Interleukin 10: ability to minimize postoperative intraperitoneal adhesion formation in a murine model.

Abstract:

OBJECTIVE:To determine the ability of interleukin 10 (IL-10) to suppress postoperative intraperitoneal adhesion formation. DESIGN:Randomized, controlled trial. SETTING:University animal research facility. ANIMALS:Six-week-old Swiss Webster mice undergoing a standardized intraperitoneal operative procedure. INTERVENTIONS:Animals were randomized to "surgery" or "no surgery" and then further randomized to receive intraperitoneal injections of 1 mL phosphate-buffered saline (PBS) or 1 microgram/kg IL-10 in 1 mL PBS. Vehicle-only doses were given immediately after surgery and then every 24 hours for a total of four injections. Interleukin 10 injections were similarly given but with an added preoperative injection 30 minutes before surgery in one half of the animals. MAIN OUTCOME MEASURE:Adhesion formation. RESULTS:Animals treated with vehicle or IL-10 but not undergoing surgical intervention had no intraperitoneal adhesions. Animals undergoing surgery who were treated with IL-10, with or without a preoperative dose, had significantly lower postoperative adhesion scores than did control animals who postoperatively received PBS only. CONCLUSION:Interleukin-10 is effective at limiting postoperative intraperitoneal adhesion formation with minimal evident systemic side effects.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Montz FJ,Holschneider CH,Bozuk M,Gotlieb WH,Martinez-Maza O

doi

10.1016/s0015-0282(16)56769-7

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

1136-40

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)56769-7

journal_volume

61

pub_type

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