Successful induction of ovulation with synthetic luteinizing hormone-releasing hormone in anovulatoy infertility.

Abstract:

:13 women with suspected hypothalamic anovulation were treated with l uteinizing hormone-releasing hormone (LH-RH) by a variety of regimens. 3 women received LH-RH by continuous intravenous infusion equal to 100 mcg LH-RH for 8 hours, followed by an acute injection of LH-RH 100 mcg. 10 days later the infusion was repeated without the supplemental injecti on and coitus advised immediately after the end of the 2nd infusion. 10 patients were given LH-RH by injection of 50 mch/day for 10 days. Coitus was indicated every other day from Day 8 of therapy. Presumptive ovulation was determined on each mode of therapy. 2 of the 3 intravenous patients had presumptive ovulation responses wihtout conception. 4 of the 10 injection patients had presumptive ovulation signs and 2 conceived. The 6 remaining injection patients responded with increased estrogens and estrogenic effect on cervical mucus. The results confirm the therapeutic role of LH-RH in certain cases of sterility.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Zárate A,Canales ES,Schally AV,Ayala-Valdés L,Kastin AJ

doi

10.1016/s0015-0282(16)39196-8

subject

Has Abstract

pub_date

1972-09-01 00:00:00

pages

672-4

issue

9

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)39196-8

journal_volume

23

pub_type

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