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Gonadotropin-releasing hormone antagonist administration enhances gonadotrope responsiveness at doses inadequate to suppress immunoassayable gonadotropin levels.

Abstract：

:Chronic GnRH antagonist therapy produces enhanced gonadotrope responsiveness to supraphysiologic stimuli despite the lack of any measurable suppression of gonadotropin levels. This indicates that GnRH antagonists fundamentally alter gonadotrope response mechanisms without inhibiting gonadotropin release. Beyond the physiologic implications, these data may eventually impact the development of clinical protocols. Benefits could include enhancements in the endogenous gonadotropin flare during controlled ovarian hyperstimulation cycles. Additionally, proposed contraceptive protocols where GnRH antagonists are used to produce the initial inhibition in gonadotropin release and are then followed by a GnRH-a (to avoid the gonadotropin flare) may in fact produce paradoxical results.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Scott RT Jr,Illions EH,Carey KD,Navot D

subject

Has Abstract

pub_date

1994-11-01 00:00:00

pages

1069-71

issue

5

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)57076-9

journal_volume

62

pub_type

杂志文章

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