Importance of the biopsy date in autologous endometrial cocultures for patients with multiple implantation failures.


OBJECTIVE:To analyze the effectiveness of autologous endometrial coculture by the cycle day of the endometrial biopsy. DESIGN:Retrospective study. SETTING:University-based IVF center. PATIENT(S):Two hundred eight patients with multiple IVF failures. INTERVENTION(S):Embryos were split and randomly allocated to growth on autologous endometrial coculture or conventional media. MAIN OUTCOME MEASURE(S):Embryo quality and pregnancy outcome. RESULT(S):The overall clinical pregnancy rate was 41.8%. Embryos grown on autologous endometrial coculture were of higher quality (more blastomeres and less fragmentation) than embryos grown with conventional media. Early luteal biopsies (<5 days after LH surge) for autologous endometrial coculture did not demonstrate an improvement in embryo quality as compared to the significant improvement demonstrated with later luteal endometrial biopsies (> or =5 days after LH surge). The date of the biopsy was predictive of pregnancy outcome when using autologous endometrial coculture (44.7% [> or =5 days after LH surge] vs. 18.8% [<5 days after LH surge], P=.012). CONCLUSION(S):We have demonstrated an improvement in embryo quality when using autologous endometrial coculture. The improvement in embryo quality and higher pregnancy rates were limited to biopsies > or =5 days after the LH surge. This suggests that mid/late luteal phase endometrium contains factors that enhanced embryo growth and subsequent implantation.


Fertil Steril


Fertility and sterility


Spandorfer SD,Barmat LI,Navarro J,Liu HC,Veeck L,Rosenwaks Z





Has Abstract


2002-06-01 00:00:00














  • Effects of testosterone and dihydrotestosterone on spermatogenesis, rete testis fluid, and peripheral androgen levels in hypophysectomized rats.

    abstract::To compare the effects of testosterone (T) and dihydrotestosterone (DHT) on the maintenance and the restoration of spermatogenesis, hypophysectomized (APX) rats were treated daily for 35 days with 0.5 mg of T propionate (TP) or DHT propionate (DHTP) beginning 5 or 33 days after hypophysectomy. In the maintenance exper...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Harris ME,Bartke A,Weisz J,Watson D

    更新日期:1977-10-01 00:00:00

  • Early ovarian hyperstimulation syndrome is completely prevented by gonadotropin releasing-hormone agonist triggering in high-risk oocyte donor cycles: a prospective, luteal-phase follow-up study.

    abstract::In this prospective, follow-up study of 102 high-risk oocyte donors in their luteal phase, we found a complete absence of ovarian hyperstimulation syndrome (no signs of hemoconcentration or ascites) after the donors were triggered with a gonadotropin releasing-hormone (GnRH) agonist. Due to its powerful preventive eff...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Bodri D,Guillén JJ,Trullenque M,Schwenn K,Esteve C,Coll O

    更新日期:2010-05-01 00:00:00

  • Spontaneous fertility and in vitro fertilization outcome: new evidence of human papillomavirus sperm infection.

    abstract:OBJECTIVE:To evaluate the reproductive outcome of infertile couples undergoing assisted reproduction techniques (ART) with or without human papillomavirus (HPV) semen infection. DESIGN:Cross-sectional clinical study. SETTING:Units of andrology, reproductive medicine, and gynecology. PATIENT(S):A total of 226 inferti...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Garolla A,Engl B,Pizzol D,Ghezzi M,Bertoldo A,Bottacin A,Noventa M,Foresta C

    更新日期:2016-01-01 00:00:00

  • Ovulation induction with pulsatile gonadotropin-releasing hormone administration in patients with polycystic ovarian syndrome.

    abstract::Gonadotropin-releasing hormone (0.025 microgram/kg) was administered intravenously in a pulsatile fashion to four subjects with polycystic ovary syndrome for a total of six cycles. Five of the six cycles culminated in ovulation, although in one course the response occurred too early to be attributed to the therapy alo...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ory SJ,London SN,Tyrey L,Hammond CB

    更新日期:1985-01-01 00:00:00

  • The role of mycoplasmas in reproduction.

    abstract::A study of the incidence of genital tract mycoplasmas in couples attending an infertility clinic and in a group of pregnant women showed that the frequency of isolation was significantly higher in the infertile group (P less than 0.001). In pregnancy, if mycoplasmas were isolated at the first prenatal visit, these org...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Upadhyaya M,Hibbard BM,Walker SM

    更新日期:1983-06-01 00:00:00

  • Measurement of serosal temperatures and depth of thermal injury generated by thermal balloon endometrial ablation in ex vivo and in vivo models.

    abstract:OBJECTIVE:To evaluate the safety profile of endometrial ablation performed with a thermal balloon as defined by serosal temperature elevation and depth of injury. DESIGN:Observational study with histopathologic correlation conducted in ex vivo and in vivo phases. SETTING:Academic medical center. PATIENT(S):Twenty pa...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Shah AA,Stabinsky SA,Klusak T,Bradley KR,Steege JF,Grainger DA

    更新日期:1998-10-01 00:00:00

  • Weight loss by bariatric surgery and subsequent fertility.

    abstract::The purpose of this article is to appraise the literature to ascertain whether the use of bariatric surgery should have a role in the contemporary management of the morbidly obese infertile patient before proceeding with infertility treatment. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,meta分析,评审


    authors: Merhi ZO

    更新日期:2007-02-01 00:00:00

  • Protocols for tracking and witnessing samples and patients in assisted reproductive technology.

    abstract::In view of the increasing emphasis being placed on patient safety and quality health care, it is extremely important to develop fail-safe mechanisms to prevent assisted reproductive technology (ART) mix-ups. Sample mismatch is the most undesirable event that can occur in an IVF laboratory as it may have catastrophic c...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: de los Santos MJ,Ruiz A

    更新日期:2013-12-01 00:00:00

  • Luteal phase defects and ectopic pregnancy.

    abstract:OBJECTIVE:To determine whether luteal phase defect (LPD) may be an etiologic factor in ectopic pregnancy (EP). DESIGN:All patients who were seen over a 6-year period with the chief complaint of infertility underwent an extensive infertility workup and were followed prospectively. The diagnoses of the causes of inferti...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Guillaume AJ,Benjamin F,Sicuranza B,Deutsch S,Spitzer M

    更新日期:1995-01-01 00:00:00

  • Pregnancies and deliveries after transfer of human blastocysts derived from in vitro matured oocytes in in vitro maturation cycles.

    abstract::A total of 82 patients underwent 106 cycles in which immature oocytes were recovered after hCG priming and transferred at blastocyst-stage. After transfer, the implantation rate was 26.8%, and the clinical pregnancy rate was 51.9%. We found that the oocytes retrieved after hCG priming in women with high risk of ovaria...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Son WY,Lee SY,Yoon SH,Lim JH

    更新日期:2007-06-01 00:00:00

  • Aberrant expression of glutathione peroxidase in eutopic and ectopic endometrium in endometriosis and adenomyosis.

    abstract:OBJECTIVE:To determine the expression of glutathione peroxidase (GPx) in the eutopic and ectopic endometria during the menstrual cycle in endometriosis and adenomyosis. DESIGN:Immunohistochemical identification of GPx in endometrial tissues identified using the polyclonal antibody. SETTING:Department of obstetrics an...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ota H,Igarashi S,Kato N,Tanaka T

    更新日期:2000-08-01 00:00:00

  • Serum pituitary and steroid hormone levels in the adult male: one value is as good as the mean of three.

    abstract::The result of the hormone concentration of one blood sample was used to determine the accuracy of predicting not only the hormone concentrations of a second and third sample drawn 15 minutes apart, but also the mean value of the three samples. Three blood specimens from 73 men involved in two previously reported studi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Bain J,Langevin R,D'Costa M,Sanders RM,Hucker S

    更新日期:1988-01-01 00:00:00

  • Noncompliance among a group of women using a novel method of contraception.

    abstract:OBJECTIVE:To compare the incidence of noncompliance measured objectively by a home use fertility monitor with the traditional self-reported incidence of compliance in a study of a new method of contraception. DESIGN:Prospective cohort study. SETTING:A large family planning clinic in Edinburgh. PATIENT(S):Thirty-two ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hapangama DK,Glasier AF,Baird DT

    更新日期:2001-12-01 00:00:00

  • Reconstruction of the ovary containing large endometriomas by an extraovarian endosurgical technique.

    abstract:OBJECTIVE:To describe and evaluate the surgical treatment of large ovarian endometriomas by an extraovarian endosurgical technique. DESIGN:Prospective case series study. SETTING:University center and tertiary referral center for endoscopic surgery. PATIENTS:Patients with large ovarian endometriomas. INTERVENTION:A ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Brosens IA,Van Ballaer P,Puttemans P,Deprest J

    更新日期:1996-10-01 00:00:00

  • The effect of increased cardiac output on luteal phase gonadal steroids: a hypothesis for runners amenorrhea.

    abstract::The beta-adrenergic agonist isoproterenol was infused intravenously for 4 hours during the midluteal phase of the cycle in six normal women. A rapid increase in cardiac output occurred for the entire duration of the isoproterenol infusion and serum estrogen and progesterone levels (but not luteinizing hormone levels) ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Casper RF,Wilkinson D,Cotterell MA

    更新日期:1984-03-01 00:00:00

  • Evaluation of human papilloma virus in semen as a risk factor for low sperm quality and poor in vitro fertilization outcomes: a systematic review and meta-analysis.

    abstract:OBJECTIVE:To analyze the effect of human papilloma virus (HPV) sperm infection on sperm parameters and in vitro fertilization (IVF) outcomes. DESIGN:Systematic review and meta-analysis. SETTING:Not applicable. PATIENTS:Men with HPV sperm infection and couples undergoing IVF. INTERVENTIONS:Searches were conducted in...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Weinberg M,Sar-Shalom Nahshon C,Feferkorn I,Bornstein J

    更新日期:2020-05-01 00:00:00

  • Ovarian preservation in a young patient with Gorlin syndrome and multiple bilateral ovarian masses.

    abstract:OBJECTIVE:To report a case of bilateral ovarian fibromas and ovarian leiomyomas in a young patient with Gorlin syndrome and to highlight issues of fertility preservation, ovarian conservation, and preimplantation genetic diagnosis in this population. DESIGN:Case report. SETTING:University hospital. PATIENT(S):A 15-y...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Morse CB,McLaren JF,Roy D,Siegelman ES,Livolsi VA,Gracia CR

    更新日期:2011-07-01 00:00:00

  • Role of environmental estrogens in the deterioration of male factor fertility.

    abstract:OBJECTIVE:To evaluate the role of the environmental estrogens polychlorinated biphenyls (PCBs) and phthalate esters (PEs) as potential environmental hazards in the deterioration of semen parameters in infertile men without an obvious etiology. DESIGN:Randomized controlled study. SETTING:Tertiary care referral inferti...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rozati R,Reddy PP,Reddanna P,Mujtaba R

    更新日期:2002-12-01 00:00:00

  • Relationship of the individual uterine size and the endometrial thickness in stimulated cycles.

    abstract::At present there is no agreement regarding the usefulness of monitoring the endometrial thickness in stimulated cycles. We tested prospectively the hypothesis of a linear relationship of the given individual uterine size and the endometrial thickness in stimulated cycles using a 240 degrees transvaginal sector scanner...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Strohmer H,Obruca A,Radner KM,Feichtinger W

    更新日期:1994-05-01 00:00:00

  • Deoxyribonucleic acid repair and apoptosis in testicular germ cells of aging fertile men: the role of the poly(adenosine diphosphate-ribosyl)ation pathway.

    abstract:OBJECTIVE:To explore the relationship between men's age and DNA damage repair proteins related to apoptosis in human testicular germ cells. DESIGN:Retrospective case-control study. SETTING:Academic institutions. PATIENT(S):Testicular specimens were obtained from 22 fertile volunteers aged 20-82 years. INTERVENTION(...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: El-Domyati MM,Al-Din AB,Barakat MT,El-Fakahany HM,Xu J,Sakkas D

    更新日期:2009-05-01 00:00:00

  • Who's keeping count? The need for regulation is a relative matter.

    abstract::It is important to have an accurate model for calculating limits to sperm donation so as to avoid inadvertent half-sibling mating and help protect the rights and welfare of the donor- inseminated child. The most highly developed model to date cannot be used as there is inadequate regulation of donor insemination among...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Sawyer N

    更新日期:2009-12-01 00:00:00

  • Endometrial integrin expression in women with recurrent implantation failure after in vitro fertilization and its relationship to pregnancy outcome.

    abstract:OBJECTIVE:To determine expression of integrins α₁, α₄, and αVβ₃ in the glandular and luminal epithelium, stroma, and cells in the blood vessel walls of the endometrium from women with recurrent implantation failure (RIF) and to determine if they are of prognostic value in determining pregnancy outcome. DESIGN:Prospect...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Coughlan C,Sinagra M,Ledger W,Li TC,Laird S

    更新日期:2013-09-01 00:00:00

  • Short-term weight change and live birth among women with unexplained infertility and polycystic ovary syndrome undergoing ovulation induction.

    abstract:OBJECTIVE:To determine if short-term weight change among women with unexplained infertility (UI) and polycystic ovary syndrome (PCOS) undergoing ovulation induction is associated with live birth. DESIGN:Secondary analysis of randomized trials. SETTING:Multicenter fertility trial sites. PATIENT(S):A total of 900 wome...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Vitek W,Sun F,Hoeger KM,Santoro N,Diamond MP,Zhang H,Legro RS,Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network.

    更新日期:2020-11-01 00:00:00

  • Differences in seminal parameters in specimens collected via intercourse and incomplete intercourse (coitus interruptus)

    abstract::Whatever the mechanism of such improvements may be, the results in this study point out that coitus interruptus in the human may not be the method of choice for collection of semen specimens, especially in patients with spermatogenic dysfunctions such as hypospermia, oligospermia, and asthenospermia. It should also be...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Zavos PM,Kofinas GD,Sofikitis NV,Zarmakoupis PN,Miyagawa I

    更新日期:1994-06-01 00:00:00

  • Treatment of pelvic pain associated with endometriosis: a committee opinion.

    abstract::Pain associated with endometriosis may involve many mechanisms and requires careful evaluation to confirm the diagnosis and exclude other potential causes. Both medical and surgical treatments for pain related to endometriosis are effective, and choice of treatment must be individualized. This document replaces the do...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Practice Committee of the American Society for Reproductive Medicine.

    更新日期:2014-04-01 00:00:00

  • Neuroendocrine response to an intravenous L-tryptophan challenge in women with premenstrual syndrome.

    abstract:OBJECTIVE:To evaluate the neuroendocrine responses to an intravenous L-tryptophan challenge across the menstrual cycle in women with premenstrual syndrome (PMS) and controls. DESIGN:Controlled clinical study. SETTING:The Clinical Research Center of an academic research environment. PATIENT(S):Women with PMS and heal...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Rasgon N,McGuire M,Tanavoli S,Fairbanks L,Rapkin A

    更新日期:2000-01-01 00:00:00

  • The endometrial biopsy for diagnosis of luteal phase deficiency.

    abstract::We studied endometrial luteal phase in specimens from 660 biopsies done in 300 patients from our infertility clinic. A minimum of two (240 women) or three (60 women) endometrial biopsy specimens from separate cycles were taken regardless of the previous histologic findings in all patients. Statistical analysis of resu...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Balasch J,Vanrell JA,Creus M,Márquez M,González-Merlo J

    更新日期:1985-11-01 00:00:00

  • Peritoneal fluid and serum steroids in infertility patients.

    abstract::Peritoneal fluid and serum were collected from 78 patients at the time of laparoscopy. Twenty-two were fertile controls (CTL), and 56 were infertility patients, who were subdivided into three main groups: endometriosis (EMS), pelvic adhesions (ADH), and ovarian dysfunction (OvDF). Based on control group data, biochemi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lesorgen PR,Wu CH,Green PJ,Gocial B,Lerner LJ

    更新日期:1984-08-01 00:00:00

  • The role of potassium ion and extracellular alkalization in reinitiation of human spermatozoa preserved in electrolyte-free solution at 4 degrees C.

    abstract:OBJECTIVE:To elucidate reinitiation factors in human spermatozoa preserved in the electrolyte-free solution at 4 degrees C. SETTING:Andrology laboratory of our hospital. PATIENTS:Semen samples were obtained from patients attending our infertility clinic. INTERVENTIONS:Ejaculated sperm were centrifuged and washed usi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Saito K,Kinoshita Y,Kanno H,Iwasaki A

    更新日期:1996-06-01 00:00:00

  • Slow excretion of exogenous human chorionic gonadotropin simulating repeated pregnancies and pregnancy losses.

    abstract::We report a patient undergoing hMG-induced superovulation who demonstrated delayed excretion of hCG, originally believed to be because of successive biochemical pregnancies. However, sequential hCG titers after administration of exogenous hCG demonstrated a longer than normal half-life for the excretion of hCG in this...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Maier DB,Metzger DA

    更新日期:1991-10-01 00:00:00