Abstract:
OBJECTIVE:To examine the effect of body mass index (BMI) on IVF outcomes in fresh autologous cycles. DESIGN:Retrospective cohort study. SETTING:Not applicable. PATIENT(S):A total of 239,127 fresh IVF cycles from the 2008-2010 Society for Assisted Reproductive Technology registry were stratified into cohorts based on World Health Organization BMI guidelines. Cycles reporting normal BMI (18.5-24.9 kg/m(2)) were used as the reference group (REF). Subanalyses were performed on cycles reporting purely polycystic ovary syndrome (PCOS)-related infertility and those with purely male-factor infertility (34,137 and 89,354 cycles, respectively). INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Implantation rate, clinical pregnancy rate, pregnancy loss rate, and live birth rate. RESULT(S):Success rates and adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for all pregnancy outcomes were most favorable in cohorts with low and normal BMIs and progressively worsened as BMI increased. Obesity also had a negative impact on IVF outcomes in cycles performed for PCOS and male-factor infertility, although it did not always reach statistical significance. CONCLUSION(S):Success rates in fresh autologous cycles, including those done for specifically PCOS or male-factor infertility, are highest in those with low and normal BMIs. Furthermore, there is a progressive and statistically significant worsening of outcomes in groups with higher BMIs. More research is needed to determine the causes and extent of the influence of BMI on IVF success rates in other patient populations.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Provost MP,Acharya KS,Acharya CR,Yeh JS,Steward RG,Eaton JL,Goldfarb JM,Muasher SJdoi
10.1016/j.fertnstert.2015.11.008subject
Has Abstractpub_date
2016-03-01 00:00:00pages
663-669issue
3eissn
0015-0282issn
1556-5653pii
S0015-0282(15)02083-Xjournal_volume
105pub_type
杂志文章abstract::Fifty-one female volunteers used a superactive stimulatory luteinizing hormone-releasing hormone (LH-RH) analog for suppression of ovulation for 3 to 12 months. The potent LH-RH agonist D-Ser(TBU)6-EA10-LH-RH was administered intranasally once daily in a dose of 400 or 600 micrograms. No pregnancies occurred during th...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1982-08-01 00:00:00
abstract::123 healthy Jewish women (18-22 years) were divided into OC (oral contraceptives) users (n=75), and controls (n=48). All women were on a similar diet. The OC users were divided into 3 groups (1, 2 and 3) based on the OC preparations they were taking. Venous blood samples were collected; serum copper levels were mea...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)44366-9
更新日期:1979-11-01 00:00:00
abstract:OBJECTIVE:To compare sperm morphology of electrostimulated ejaculates of spinal cord-injured (SCI) men with that of manual ejaculates of an able-bodied population. DESIGN:Retrospective study. PATIENTS:Spinal cord-injured men (n = 21) participating in a reproductive rehabilitation program and able-bodied men (n = 163)...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)57561-x
更新日期:1995-05-01 00:00:00
abstract:OBJECTIVE:To evaluate FOXP3 polymorphisms (rs3761549, rs3761548, rs2232368, rs2232366, and rs2280883) in a group of infertile women with and without endometriosis and controls. DESIGN:Case control study. SETTING:Human Reproduction Outpatient Clinic of Faculdade de Medicina do ABC. PATIENT(S):The study groups were 17...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.03.033
更新日期:2011-06-01 00:00:00
abstract::Dihydrotestosterone released continuously from a subcutaneously implanted Silastic elastomer was more potent than testosterone in reducing circulating gonadotropin and androgen concentrations and in inducing testicular atrophy and infertility despite normal ejaculatory function as judged by the presence of vaginal plu...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)45566-4
更新日期:1981-06-01 00:00:00
abstract:OBJECTIVE:To report a case of laparoscopic treatment of a heterotopic primary abdominal pregnancy after IVF with preservation of the concurrent intrauterine pregnancy. DESIGN:Case report. SETTING:University-based IVF program. PATIENT(S):A woman with a heterotopic abdominal pregnancy after IVF-ET. INTERVENTION(S):Pi...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(98)00104-6
更新日期:1998-07-01 00:00:00
abstract::Whereas the dose of hMG is significantly correlated with both BMI and BW, commencing the more obese patient on higher hMG doses is not justified in view of the cancellation of cycles from over-responsiveness in the more obese patients started on higher hMG dosage regimens. If the more obese patient is slow to respond,...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55276-5
更新日期:1992-09-01 00:00:00
abstract:OBJECTIVE:To determine the levels of metabolites surrounding the human oocyte and embryo in vivo. DESIGN:Oviduct and uterine fluids were collected throughout the menstrual cycle. Cumulus cells were collected at oocyte retrieval and their production of metabolites was assessed. Samples were analyzed for pyruvate, lacta...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)58097-2
更新日期:1996-02-01 00:00:00
abstract:OBJECTIVE:To evaluate binding characteristics of a specific zona pellucida (ZP) protein 3 (ZP3) antiserum to human oocytes in order to determine its usefulness as a clinical marker for human ZP integrity and function and its correlation with IVF outcome. DESIGN:Prospectively designed, blinded, internally controlled st...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)58041-8
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:To determine the effects of a low-dose mifepristone regimen on endometrium in the rhesus monkey by endometrial staging and analysis of molecular markers of endometrial receptivity. DESIGN:A prospective, randomized comparative study. SETTING:Academic research environment. ANIMAL(S):Normally cycling rhesus (...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(00)00551-3
更新日期:2000-07-01 00:00:00
abstract::The author reports on 206 cases of endometriosis examined between 1970-1977. 172 patients had used OC (oral contraception) for a varying period of time prior to diagnosis of endometriosis; of these, 122 had taken only combined OCs containing 50 mg. or more of estrogen. These data neither support nor contradict the c...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)43887-2
更新日期:1979-03-01 00:00:00
abstract:OBJECTIVE:To report a case of monochorionic, diamniotic twin pregnancy diagnosed at 6 weeks of pregnancy with three-dimensional (3D) transvaginal sonography and to discuss the use of this diagnostic method in the evaluation of multifetal pregnancy in the first trimester. DESIGN:Case report. SETTING:University-based I...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(99)00132-6
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:To investigate whether testicular cytology by fine needle aspiration (FNA) may be considered a diagnostic parameter in the evaluation of the azoospermic subject. DESIGN:Cytologic smears were obtained using a 23-G needle, stained with May-Grünwald-Giemsa stain and examined under a light Orthoplan microscope (...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)54971-1
更新日期:1992-04-01 00:00:00
abstract:OBJECTIVE:To introduce an effective approach for excision of ovarian endometrioma by "water injection"-assisted laparoscopy treatment. DESIGN:Step-by-step video explanation of the surgical procedure with still pictures and surgical video clips to demonstrate the detailed technique, approved by the Shengjing Hospital o...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2019.05.014
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:To determine the role of parental and biological factors on the U.S. male birth fraction from 1964 through 1988. DESIGN:Logistic regression on annual U.S. male births by race group. SETTING:Population-based data. PATIENT(S):Live births in the United States 1964 through 1988. INTERVENTION(S):None. MAIN OU...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(99)00576-2
更新日期:2000-03-01 00:00:00
abstract::To explore the abnormal steroidogenesis in subjects with primary testicular failure, we measured serum levels of testosterone (T) and its precursors androstenedione (delta 4A) and 17-hydroxyprogesterone (17-OHP) in the basal state and after stimulation by human chorionic gonadotropin (hCG) for 4 hours (acute reserve) ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)46401-0
更新日期:1982-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of the immunosuppressant tacrolimus on rejection of a transplanted uterus and on uterine expression of markers of inflammation and implantation. DESIGN:Experimental study. SETTING:University laboratory. ANIMAL(S):Female rats. INTERVENTION(S):Uteri from brown Norway rats were transp...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.11.002
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:To determine the effects of smoking on eggs and subsequent embryo development by maternal exposure to cigarette smoke. DESIGN:Mice were exposed to cigarette smoke or cigarette smoke condensate (CSC) for 4 weeks and then examined for development and telomere function of embryos in vitro after fertilization. I...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.07.1781
更新日期:2009-10-01 00:00:00
abstract::To evaluate the effect of luteal estrogen supplementation on pregnancy rates in normal responder IVF patients treated with recombinant FSH and fixed multidose GnRH antagonist, patients were randomized into two groups to receive vaginal 600 mg/d micronized progesterone for luteal phase supplementation with or without t...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2007.08.029
更新日期:2008-06-01 00:00:00
abstract::The objective of this retrospective cohort study was to assess the potential effects of preconceptional short-term exposure to particulate air pollution in a real-world situation on pregnancy outcome in infertile women evaluating the possible role of IVF/embryo transfer treatment on this outcome using women who had co...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.06.031
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To review, evaluate, and synthesize current published reports assessing the value of abdominal myomectomy in infertile women and those desiring to preserve fertility potential. DATA IDENTIFICATION:Major studies dealing with myomectomy were identified through Medline Searches. STUDY SELECTION:Those papers re...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/s0015-0282(16)55128-0
更新日期:1992-07-01 00:00:00
abstract:OBJECTIVE:To study the correlation between genital phenotype and cystic fibrosis genotype in men lacking at least one vas deferens. DESIGN:Prospective study. SETTING:Institut Rhônalpin pour la Reproduction Humaine, Lyon-Bron, France. PATIENT(S):Forty-seven infertile men lacking at least one vas deferens. INTERVENTI...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(02)02954-0
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:To determine the effects of menopause (aging and E) on vaginal-cervical epithelial paracellular permeability. DESIGN:Experimental, basic clinical research. SETTING:Academic research environment. PATIENT(S):Premenopausal, perimenopausal, and postmenopausal women, aged 35-65 years. INTERVENTION(S):Primary t...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(01)02377-9
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:To examine the implantation potential of embryos from assisted reproductive technology cycles with low embryo production and to assess the effects of clinical variables and embryo scores (ES) on pregnancy outcome. DESIGN:Prospective clinical study. SETTING:Assisted reproductive technology unit in a tertiary...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2003.05.011
更新日期:2003-12-01 00:00:00
abstract::Freezing and storage of human male gametes is associated with a reduction in the overall semen quality and establishment of pregnancy. This study was done to evaluate the integrity of sperm head ultrastructure (SHU) with computerized and vapor freezing. Comparisons were made between the effect of cryopreservatives gly...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)49650-0
更新日期:1986-10-01 00:00:00
abstract:OBJECTIVE:To evaluate novel clinical markers of endometriosis including the neurotrophins brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and neurotrophin 4/5 (NT4/5) and compare them to others previously reported in the literature including cancer antigen 125 (CA-125) and C-reactive protein (CRP)....
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.09.003
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To test the efficacy of endometrial preparation with exogenous steroids, without pretreatment with gonadotropin-releasing hormone (GnRH) agonist, in women with normal ovarian function. DESIGN:Prospective randomized study. SETTING:Private outpatient infertility clinic. PATIENT(S):Two hundred ninety-six wome...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0015-0282(02)02960-6
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:To determine whether immature spermatids increase in semen in response to hormonal contraceptive treatments. Such a finding would support the existence of a defect in spermiogenesis, which in turn may explain the reported variability in sperm output. DESIGN:Semen smears were obtained from healthy men undergo...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0015-0282(97)00426-3
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To examine sperm motility, total antioxidant level (TAC), DNA fragmentation, and medical history in infertile men with high seminal high reactive oxygen species (ROS). DESIGN:Prospective study. SETTING(S):Tertiary care hospital. PATIENT(S):Infertile men (n=101). INTERVENTION(S):Group I (n=57) included men...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.12.030
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of chronic GnRH antagonist therapy on the extent of GnRH agonist-induced gonadotrope desensitization. DESIGN:Prospective and controlled. SETTING:Primate Research Center. PARTICIPANTS:Six reproductive age cycling female baboons (Papio cyanocephalus anubis). INTERVENTIONS:The animals ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)57864-9
更新日期:1995-10-01 00:00:00