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Association of menopause and hormone replacement therapy with large artery remodeling.

Abstract：

OBJECTIVE:To evaluate the remodeling of large arteries according to age at menopause, duration of menopause, and use of hormone therapy (HT). DESIGN:A cross-sectional study consisting of baseline measurements of a multicentric randomized trial were used to evaluate arterial parameters. SETTING:The study was conducted in France, Belgium, and the Netherlands in academic hospitals and private clinics. PATIENT(S):Postmenopausal women (n = 538) with mild hypercholesterolemia. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Common carotid artery intima-media thickness (CCA-IMT), central pulse pressure, and aortic stiffness (carotid-femoral pulse wave velocity) were measured and centrally controlled for quality. Multivariate regression analysis was used to assess the possible covariates associated with arterial parameters. RESULT(S):Women were 58 ± 6 (mean ± SD) years of age with an age of 50 ± 5 at menopause and a mean duration of menopause of 8 ± 7 years. Lower age at menopause, time since menopause, and absence of HT use were independently associated with worsening of the arterial parameters. After multivariate analysis, HT was associated with a lower CCA-IMT (-40 μm [range -64 to -1]), whereas lower age at menopause and menopause duration were respectively associated with a CCA-IMT increase (25 μm/5 y and 27 μm/5 y). Similarly, values of central pulse pressure and pulse wave velocity were lower in HT users (-3.1 mm Hg [-5.1 to -0.9] and -0.31 m/s [-0.63 to -0.02], respectively) but worsened with age at menopause and menopause duration. CONCLUSION(S):The age at menopause, the time since menopause, and the use of HT are independently associated with the thickening and stiffening of the large arteries. CLINICAL TRIAL REGISTRATION NUMBER:NCT00163163.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Gompel A,Boutouyrie P,Joannides R,Christin-Maitre S,Kearny-Schwartz A,Kunz K,Laurent S,Boivin JM,Pannier B,Pornel B,Struijker-Boudier HA,Thuillez C,Van Bortel L,Zannad F,Pithois-Merli I,Jaillon P,Simon T

doi

10.1016/j.fertnstert.2011.09.010

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

1445-50

issue

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(11)02509-X

journal_volume

pub_type

杂志文章,多中心研究,随机对照试验

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Association of menopause and hormone replacement therapy with large artery remodeling.