Fertility preservation in women with breast cancer undergoing adjuvant chemotherapy: a systematic review.

Abstract:

OBJECTIVE:To investigate methods of fertility preservation in younger women exposed to adjuvant chemotherapy for breast cancer. DESIGN:Systematic review of literature. SETTING:Academic Department of Medical Oncology. PATIENT(S):Premenopausal women exposed to adjuvant chemotherapy for breast cancer. MAIN OUTCOME MEASURE(S):Fertility preservation. RESULT(S):Data for fertility preservation in this setting come from nonrandomized trials and observational studies. The main methods of fertility preservation are ovarian protection by gonadotropin-releasing hormone (GnRH) agonists, cryopreservation of embryos after in vitro fertilization, and preservation of operatively sampled ovarian tissue or eggs after stimulation and puncture. Ongoing trials are assessing the role of ovarian protection by GnRH agonists. CONCLUSION(S):At present, there are no high-level, evidence-based recommendations for preservation of fertility or of ovarian function in women with breast cancer. This is an important issue for young breast cancer survivors, and further studies are needed. Moreover, the interplay between ovarian protection by GnRH agonists and the efficacy of adjuvant chemotherapy remains elusive.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Cruz MR,Prestes JC,Gimenes DL,Fanelli MF

doi

10.1016/j.fertnstert.2009.02.055

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

138-43

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(09)00474-9

journal_volume

94

pub_type

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