Internal jugular vein thrombosis in patients with ovarian hyperstimulation syndrome.

Abstract:

OBJECTIVE:To describe a case of bilateral internal jugular vein thrombosis complicating ovarian hyperstimulation syndrome (OHSS). DESIGN:Case report. SETTING:Internal medicine ward in a teaching hospital. PATIENT:A 28-year-old nulliparous woman undergoing IVF. INTERVENTION(S):Ultrasonographic Doppler of the neck veins was performed because of pain and swelling in the neck, and bilateral jugular vein thromboses were detected. Laboratory evaluation revealed activated protein C resistance caused by factor V Leiden mutation. Low-molecular-weight heparin (enoxaparin) was administered for the remainder of the pregnancy and for 6 weeks after delivery. MAIN OUTCOME MEASURE:Resolution of jugular venous thromboses documented by ultrasonographic Doppler and normal progression of pregnancy. RESULT(S):The patient delivered healthy twins at term. There were no complications arising from the jugular vein thromboses or the low-molecular-weight heparin treatment. CONCLUSION(S):Unusually located venous thrombosis should prompt an evaluation for a hypercoagulable state. The high prevalence (4%-7%) of factor V Leiden mutation in most Western populations and the mutation's potential contribution to thrombotic complications in OHSS suggest that screening for this abnormality in women undergoing IVF may be indicated.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Ellis MH,Nun IB,Rathaus V,Werner M,Shenkman L

doi

10.1016/s0015-0282(97)00459-7

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

140-2

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015028297004597

journal_volume

69

pub_type

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