Azoospermia after treatment with clomiphene citrate in patients with oligospermia.

Abstract:

OBJECTIVE:To describe three cases of azoospermia in patients with oligospermia after clomiphene citrate (CC) intake. DESIGN:Case report. SETTING(S):Academic medical center. PATIENT(S):Three patients with oligospermia. INTERVENTION(S):Three oligospermic men used CC, resulting in azoospermia. MAIN OUTCOME MEASURE(S):Semen analysis after CC use and after discontinuation of CC. RESULT(S):Three patients were sent to our clinic for investigation of their azoospermia after use of CC. They had severe oligozoospermia (sperm concentrations of 3.4, 2.8, and 4.1 x 10(6)/mL, respectively) before treatment with CC. These patients were re-evaluated with two new semen analyses, showing azoospermia. After 3 months without use of the drug, the mean sperm concentration was 2.5 +/- 1.1 x 10(6)/mL. CONCLUSION(S):The benefits of empiric treatment with CC must be balanced with the possible undesirable effects, such as azoospermia.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Pasqualotto FF,Fonseca GP,Pasqualotto EB

doi

10.1016/j.fertnstert.2008.03.036

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

2014.e11-2

issue

5

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(08)00699-7

journal_volume

90

pub_type

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