Abstract：
OBJECTIVE:To determine the role of heterozygosity for mutations in the 21-hydroxylase gene (CYP21) in the pathogenesis of hyperandrogenism. DESIGN:Controlled clinical study. SETTING:Tertiary care institutional hospital. PATIENT(S):Forty hirsute women and 13 healthy control women. INTERVENTION(S):The source of androgen excess was determined by the changes in serum testosterone levels in response to a single 3.75-mg i.m. dose of triptorelin. MAIN OUTCOME MEASURE(S):CYP21 molecular genetic analysis and serum 17-hydroxyprogesterone levels. RESULT(S):Eight patients and one control were heterozygous carriers of CYP21 mutations. Two patients with adrenal hyperandrogenism and one patient with ovarian hyperandrogenism, who carried the V281L mutation had an increased ACTH-stimulated 17-hydroxyprogesterone level (>4.1 ng/mL) that persisted during gonadal suppression. Another patient with adrenal hyperandrogenism carried the V281L mutation, and her ACTH-stimulated 17-hydroxyprogesterone level was elevated only during gonadal suppression. Four patients (three with idiopathic hirsutism, one with ovarian hyperandrogenism) and one control were carriers of CYP21 mutations typically associated with classic congenital adrenal hyperplasia but had normal basal and ACTH-stimulated 17-hydroxyprogesterone levels. Nine patients without CYP21 mutations had increased ACTH-stimulated 17-hydroxyprogesterone levels; these decreased to normal in six of the patients during gonadal suppression. CONCLUSION(S):The response of serum 17-hydroxyprogesterone to ACTH does not predict CYP21 carrier status. No clear concordance was found between the CYP21 genotype and the functional origin of androgen excess.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Escobar-Morreale HF,San Millán JL,Smith RR,Sancho J,Witchel SFdoi
10.1016/s0015-0282(99)00317-9keywords:
subject
Has Abstractpub_date
1999-10-01 00:00:00pages
629-38issue
4eissn
0015-0282issn
1556-5653pii
S0015-0282(99)00317-9journal_volume
72pub_type
临床试验,杂志文章abstract：OBJECTIVE:To use microarray analysis as an unbiased approach to identify genes involved in the induction and growth of uterine leiomyomata. DESIGN:Screen by arrays for up to 12,000 genes in leiomyoma (L) and control myometrium (M) from nine patients. SETTING:University research laboratories. PATIENT(S):Nine patients...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(02)03191-6
更新日期：2002-07-01 00:00:00
abstract：OBJECTIVE:To test the hypothesis that oligo-ovulatory ovulation is associated with hyperandrogenemia in the absence of other clinical signs of androgen excess. DESIGN:Retrospective cohort controlled. SETTING:Tertiary care university-based outpatient clinic. PATIENT(S):Thirty-two consecutive nonhirsute oligo-ovulator...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)80089-1
更新日期：1997-03-01 00:00:00
abstract：:Sperm penetration through bovine cervical mucus was determined and correlated with the sperm characteristics in three fractions of the split ejaculate and in the whole ejaculate from 40 men of infertile couples in which a female cause of infertility had been ruled out. Sperm concentration and motility were found to be...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1984-08-01 00:00:00
abstract：:After initial videolaseroscopy for the treatment of endometriosis-associated infertility, 157 patients underwent a second-look laparoscopy to evaluate and treat recurrence of disease and/or adhesions. The patients were divided into two groups. Group 1 consisted of 135 patients who underwent second-look laparoscopy for...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)53576-6
更新日期：1990-06-01 00:00:00
abstract：OBJECTIVE:To investigate whether abnormalities in serum concentrations of 1,25-dihydroxyvitamin D [1,25(OH)(2)D], 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), calcium, and phosphorus were associated with risk of polycystic ovary syndrome (PCOS) and obesity. The possible correlations of the calciotropic hor...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.11.031
更新日期：2010-03-01 00:00:00
abstract：:Certainly, varicoceles can have a substantive effect on sperm production in infertile males. In addition, varicocele repair may optimize sperm production. However, additional studies and evaluation of the role of varicocele repair in men with this condition (nonobstructive azoospermia) are warranted. ...
journal_title：Fertility and sterility
pub_type： 评论,杂志文章
doi：10.1016/j.fertnstert.2010.11.057
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:The growth of the follicles induced by gonadotropins during IVF treatment is accompanied by physiologic angiogenesis, which is essential for the maturation of the oocytes. We describe the IVF-induced changes in the vascularization and compare normal with polycystic ovaries (PCOs). DESIGN:Prospective study. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.04.048
更新日期：2004-11-01 00:00:00
abstract：OBJECTIVE:To evaluate the efficacy of a dry versus humidified incubator on human embryo development ex vivo. DESIGN:Prospective, double-blind, randomized, controlled trial. SETTING:Private fertility centers. PATIENT(S):A total of 297 women undergoing in vitro fertilization randomized into two groups. INTERVENTION(S...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.fertnstert.2017.05.036
更新日期：2017-08-01 00:00:00
abstract：:In a prospective study, 140 patients with infertility because of ovulatory factors (group A) were followed up for 6 months after failure to achieve pregnancy using human menopausal gonadotropin (hMG) therapy. They included cases of oligomenorrhea, polycystic ovarian disease (PCOD), and hypogonadotropic amenorrhea. The...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(16)54237-x
更新日期：1991-04-01 00:00:00
abstract：OBJECTIVE:To compare the effects of serum with those of Albuminar-5 (Armour Pharmaceutical Co., Eastbourne, Sussex, United Kingdom) as medium supplements to Earl's balanced salt solution (EBSS) for IVF and subsequent embryo development. DESIGN:A retrospective study. Gametes and embryos from 318 patients were cultured ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)57978-3
更新日期：1995-12-01 00:00:00
abstract：OBJECTIVE:To investigate the expression and localization of interleukin-8 (IL-8) and monocyte chemotactic protein 1 (MCP-1) in women with and without endometriosis. DESIGN:Comparative immunohistochemical study. SETTING:Academic medical center. PATIENT(S):Ectopic (n = 24) and homologous eutopic endometrium (n = 24) f...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.12.067
更新日期：2009-03-01 00:00:00
abstract：OBJECTIVE:To compare conventional IVF with ICSI in the subfertile male population using sibling oocytes. Results from males with isolated severe teratozoospermia also are analyzed. DESIGN:Prospective experimental study. SETTING:University based IVF clinic. PATIENT(S):Group A: 18 patients with one or more abnormaliti...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(98)00538-x
更新日期：1999-04-01 00:00:00
abstract：:Many studies evaluating a possible relationship between inherited thrombophilia and the etiology of unexplained infertility have been performed recently. No significant difference in the prevalence of three genetic mutations associated with the increased risk of thrombophilia (Factor V Leiden G1691A, prothrombin G2021...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.10.014
更新日期：2010-07-01 00:00:00
abstract：:Adult beagle bitches received 0.2 to 75 mg/kg doses of medroxyprogesterone acetate (MPA) once every 3 months for 1 to 1.5 years. Doses greater than 2.0 mg/kg prevented the recurrence of ovarian cycles; lower doses did not. MPA (10 and 75 mg/kg) induced a dose-related development of multiple, large (greater than 5 mm d...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1981-09-01 00:00:00
abstract：OBJECTIVE:To examine the prevalence of migraine in women with chronic pelvic pain with and without endometriosis. DESIGN:Prospective study of headache, pelvic pain, and quality of life before laparoscopic surgery for pelvic pain. Endometriosis was diagnosed pathologically. Headaches were classified as migraine or non-...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.11.037
更新日期：2011-03-01 00:00:00
abstract：:A new direct-to-consumer genetic test purports to detect fetal gender as early as five weeks of pregnancy. The availability of this test highlights the consequences of the current system of oversight for genetic tests and underscores the need for an enhanced regulatory framework to ensure the accuracy, reliability, an...
journal_title：Fertility and sterility
pub_type： 社论
doi：10.1016/j.fertnstert.2006.03.016
更新日期：2006-07-01 00:00:00
abstract：:A patient with Nelson's syndrome whose pregnancy was complicated by symptomatic enlargement of an ACTH-producing pituitary tumor was described. Emergency ablative surgery was performed with successful outcomes for both mother and infant. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)48932-6
更新日期：1985-10-01 00:00:00
abstract：OBJECTIVE:To characterize sperm parameters from thawed semen samples of men with different cancers who cryopreserved semen before oncologic therapy. DESIGN:Retrospective cohort study. SETTING:Tertiary academic medical center. PATIENT(S):1,010 semen samples collected between 1994 to 2010. INTERVENTION(S):None. MAIN...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2012.09.031
更新日期：2013-02-01 00:00:00
abstract：OBJECTIVE:To study the association between two single-nucleotide polymorphisms (SNPs) variants (rs2241766 and rs1501299) of the adiponectin gene (ADIPOQ) and polycystic ovary syndrome (PCOS) in PCOS family trios. DESIGN:Family-based study. SETTING:University hospital. PATIENT(S):A total of 224 unrelated PCOS proband...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2014.01.035
更新日期：2014-05-01 00:00:00
abstract：OBJECTIVE:To investigate the association of AMH and AMHRII polymorphisms with reproductive abilities in a sample of women with idiopathic infertility. DESIGN:Case-control study. SETTING:University Department of Obstetrics and Gynecology, and University Unit of Clinical Genetics. PATIENT(S):76 women with idiopathic s...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.05.025
更新日期：2010-09-01 00:00:00
abstract：OBJECTIVE:To determine whether serum interleukin (IL)-8 concentration can be measured in patients with ovarian endometrioma and whether this measurement is a useful tool in diagnosing this disease. DESIGN:A controlled clinical study and an in vitro study. SETTING:Department of Obstetrics and Gynecology, Tottori Unive...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.07.1355
更新日期：2008-10-01 00:00:00
abstract：:The complete lack of information about mast cells as a source of histamine and potential target cells for histamine in human testes prompted us to investigate these issues in testes of fertile and infertile patients using a combination of laser microdissection, reverse transcription-polymerase chain reaction (RT-PCR),...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.12.002
更新日期：2005-04-01 00:00:00
abstract：OBJECTIVE:To enable serodiscordant couples to reproduce while minimizing the risk of infecting the female partner and to demonstrate the feasibility of including these couples in an insemination program. DESIGN:Prospective follow-up study. SETTING:Ambulatory IUIs. PATIENT(S):Fifty-six HIV-1-serodiscordant couples wi...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/j.fertnstert.2004.02.128
更新日期：2004-10-01 00:00:00
abstract：OBJECTIVE:To study the safety and efficacy of ovarian stimulation and oocyte cryopreservation as a method of fertility preservation in women with Turner syndrome (TS). DESIGN:Retrospective cohort study. SETTING:Reproductive medicine clinic. PATIENT(S):Seven women with TS who attended the clinic between 2011 and 2017...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2018.11.010
更新日期：2019-03-01 00:00:00
abstract：:Plasminogen activator activity in PF was assayed by the fibrinolysis method described by Strickland and Beers. In 45 patients studied, there were no discernible differences according to whether patients had endometriosis and/or pelvic adhesive disease. No differences were detected according to when in the menstrual cy...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)48752-2
更新日期：1985-08-01 00:00:00
abstract：:The influence of high-dose anabolic steroid administration on endocrine and semen parameters of 41 bodybuilders (age, 26.7 +/- 0.7 years [mean +/- SEM]; height, 182 +/- 1 cm; weight, 97.5 +/- 2.0 kg) was investigated. History of anabolic steroid administration was recorded retrospectively, and results of semen analysi...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)53172-0
更新日期：1989-12-01 00:00:00
abstract：OBJECTIVE:The objective of the present studies was to determine whether luteinizing hormone (LH) depletes ascorbic acid in the preovulatory follicle. DESIGN:Controlled, prospective experimental study. SETTING:University-based research center. ANIMAL(S):Sprague-Dawley female rats. INTERVENTION(S):Follicular growth a...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(00)01550-8
更新日期：2000-11-01 00:00:00
abstract：OBJECTIVE:To determine the influence of estrogens on male fertility. DESIGN:A 36-year-old eugonadal male was subjected to two different regimens of treatment with ethinyl estradiol (EE2). Sperm quality, immunoreactive luteinizing hormone (LH) and follicle-stimulating Hormone (FSH), testosterone (T), estrone (E1), estr...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)55271-6
更新日期：1992-09-01 00:00:00
abstract：OBJECTIVE:To describe and evaluate the surgical treatment of large ovarian endometriomas by an extraovarian endosurgical technique. DESIGN:Prospective case series study. SETTING:University center and tertiary referral center for endoscopic surgery. PATIENTS:Patients with large ovarian endometriomas. INTERVENTION:A ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)58561-6
更新日期：1996-10-01 00:00:00
abstract：:Because spermatocyte meiotic error results in embryonic sex chromosomal aneuploidy, it is speculated that teratospermia correlates with increased embryonic sex chromosomal abnormalities. Our findings contradict this theory, suggesting that morphology does not correlate with sex chromosomal genotype. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.07.1006
更新日期：2010-02-01 00:00:00
