Azoospermia after treatment with clomiphene citrate in patients with oligospermia.


OBJECTIVE:To describe three cases of azoospermia in patients with oligospermia after clomiphene citrate (CC) intake. DESIGN:Case report. SETTING(S):Academic medical center. PATIENT(S):Three patients with oligospermia. INTERVENTION(S):Three oligospermic men used CC, resulting in azoospermia. MAIN OUTCOME MEASURE(S):Semen analysis after CC use and after discontinuation of CC. RESULT(S):Three patients were sent to our clinic for investigation of their azoospermia after use of CC. They had severe oligozoospermia (sperm concentrations of 3.4, 2.8, and 4.1 x 10(6)/mL, respectively) before treatment with CC. These patients were re-evaluated with two new semen analyses, showing azoospermia. After 3 months without use of the drug, the mean sperm concentration was 2.5 +/- 1.1 x 10(6)/mL. CONCLUSION(S):The benefits of empiric treatment with CC must be balanced with the possible undesirable effects, such as azoospermia.


Fertil Steril


Fertility and sterility


Pasqualotto FF,Fonseca GP,Pasqualotto EB




Has Abstract


2008-11-01 00:00:00














  • Two-dimensional differential in-gel electrophoresis-based proteomics of male gametes in relation to oxidative stress.

    abstract:OBJECTIVE:To identify the relative abundance of proteins in pooled reactive oxygen species (ROS)-positive (ROS+) and ROS-negative (ROS-) semen samples with the use of two-dimensional differential in-gel electrophoresis (2D-DIGE). DESIGN:Spermatozoa suspensions from ROS+ and ROS- groups by 2D-DIGE analysis. SETTING:Te...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hamada A,Sharma R,du Plessis SS,Willard B,Yadav SP,Sabanegh E,Agarwal A

    更新日期:2013-04-01 00:00:00

  • Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review.

    abstract:OBJECTIVE:To report an update on the role of vitamin D (VD) in ovarian physiology with a focus on genes involved in steroidogenesis, follicular development, and ovarian reserve, as well as ovulatory dysfunction associated with polycystic ovary syndrome (PCOS), and ovarian response to assisted reproductive technology (A...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Irani M,Merhi Z

    更新日期:2014-08-01 00:00:00

  • Dysregulation of cytochrome P450c 17 alpha as the cause of polycystic ovarian syndrome.

    abstract::Polycystic ovarian syndrome (PCOS) appears to be due to a previously unrecognized type of steroidogenic abnormality, one in which hyperandrogenism arises from a regulatory abnormality (dysregulation) rather than from enzyme deficiency. It appears that PCOS typically arises from masculinized regulation of the androgen-...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Rosenfield RL,Barnes RB,Cara JF,Lucky AW

    更新日期:1990-05-01 00:00:00

  • Introduction: menopausal hormone therapy: where are we today?

    abstract::In this Views and Reviews section, the authors present the most updated information on menopausal hormone therapy (MHT) and an individualized treatment approach. Care of women through the menopausal transition and post-menopausally requires physicians to integrate multi-organ implications of MHT and understand the ful...

    journal_title:Fertility and sterility



    authors: Cedars MI

    更新日期:2014-04-01 00:00:00

  • Two successful spontaneous pregnancies in a patient with a primary primitive neuroectodermal tumor of the ovary.

    abstract:OBJECTIVE:To describe a patient with primary primitive neuroectodermal tumor of the ovary with two successful spontaneous pregnancies. DESIGN:Case report. SETTING:Tertiary center for gynecologic oncology. PATIENT(S):A 25-year-old woman with two spontaneous pregnancies 5 months after and 2 years after conservative tr...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Demirtas E,Guven S,Guven ES,Baykal C,Ayhan A

    更新日期:2004-03-01 00:00:00

  • Technology requirements for preimplantation genetic diagnosis to improve assisted reproduction outcomes.

    abstract::Preimplantation genetic diagnosis has been proposed as a method to improve assisted reproduction technology outcomes, but different techniques have produced conflicting results. The use of appropriate techniques may provide positive outcomes. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Munné S,Wells D,Cohen J

    更新日期:2010-07-01 00:00:00

  • Effects of low-dose estrogen oral contraceptives on weight, body composition, and fat distribution in young women.

    abstract:OBJECTIVE:To determine prospectively whether the use of low-dose estrogen oral contraceptives (OC) is associated with changes in weight, body composition, or fat distribution. DESIGN:Anthropometric measurements were performed in 49 healthy young (16 to 21 years old) women before commencement of OC use (30 micrograms e...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Reubinoff BE,Grubstein A,Meirow D,Berry E,Schenker JG,Brzezinski A

    更新日期:1995-03-01 00:00:00

  • Prevalence of hysteroscopic findings and histologic diagnoses in patients with abnormal uterine bleeding.

    abstract:OBJECTIVE:To describe the prevalence of hysteroscopic findings and histologic diagnoses in patients with abnormal uterine bleeding (AUB). DESIGN:Retrospective series of consecutive patients. SETTING:Tertiary care university hospital and private office. PATIENT(S):Four thousand fifty-four hysteroscopies with biopsy i...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lasmar RB,Dias R,Barrozo PR,Oliveira MA,Coutinho Eda S,da Rosa DB

    更新日期:2008-06-01 00:00:00

  • Robotically assisted laparoscopic microsurgical tubal reanastomosis: a retrospective study.

    abstract:OBJECTIVE:To evaluate the pregnancy and delivery outcome of robot-assisted tubal reanastomosis. DESIGN:Retrospective cohort study. SETTING:University hospital. PATIENT(S):Ninety-seven patients with available follow-up who underwent the reversal of tubal ligation, with a median age of 37 years (range, 24-47 years). ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Caillet M,Vandromme J,Rozenberg S,Paesmans M,Germay O,Degueldre M

    更新日期:2010-10-01 00:00:00

  • Expression and activation of the membrane-cytoskeleton protein ezrin during the normal endometrial cycle.

    abstract:OBJECTIVE:To examine total ezrin expression (ezrin and phospho-ezrin) through the normal endometrial cycle and to correlate ezrin activation and localization with cytologic changes. DESIGN:Experimental laboratory study. SETTING:University medical centers. PATIENT(S):Reproductive-age women. INTERVENTION(S):A total o...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Tan O,Ornek T,Fadiel A,Carrick KS,Arici A,Doody K,Carr BR,Naftolin F

    更新日期:2012-01-01 00:00:00

  • Hepatitis and reproduction.

    abstract::This bulletin will review the various viral etiologies of hepatitis, their mode of transmission, and implications for infertile couples, pregnant women, and health care workers. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,实务指引,评审


    authors: Practice Committee of the American Society for Reproductive Medicine.

    更新日期:2006-11-01 00:00:00

  • Use of laparoscopically mobilized peritoneum in the creation of a neovagina.

    abstract:OBJECTIVE:To present an alternative technique for the creation of a neovagina. DESIGN:Case study. SETTING:Academic university gynecology clinic. PATIENT(S):A patient diagnosed with müllerian agenesis. INTERVENTION(S):Laparoscopically assisted creation of a neovagina by using peritoneum. MAIN OUTCOME MEASURE(S):Pat...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Templeman CL,Hertweck SP,Levine RL,Reich H

    更新日期:2000-09-01 00:00:00

  • Effect of different procedures of semen preparation on antibody-coated spermatozoa and immunological infertility.

    abstract::To assess whether procedures of semen preparation can reduce the proportion of antibody-coated spermatozoa, semen samples with positive direct mixed antiglobulin reaction (MAR) were washed in media supplemented with 10% or 50% fetal cord serum (FCS). Washing reduced the MAR to a negative level, but the MAR was identic...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hinting A,Vermeulen L,Goethals I,Dhont M,Comhaire F

    更新日期:1989-12-01 00:00:00

  • Alternation of cytosolic carbonic anhydrase isoenzymes during deciduomatal development in pregnant mice.

    abstract:OBJECTIVE:To analyze the activity of cytosolic carbonic anhydrases (CAs) during the pre- and postimplantation stages of pregnancy in mice. Furthermore, to investigate the CA activity in mice in which abortion was induced by injection of substance P. DESIGN:Controlled animal experiment. SETTING:University research lab...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Chiang WL,Liu JY,Liao CY,Yang SF,Hsieh YS,Chu SC

    更新日期:2004-10-01 00:00:00

  • Danazol binding to rat androgen, glucocorticoid, progesterone, and estrogen receptors: correlation with biologic activity.

    abstract::Danazol was found to possess androgenic and glucocorticoid activity in rat bioassays. In contrast, danazol displayed no significant estrogenic activity. In support of these findings, danazol bound to the 8 S androgen receptor of rat prostate cytosol and to the glucocorticoid receptor of rat liver cytosol, but danazol ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Barbieri RL,Lee H,Ryan KJ

    更新日期:1979-02-01 00:00:00

  • Anabolic steroid-induced hypogonadism: diagnosis and treatment.

    abstract:OBJECTIVE:To develop an understanding of hypogonadal men with a history of anabolic-androgenic steroid (AAS) use and to outline recommendations for management. DESIGN:Review of published literature and expert opinions. Intended as a meta-analysis, but no quality studies met the inclusion criteria. SETTING:Not applica...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,meta分析,评审


    authors: Rahnema CD,Lipshultz LI,Crosnoe LE,Kovac JR,Kim ED

    更新日期:2014-05-01 00:00:00

  • Successful treatment of severe endometriosis in two premenopausal women with an aromatase inhibitor.

    abstract:OBJECTIVE:To treat severe endometriosis in premenopausal women with an aromatase inhibitor and to document the efficacy and side effects of this new treatment. DESIGN:Case report. SETTING:Clinical practice setting. PATIENT(S):Patients were premenopausal endometriosis cases confirmed by prior laparoscopy. INTERVENTI...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Shippen ER,West WJ Jr

    更新日期:2004-05-01 00:00:00

  • Inhibition of ovarian luteinizing hormone (LH) and follicle-stimulating hormone receptor levels with an LH-releasing hormone agonist during the estrous cycle in the rat.

    abstract::A single injection of the luteinizing hormone (LH)-releasing hormone (LHRH) agonist [D-Ala6,des-Gly-NH2(10)]LHRH ethylamide to female rats on diestrus I produced a marked reduction in ovarian LH/human chorionic gonadotropin (hCG) and follicle-stimulating hormone (FSH) receptor levels, uterine weight, and plasma proges...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kledzik GS,Cusan L,Auclair C,Kelly PA,Labrie F

    更新日期:1978-09-01 00:00:00

  • The effectiveness of intracytoplasmic sperm injection combined with piezoelectric stimulation in infertile couples with total fertilization failure.

    abstract:OBJECTIVE:To assess the effectiveness of intracytoplasmic sperm injection (ICSI) combined with piezoelectric stimulation in infertile couples with a history of total fertilization failure (TFF). DESIGN:Prospective controlled trial. SETTING:Clinical IVF laboratory. PATIENT(S):Seventy-one couples undergoing ICSI on si...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Baltaci V,Ayvaz OU,Unsal E,Aktaş Y,Baltaci A,Turhan F,Ozcan S,Sönmezer M

    更新日期:2010-08-01 00:00:00

  • A new concept for anastomosis of the fallopian tube: tissue reconstruction with nonpenetrating, arcuate, legged clips in the rat model.

    abstract:OBJECTIVE:To evaluate the titanium Kirsch-Zhu microclip microsurgical reanastomoses of the fallopian tubes. DESIGN:Compare the reanastomoses of the rat uterine horn between Kirsch-Zhu clips (Cushman Engineering, Albuquerque, NM) (group A) and conventional suture microsurgical techniques (group B). SETTING:Microsurger...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Tredway DR,Kirsch WM,Zhu YH,Weber K,Norburg M,Saukel GW,Seraj I

    更新日期:1994-09-01 00:00:00

  • Fertility preservation in women with breast cancer undergoing adjuvant chemotherapy: a systematic review.

    abstract:OBJECTIVE:To investigate methods of fertility preservation in younger women exposed to adjuvant chemotherapy for breast cancer. DESIGN:Systematic review of literature. SETTING:Academic Department of Medical Oncology. PATIENT(S):Premenopausal women exposed to adjuvant chemotherapy for breast cancer. MAIN OUTCOME MEA...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Cruz MR,Prestes JC,Gimenes DL,Fanelli MF

    更新日期:2010-06-01 00:00:00

  • A prospective evaluation of uterine abnormalities by saline infusion sonohysterography in 1,009 women with infertility or abnormal uterine bleeding.

    abstract:OBJECTIVE:To evaluate the role of saline infusion sonohysterography (SIS) in the investigation of uterine abnormalities and malformations in patients referred for infertility work-up compared with women with abnormal uterine bleeding (AUB). DESIGN:Prospective cohort study. SETTING:Academically oriented private practi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Tur-Kaspa I,Gal M,Hartman M,Hartman J,Hartman A

    更新日期:2006-12-01 00:00:00

  • Impact of fatness, insulin, and gynecological age on luteinizing hormone secretory dynamics in adolescent females.

    abstract:OBJECTIVE:To study the link between fatness and gonadotropin secretion. Overweight status is linked to polycystic ovary syndrome (PCOS) in adolescents. We postulated that heavier adolescents without symptoms would secrete LH with: [1] increased pulse frequency (LHPF) and [2] exaggerated integrated concentrations (LHAUC...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kasa-Vubu JZ,Jain V,Welch K

    更新日期:2010-06-01 00:00:00

  • Treatment of functional amenorrhea-galactorrhea with 2-bromoergocryptine.

    abstract::The present study was undertaken to investigate not only the effectiveness of bromoergocryptine therapy in 13 women with amenorrhea-galactorrhea and hyperprolactinemia without evidence of organic pathology, but also to assess the value of pretreatment evaluation in predicting the response to therapy. Sella turcica tom...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Wiebe RH,Hammond CB,Handwerger S

    更新日期:1977-04-01 00:00:00

  • Extrahypothalamic luteinizing hormone-releasing factor (LRF): release of immunoreactive LRF in vitro.

    abstract::The human placenta in vitro releases luteinizing hormone-releasing factor (LRF) which is immunologically indistinguishable from hypothalamic LRF. The release of LRF by placental tissue increased during the 4 days of culture and exceeded the original tissue content more than 5-fold. These data suggest that the human pl...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Siler-Khodr TM,Khodr GS

    更新日期:1979-09-01 00:00:00

  • A randomized, placebo-controlled, double-blind study evaluating leuprolide acetate depot treatment before myomectomy.

    abstract::Eighteen premenopausal women with symptomatic leiomyomata uteri were enrolled in a stratified, randomized, double-blind, placebo-controlled study evaluating the efficacy of leuprolide acetate (LA) depot treatment before myomectomy. Stratification was based on pretreatment uterine volume (less than 600 cm3 versus great...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Friedman AJ,Rein MS,Harrison-Atlas D,Garfield JM,Doubilet PM

    更新日期:1989-11-01 00:00:00

  • Inherited mutation of the luteinizing hormone/choriogonadotropin receptor (LHCGR) in empty follicle syndrome.

    abstract:OBJECTIVE:To test by genomic analysis whether empty follicle syndrome (EFS) in a family with two affected sisters has a genetic basis. DESIGN:Whole-exome sequencing in the context of clinical genetics. SETTING:University hospital. PATIENT(S):Two women (36 and 32 years old at the time of the study) with EFS. INTERVE...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Yariz KO,Walsh T,Uzak A,Spiliopoulos M,Duman D,Onalan G,King MC,Tekin M

    更新日期:2011-08-01 00:00:00

  • Failure of seminal plasma to enter the uterus and oviducts of the rabbit following artificial insemination.

    abstract::Twelve adult does in estrus were artificially inseminated with 1 ml of semen from bucks that had received injections of 3H-thymidine 22 to 32 days previously. The ejaculates contained radioactive seminal plasma and unlabeled sperm. The reproductive tracts of the does were removed at selected intervals after inseminati...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Asch RH,Balmaceda J,Pauerstein CJ

    更新日期:1977-06-01 00:00:00

  • Day 2 embryo transfer (ET) and day 3 ET afford similar reproductive outcomes in the poor responder.

    abstract::A retrospective review of 237 initial, fresh nondonor IVF cycles in which all embryos generated during the cycle were transferred on either day 2 (n = 109) or day 3 (n = 128) were evaluated with regards to reproductive outcomes. Patients who underwent a day 2 ET had similar conception (18% vs. 16%; relative risk [RR],...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Dayal MB,Frankfurter D,Athanasiadis I,Peak D,Dubey A,Gindoff PR

    更新日期:2011-03-01 00:00:00

  • BRCA mutation carriers show normal ovarian response in in vitro fertilization cycles.

    abstract:OBJECTIVE:To evaluate the association between carriage of BRCA1/2 mutations and ovarian performance, as demonstrated by in vitro fertilization (IVF) outcomes. DESIGN:Retrospective cohort study. SETTING:Two tertiary IVF centers. PATIENT(S):BRCA mutation carriers undergoing IVF for preimplantation genetic diagnosis (P...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,多中心研究


    authors: Shapira M,Raanani H,Feldman B,Srebnik N,Dereck-Haim S,Manela D,Brenghausen M,Geva-Lerner L,Friedman E,Levi-Lahad E,Goldberg D,Perri T,Eldar-Geva T,Meirow D

    更新日期:2015-11-01 00:00:00