:Prospective study. SETTING:Fertility clinic. PATIENT(S):Azoospermic men (n = 120) who underwent testicular sperm extraction and who were classified as eit...

journal_title：Fertility and sterility

authors： Barda S,Paz G,Yogev L,Yavetz H,Lehavi O,Hauser R,Botchan A,Breitbart H,Kleiman SE

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To determine association between health-related quality of life (HRQOL) and psychosexual variables in patients with polycystic ovary syndrome (PCOS). DESIGN:Cross-sectional study. SETTING:Two private gynecology clinics. PATIENT(S):A sample of 300 women with PCOS were entered into the study and were subdivi...

journal_title：Fertility and sterility

authors： Bazarganipour F,Ziaei S,Montazeri A,Foroozanfard F,Kazemnejad A,Faghihzadeh S

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:To determine whether progestins activate vascular endothelial growth factor (VEGF) gene transcription in endometrial adenocarcinoma cells. DESIGN:In vitro study. SETTING:University reproductive biology laboratories. PATIENT(S):None. INTERVENTION(S):Ishikawa cells were transfected with VEGF promoter-lucife...

journal_title：Fertility and sterility

authors： Mueller MD,Vigne JL,Pritts EA,Chao V,Dreher E,Taylor RN

更新日期：2003-02-01 00:00:00

abstract：:Transvaginal follicular aspiration (TVA) with ultrasonically guided needles allows the transfer of in vitro generated embryos to the fallopian tubes (TET), performing only one surgical procedure in the process. Up to now, this approach has been used to treat 16 couples with infertility due to severe male factor. Folli...

journal_title：Fertility and sterility

authors： Balmaceda JP,Gastaldi C,Remohi J,Borrero C,Ord T,Asch RH

更新日期：1988-09-01 00:00:00

abstract：OBJECTIVE:To evaluate basal (constitutive) and stimulated synthesis of tumor necrosis factor alpha (TNF alpha), interleukin (IL)-8, IL-10 by peritoneal macrophages (PM) in women with endometriosis. DESIGN:Peritoneal macrophages were cultured in the presence or absence of lipopolysaccharide (LPS) for 24 hours. Peritone...

journal_title：Fertility and sterility

authors： Rana N,Braun DP,House R,Gebel H,Rotman C,Dmowski WP

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVE:To report an unusual case of embryo implantation and superfetation. DESIGN:Retrospective case analysis. SETTING:Oak Brook Fertility Center. PATIENT(S):A 41-year-old woman underwent two consecutive ovarian stimulation cycles interrupted by a normal menstrual period. Ovulation and implantation occurred durin...

journal_title：Fertility and sterility

authors： Dmowski WP,DeOrio L,Rana N

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:To determine the prevalence of compound genetic abnormalities in patients who are carriers of cystic fibrosis mutations. DESIGN:Case report. SETTING:Tertiary referral center for male infertility. PATIENT(S):Between 2000 and 2005, 65 patients were identified to be carriers of cystic fibrosis transmembrane r...

journal_title：Fertility and sterility

authors： Karpman E,Williams DH 4th,Wilberforce S,Lipshultz LI

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:To investigate the ability of N-formyl-methionyl-leucyl-phenylalanine (f-MLP), complement 5a (C5a), and nerve growth factor (NGF) to stimulate human spermatozoal reactive oxygen species generation in fertile and infertile patients. DESIGN:Prospective, controlled study measuring human spermatozoal reactive ox...

journal_title：Fertility and sterility

authors： Weese DL,Peaster ML,Hernandez RD,Leach GE,Lad PM,Zimmern PE

更新日期：1993-04-01 00:00:00

abstract：:To investigate the mechanism of the antifertility action of sulfasalazine, we prospectively measured sperm density, motility, hamster oocyte penetration capacity, and reactive oxygen species production in six men with inflammatory bowel disease being treated with sulfasalazine and 8 and 16 weeks after changing to 5-am...

journal_title：Fertility and sterility

authors： Wu FC,Aitken RJ,Ferguson A

更新日期：1989-11-01 00:00:00

abstract：OBJECTIVE:To determine whether serum interleukin (IL)-8 concentration can be measured in patients with ovarian endometrioma and whether this measurement is a useful tool in diagnosing this disease. DESIGN:A controlled clinical study and an in vitro study. SETTING:Department of Obstetrics and Gynecology, Tottori Unive...

journal_title：Fertility and sterility

authors： Ohata Y,Harada T,Miyakoda H,Taniguchi F,Iwabe T,Terakawa N

更新日期：2008-10-01 00:00:00

abstract：:A study was undertaken to examine the influence of pH on the migration of X and Y sperm as observed in freshly ejaculated semen samples from human donors. These sperm were allowed to migrate into capillary tubes containing media of varying pH. Y-carrying sperm were i dentified using flourescent staining with quinacr...

journal_title：Fertility and sterility

authors： Diasio RB,Glass RH

更新日期：1971-05-01 00:00:00

abstract：:Human testes, removed in treating patients for prostatic carcinoma, were used. Tissues were homogenized and incubated in vitro with labeled progesterone and 2 different antiovulatories, lynestrenol (17alpha-ethin yl-17beta-hydroxy-estr-4-one) and MK 665 (17alpha-chloroethinyl-19-nor-4 ,9(10)-androstadiene-17beta-ol-...

journal_title：Fertility and sterility

authors： Balatti JJ,Claret A,Rosner JM

更新日期：1967-05-01 00:00:00

abstract：OBJECTIVE:To present a case report of a spontaneous, heterotopic, triplet conception of a patient without any risk factors. DESIGN:Case report. SETTING:Community hospital in Park Ridge, Illinois. PATIENT(S):One patient, 30-year-old multigravida, sent to the emergency room for evaluation of right lower quadrant pain ...

journal_title：Fertility and sterility

authors： Cholkeri-Singh A,LaBarge A

更新日期：2007-10-01 00:00:00

abstract：:Hysteroscopic visualization of the endometrium after 6 months of antitubercular therapy showed an improvement in the mucosal morphology. A closer visualization at increased magnification was helpful in demonstrating the remnants of a healing tubercular pathology after antitubercular therapy. ...

journal_title：Fertility and sterility

authors： Kumar A,Kumar A

更新日期：2008-03-01 00:00:00

abstract：:We hypothesized that diminished endothelin 1 (ET-1) expression at the spermatic vein wall level might be responsible for the development of varicocele. However, immunohistochemical evaluation of spermatic and control vein samples from 55 patients with varicocele showed overexpression of ET-1 and its receptors ETA and ...

journal_title：Fertility and sterility

authors： Gyftopoulos K,Chondrogianni C,Papadaki H

更新日期：2011-06-30 00:00:00

abstract：OBJECTIVE:To evaluate the benefit of Y microdeletion testing. DESIGN:Retrospective analysis. SETTING:University-based male fertility clinic and genetics laboratory. PATIENT(S):A total of 1,591 men with sperm concentrations less than 5 million sperm/mL. INTERVENTION(S):Semen analysis, Y microdeletion testing, microd...

journal_title：Fertility and sterility

authors： Stahl PJ,Masson P,Mielnik A,Marean MB,Schlegel PN,Paduch DA

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:To study the expression and function of adiponectin and its receptors in mouse and human follicle cells and in early embryo development. DESIGN:Whole ovaries, granulosa cells, and cumulus-oocyte complexes isolated from immature mice before and during hormone-induced ovulation were used to analyze the express...

journal_title：Fertility and sterility

authors： Richards JS,Liu Z,Kawai T,Tabata K,Watanabe H,Suresh D,Kuo FT,Pisarska MD,Shimada M

更新日期：2012-08-01 00:00:00

abstract：:Live and dead spermatozoa of human semen were distinguished and evaluated separately with respect to their morphology after supravital staining with buffered eosin. This evaluation was shown to be almost as reliable as that of the commonly stained smear. Different samples from the same individual were found to be simi...

journal_title：Fertility and sterility

authors： Fredricsson B,Waxegård G,Brege S,Lundberg I

更新日期：1977-02-01 00:00:00

abstract：OBJECTIVE:To study the value of virtual hysterosalpingography (VHSG) in the diagnosis of bicornuate vs. septate uterus. DESIGN:Retrospective study of all cases with bicornuate or septate uterus that had VHSG during the last 3 years at our center. SETTING:Private fertility center and radiology institute with universit...

journal_title：Fertility and sterility

authors： Carrascosa P,Sueldo C,Capuñay C,Baronio M,Papier S

更新日期：2011-11-01 00:00:00