Effect of paramethasone acetate on women with secondary amenorrhea: a preliminary report.

Abstract:

:Twelve women of normal weight (ages 17 to 36 years) with scanty menstrual bleeding were studied. They had no signs of virilization, gynecologic or endocrine pathology, or past history of hormonal treatment. Five women (group 1) experienced withdrawal bleeding after a 3-day course of chlormadinone acetate (2 mg/day) and the other seven did not (group 2). Daily venous blood samples were obtained 10 to 15 days afterward for 5 consecutive days of no treatment (control period) and during the next 5 days while the women received paramethasone acetate (PA), 2 mg/day (treatment period). In each plasma sample the concentrations of 17beta-estradiol (E2) and luteinizing hormone (LH; LER-907) were determined. The mean plasma E2 levels in group 1 were 35 +/- 8 and 86 +/- 10 pg/ml during the control and treatment periods, respectively (P less than 0.001), and the mean plasma LH levels were 28 +/- 6 and 94 +/- 34 ng/ml, respectively (P less than 0.001). No significant changes in plasma E2 and LH levels were observed in group 2 in either period. During the control period, the plasma E2 level in group 2 (14 +/- 2 pg/ml) was lower than that in group 1 (P less than 0.01); however, plasma LH levels were similar in both groups. The administration of PA for 5 months induced monthly ovulation in group 1 but not in group 2. These data suggest that the best results are obtained in women with optimal pretreatment levels of plasma E2.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Cortés-Gallegos V,Alonso-Uriarte ME,Said LE,Cervantes C,Parra A

doi

10.1016/s0015-0282(16)43213-9

subject

Has Abstract

pub_date

1978-04-01 00:00:00

pages

402-6

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)43213-9

journal_volume

29

pub_type

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    更新日期:1989-02-01 00:00:00

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    authors: Eggert-Kruse W,Schwalbach B,Rohr G,Klinga K,Tilgen W,Runnebaum B

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    authors: Kuang Y,Chen Q,Fu Y,Wang Y,Hong Q,Lyu Q,Ai A,Shoham Z

    更新日期:2015-07-01 00:00:00

  • Using sperm posthumously: national guidelines versus practice.

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    doi:10.1016/j.fertnstert.2009.10.035

    authors: Raziel A,Friedler S,Strassburger D,Kaufman S,Umansky A,Ron-El R

    更新日期:2010-08-01 00:00:00

  • Human ovarian receptors to human prolactin: implications in infertility.

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    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)46456-3

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  • Baboon corpus luteum: size and sex steroid secretion throughout the luteal phase.

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    journal_title:Fertility and sterility

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    doi:10.1016/j.fertnstert.2007.03.047

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    更新日期:2008-05-01 00:00:00

  • Rapid staining for the sperm penetration assay using a bisbenzimide dye.

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:

    authors: Bean B,Fogle TA,Gates RD

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    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2020.10.058

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  • The use of the argon laser in the treatment of experimental endometriosis.

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    doi:10.1016/s0015-0282(16)46752-x

    authors: Keye WR Jr,Matson GA,Dixon J

    更新日期:1983-01-01 00:00:00

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    pub_type: 杂志文章,评审

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    更新日期:2016-11-01 00:00:00

  • Hammen semen quality classification and pregnancies obtained during a twenty-year follow-up period.

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    doi:10.1016/j.fertnstert.2006.03.026

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    更新日期:2006-10-01 00:00:00

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2007.12.079

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    更新日期:2009-03-01 00:00:00

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    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.fertnstert.2009.03.107

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    更新日期:2010-08-01 00:00:00

  • Development and integration of an extended embryo culture program.

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    journal_title:Fertility and sterility

    pub_type: 杂志文章

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    journal_title:Fertility and sterility

    pub_type: 杂志文章,meta分析

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    journal_title:Fertility and sterility

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    doi:

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  • The effect of the biochemical marker soluble human leukocyte antigen G on pregnancy outcome in assisted reproductive technology--a multicenter study.

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    pub_type: 杂志文章,多中心研究

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    更新日期:2013-11-01 00:00:00

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    authors: Gocial B,Keye WR,Fein SH,Nardi RV

    更新日期:2000-07-01 00:00:00

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    authors: Raga F,Bonilla-Musoles F,Blanes J,Osborne NG

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    doi:10.1016/j.fertnstert.2007.06.089

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    doi:10.1016/s0015-0282(98)00245-3

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    doi:10.1016/j.fertnstert.2018.06.007

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    更新日期:2018-09-01 00:00:00

  • Are cytokines and growth factors responsible for the detrimental effects of hydrosalpingeal fluid on pregnancy rates after in vitro fertilization-embryo transfer?

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    doi:10.1016/s0015-0282(99)00422-7

    authors: Barmat LI,Nasti K,Yang X,Spandorfer S,Kowalik A,El-Roeiy A

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    更新日期:2007-07-01 00:00:00