Immature spermatids are not prevalent in semen from men who are receiving androgen-based contraceptive regimens.

Abstract:

OBJECTIVE:To determine whether immature spermatids increase in semen in response to hormonal contraceptive treatments. Such a finding would support the existence of a defect in spermiogenesis, which in turn may explain the reported variability in sperm output. DESIGN:Semen smears were obtained from healthy men undergoing randomized control trials of T plus progestin contraceptive treatments. PATIENT(S):Healthy men (21-49 years) with normal semen analyses received T (50-100 mg IM weekly) in combination with either desogestrel (150-300 microg daily, n = 5) or levonorgestrel (125-250 microg daily, n = 10) for 24 weeks. Semen smears were made during spermatogenic suppression and recovery. Nine control subjects were also assessed. MAIN OUTCOME MEASURE(S):Semen analyses were performed using World Health Organization criteria. Immature spermatids and white blood cells in semen were identified by immunostaining with monoclonal antibodies to the human intra-acrosomal antigen SP-10 and the ubiquitous white cell CD-45 antigen, respectively. RESULT(S):In a total of 14 normal ejaculates (9 control and 5 pretreatment) 74+/-14 million/mL sperm (mean+/-SEM) were seen together with a few immature spermatids (0.69+/-0.20 million/mL). During contraceptive treatments, spermatid number decreased in parallel with the sperm concentration and spermatids disappeared in most subjects. No significant changes were seen in either leukocyte or immunonegative round cell concentration (0.41+/-0.25 and 0.25+/-0.09 million/mL in controls, respectively) in response to treatments. CONCLUSION(S):Spermatid sloughing, as assessed by the ejaculation of immature spermatids, is not a feature of T-induced spermatogenic regression in men; rather, the decline in both mature and immature germ cells in the ejaculate probably results from a decline in the number of precursor cells, ultimately resulting in severe oligo- or azoospermia. Detailed studies on the sites of spermatogenic interruption are required to understand the variability in responses seen after contraceptive therapies in men.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Zhengwei Y,Wreford NG,Bremner WJ,Matsumoto AM,Anawalt BA,McLachlan RI

doi

10.1016/s0015-0282(97)00426-3

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

89-95

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015028297004263

journal_volume

69

pub_type

临床试验,杂志文章,随机对照试验
  • Sonographic assessment of endometrial pattern and thickness in patients treated with human menopausal gonadotropins.

    abstract:OBJECTIVE:To analyze sonographically the endometrium in patients undergoing controlled ovarian stimulation with menotropins in order to determine the significance of endometrial pattern and thickness on pregnancy rate. DESIGN:This is a prospective, nonrandomized study comparing pregnancy rates in patients with hyperec...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0015-0282(16)58447-7

    authors: Bohrer MK,Hock DL,Rhoads GG,Kemmann E

    更新日期:1996-08-01 00:00:00

  • Does the level of serum antimüllerian hormone predict ovulatory function in women with polycystic ovary syndrome with aging?

    abstract:OBJECTIVE:To determine possible prediction of regular menses with aging in anovulatory women with polycystic ovary syndrome (PCOS). DESIGN:Cohort. SETTING:Academic practice. PATIENT(S):A total of 54 anovulatory women with PCOS and 28 age- and weight-matched control subjects. INTERVENTION(S):Blood and ovarian ultras...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2012.06.017

    authors: Carmina E,Campagna AM,Mansuet P,Vitale G,Kort D,Lobo R

    更新日期:2012-10-01 00:00:00

  • Two-dimensional HyCoSy with contrast tuned imaging technology and a second-generation contrast media for the assessment of tubal patency in an infertility program.

    abstract:OBJECTIVE:To compare the efficiency of hysterosalpingo-contrast-sonography performed with air and saline (Hydro-HyCoSy) with HyCoSy performed with contrast media (SonoVue) and contrast-tuned imaging technology (CnTI-SonoVue-HyCoSy) considering hysterosalpingography (HSG) and laparoscopy (LPS) as reference tests and to ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2008.07.1746

    authors: Lanzani C,Savasi V,Leone FPG,Ratti M,Ferrazzi E

    更新日期:2009-09-01 00:00:00

  • Depression: an emotional obstacle to seeking medical advice for infertility.

    abstract:OBJECTIVE:To investigate the mental and general health of infertile women who had not sought medical advice for their recognized infertility and were therefore not represented in clinical populations. DESIGN:Longitudinal cohort study. SETTING:Population based. PATIENT(S):Participants in the Australian Longitudinal S...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2009.10.062

    authors: Herbert DL,Lucke JC,Dobson AJ

    更新日期:2010-10-01 00:00:00

  • Comparison of techniques for the selection of bacteria-free sperm preparations.

    abstract::The authors compared the three most commonly used sperm preparation techniques--swim-up, fall-down, and Percoll gradient--for their ability to recover highly motile sperm and minimize bacterial contamination. Eleven human semen samples collected by masturbation were used and run in parallel with the three methods. A s...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)59481-3

    authors: Sun LS,Gastaldi C,Peterson EM,de la Maza LM,Stone SC

    更新日期:1987-10-01 00:00:00

  • Supplementation of cryopreservation medium with TAT-Peroxiredoxin 2 fusion protein improves human sperm quality and function.

    abstract:OBJECTIVE:To investigate the potential effects of TAT-PRDX2 protein supplementation to the cryopreservation medium on post-thaw sperm quality and function. DESIGN:In vitro prospective study. SETTING:Medical university hospital. PATIENT(S):Fifty normozoospermic, 50 asthenozoospermic, and 50 oligoasthenozoospermic men...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2018.07.008

    authors: Liu J,Wang W,Liu X,Wang X,Wang J,Wang Y,Li N,Wang X

    更新日期:2018-11-01 00:00:00

  • A case of unusual course of adolescent menorrhagia: decidual cast as a side effect of treatment.

    abstract:OBJECTIVE:To present an unusual side effect of therapy for adolescent menorrhagia, with commentary on management options. DESIGN:Case report. SETTING:Tertiary gynecologic center. PATIENT(S):A 13-year-old girl presenting with profuse uterine bleeding. INTERVENTION(S):Dysfunctional uterine bleeding was diagnosed, and...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2009.07.997

    authors: Torres A,Baszak-Radomańska E,Torres K,Paszkowski T,Staśkiewicz GJ,Wozniakowska E

    更新日期:2009-11-01 00:00:00

  • Attenuated oocyte fertilization and embryo development associated with altered growth factor/signal transduction induced by endometriotic peritoneal fluid.

    abstract:OBJECTIVE:To investigate whether the embryotoxic effect of peritoneal fluid (PF) from infertile women with mild endometriosis on mouse oocytes and embryos is associated with changes in embryonic epidermal growth factor (EGF), insulin-like growth factor-I (IGF-I), and their receptors. DESIGN:Experimental animal study. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2009.11.011

    authors: Ding GL,Chen XJ,Luo Q,Dong MY,Wang N,Huang HF

    更新日期:2010-05-15 00:00:00

  • Testicular histology following chronic gonadotropin-releasing hormone agonist treatment.

    abstract::The histologic appearance of the testes of men exposed to chronic gonadotropin-releasing hormone agonist (GnRH-A) therapy has not been previously documented. Herein, we report on the histologic features of the testes of four patients with disseminated prostatic carcinoma who received at least 1 year of daily treatment...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)48205-1

    authors: Rajfer J,Swerdloff RS,Heber DM

    更新日期:1984-11-01 00:00:00

  • The patient with Turner syndrome: puberty and medical management concerns.

    abstract::Turner syndrome (TS), which affects approximately 1 in 2,500 live-born females, is characterized by loss or structural anomalies of an X chromosome. Clinical features vary among patients; multiple organ systems can be affected. Endocrinologists are involved in the management of short stature, delayed puberty, and infe...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审

    doi:10.1016/j.fertnstert.2012.07.1104

    authors: Gonzalez L,Witchel SF

    更新日期:2012-10-01 00:00:00

  • Sperm morphology evaluated by computer (IVOS) cannot predict the fertilization rate in vitro after intracytoplasmic sperm injection.

    abstract:OBJECTIVE:To evaluate sperm morphology assessment using the IVOS (Hamilton-Thorne Research Version 3 Dimension Program, Beverly, MA) system in prediction of fertilization rate in vitro after intracytoplasmic sperm injection (ICSI). DESIGN:A prospective clinical study. SETTING:Diagnostic andrology laboratory and assis...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(97)00555-4

    authors: Sukcharoen N,Sithipravej T,Promviengchai S,Chinpilas V,Boonkasemsanti W

    更新日期:1998-03-01 00:00:00

  • Reconstruction of ooplasm recipient oocytes with frozen-thawed donor microcytoplasts and influence on the microtubular spindle.

    abstract:OBJECTIVE(S):To cryopreserve micromanipulated ooplast segments (microcytoplasts) from mouse oocytes, compare microcytoplast and parent or recipient oocyte fusion performed within or without the zona pellucida, compare electrofusion of fresh or frozen oocyte with frozen-thawed microcytoplasts, and assess spindle integri...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2006.07.1529

    authors: Goud AP,Goud PT,Diamond MP,Gonik B,Dozortsev DI,Hughes MR

    更新日期:2007-04-01 00:00:00

  • Embryo transfer practices and multiple births resulting from assisted reproductive technology: an opportunity for prevention.

    abstract:OBJECTIVE:To evaluate assisted reproductive technology (ART) ET practices in the United States and assess the impact of these practices on multiple births, which pose health risks for both mothers and infants. DESIGN:Retrospective cohort analysis using the National ART Surveillance System data. SETTING:US fertility c...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2014.12.127

    authors: Kissin DM,Kulkarni AD,Mneimneh A,Warner L,Boulet SL,Crawford S,Jamieson DJ,National ART Surveillance System (NASS) group.

    更新日期:2015-04-01 00:00:00

  • Tubal transport of spermatozoa does not appear to be dependent on normal cilia function.

    abstract:OBJECTIVE:To report the case of a woman with Kartagener's syndrome with complete immotility of ciliae and normal transport of spermatozoa. DESIGN:Case report. PATIENTS:A 31-year-old woman with Kartagener's syndrome. SETTING:Medical university-affiliated teaching hospital. INTERVENTION(S):Ultrasonography, hysterosal...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2006.12.079

    authors: Ott HW,Schmiedehausen K,Kat S,Binder H,Gall C,Kuwert T,Heute D,Virgolini I,Wildt L

    更新日期:2007-11-01 00:00:00

  • Regional training program of laparoscopy: impact on regional care.

    abstract::In response to large numbers of requests for laparoscopic sterilization, the University of North Carolina began a training program to provide this service on a regional basis throughout the state. This report reviews the final distribution of centers providing these services: one within 50 miles of every person in the...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)42312-5

    authors: Hulka JF,Mercer JP,Fishburne JI,Kumarasamy T,Dingfelder JR

    更新日期:1977-01-01 00:00:00

  • In vitro action of progestogens on sperm migration in human cervical mucus;.

    abstract::The presence of progestogens in the cervical mucus suppresses and arrests sperm penetration. Using the Kremer technique, the effects of in vitro released progesterone, d-norgestrel, and cyproterone acetate were studied by inserting silicone rubber threads bearing the respective compounds into capillary tubes containin...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)40875-7

    authors: Kesserü E,Camacho-Ortega P,Laudahn G,Schopflin G

    更新日期:1975-01-01 00:00:00

  • Effective treatment of severe menstrual migraine headaches with gonadotropin-releasing hormone agonist and "add-back" therapy.

    abstract:OBJECTIVE:To determine the efficacy of treating women with severe menstrual migraine headaches with GnRH agonist (GnRH-a) therapy, alone and combined with continuous estrogen-progestin "add-back." DESIGN:Nonrandomized, prospective treatment study. SETTING:Outpatient clinic in a university medical center. PATIENT(S):...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章

    doi:10.1016/S0015-0282(97)81928-0

    authors: Murray SC,Muse KN

    更新日期:1997-02-01 00:00:00

  • The effect of 6 weeks of testosterone treatment on pulsatile luteinizing hormone secretion in eugonadal female-to-male transsexuals.

    abstract::Polycystic ovary disease generally is associated with elevated androgen levels and elevated luteinizing hormone (LH) levels, whereas follicle-stimulating hormone (FSH) levels are (sub)normal. To assess the role of androgens on gonadotropin secretion, we investigated the effect of 6 weeks of testosterone (T) undecanoat...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)54194-6

    authors: Scheele F,Hompes PG,Gooren LJ,Spijkstra JJ,Spinder T

    更新日期:1991-03-01 00:00:00

  • Prolonged stimulation with tumor necrosis factor-alpha induced partial methylation at PR-B promoter in immortalized epithelial-like endometriotic cells.

    abstract::The promoter of P receptor isoform B (PR-B) has recently been shown to be hypermethylated in endometriotic tissues, but one question remains as what causes the aberrant methylation. We show that sustained stimulation of an epithelial-like endometriotic cell line with tumor necrosis factor alpha stimulation for 30 days...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2007.06.008

    authors: Wu Y,Starzinski-Powitz A,Guo SW

    更新日期:2008-07-01 00:00:00

  • WITHDRAWN: What makes them split? Identifying risk factors that lead to monozygotic twins after in vitro fertilization.

    abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2013.08.053

    authors: Knopman JM,Krey LC,Oh C,Lee J,McCaffrey C,Noyes N

    更新日期:2013-10-07 00:00:00

  • Obstetric and perinatal outcomes of pregnancies conceived with embryos cultured in a time-lapse monitoring system.

    abstract:OBJECTIVE:To compare obstetric and perinatal outcomes of singleton pregnancies resulting from embryos incubated in a time-lapse system (TLS) with those of embryos grown in standard IVF incubators (SI). DESIGN:Retrospective description of a cohort of patients who conceived during a randomized, controlled trial. SETTIN...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.fertnstert.2017.06.031

    authors: Insua MF,Cobo AC,Larreategui Z,Ferrando M,Serra V,Meseguer M

    更新日期:2017-09-01 00:00:00

  • Survival of the cornual pregnancy in a heterotopic gestation after in vitro fertilization and embryo transfer.

    abstract::We present a case of combined intrauterine and cornual (interstitial) pregnancy after IVF-ET, with survival of the infant after the cornual pregnancy. The diagnosis of this rare phenomenon is difficult; a high index of suspicion and frequently ultrasound monitoring may enable early diagnosis in other forms of heteroto...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)53473-6

    authors: Beck P,Silverman M,Oehninger S,Muasher SJ,Acosta AA,Rosenwaks Z

    更新日期:1990-04-01 00:00:00

  • Ovarian surgery in an infertility patient as an indication for a short-interval second-look laparoscopy: a preliminary study.

    abstract::The usefulness of a short-interval second-look laparoscopy (SLL) after ovarian surgery was examined. In 23 infertile women who had either bilateral wedge resection (BWR) of polycystic ovaries, an oophorocystectomy (OC), or resection of endometriomata (RE), adhesions were graded before and after surgery and before and ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)48975-2

    authors: Pittaway DE,Daniell JF,Maxson WS

    更新日期:1985-11-01 00:00:00

  • Assessing loss of imprint methylation in sperm from subfertile men using novel methylation polymerase chain reaction Luminex analysis.

    abstract:OBJECTIVE:To assess the clinical value of bisulfite polymerase chain reaction Luminex (BPL), an automated, high-throughput procedure for the detection of alterations in DNA methylation. DESIGN:Experimental prospective study. SETTING:University research laboratory and private in vitro fertilization (IVF) clinic. PATI...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.fertnstert.2010.06.076

    authors: Sato A,Hiura H,Okae H,Miyauchi N,Abe Y,Utsunomiya T,Yaegashi N,Arima T

    更新日期:2011-01-01 00:00:00

  • Cryopreservation of human spermatozoa: correlations of ultrastructural sperm head configuration with sperm motility and ability to penetrate zona-free hamster ova.

    abstract::Freezing and storage of human male gametes is associated with a reduction in the overall semen quality and establishment of pregnancy. This study was done to evaluate the integrity of sperm head ultrastructure (SHU) with computerized and vapor freezing. Comparisons were made between the effect of cryopreservatives gly...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)49650-0

    authors: Serafini PC,Hauser D,Moyer D,Marrs RP

    更新日期:1986-10-01 00:00:00

  • Double fertilization in vitro and the origin of human chimerism.

    abstract::A human embryo consisting of two cells, each containing two pronuclei, was found in the IVF laboratory. The most likely explanation for this phenomenon is a parthenogenetic activation of an oocyte leading to immediate cleavage and followed by double fertilization. Human chimerism may originate in this way. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)53780-7

    authors: Van de Leur SJ,Zeilmaker GH

    更新日期:1990-09-01 00:00:00

  • Peritoneal fluid of patients with endometriosis promotes proliferation of endometrial stromal cells and induces COX-2 expression.

    abstract::Cell proliferation of endometrial stromal cells treated with peritoneal fluid of women (aged 25 to 43 years) with endometriosis (n = 12) statistically significantly increased compared with the control treatment (peritoneal fluid of women without endometriosis, n = 8). Also, COX-2 gene expression and prostaglandin E(2)...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2010.11.039

    authors: Liu Y,Hu J,Shen W,Wang J,Chen C,Han J,Zai D,Cai Z,Yu C

    更新日期:2011-04-01 00:00:00

  • Improved clinical outcomes for in vitro fertilization with delay of embryo transfer from 48 to 72 hours after oocyte retrieval: use of glucose- and phosphate-free media.

    abstract:OBJECTIVE:To evaluate clinical outcomes of day 2 versus day 3 ET using a culture media with no glucose or phosphate. DESIGN:Retrospective clinical study. SETTING:Hospital-based fertility clinic. PATIENT(S):One hundred seventy-six IVF-ET patients undergoing controlled ovarian supraovulation. INTERVENTION(S):IVF and ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(97)00499-8

    authors: Carrillo AJ,Lane B,Pridman DD,Risch PP,Pool TB,Silverman IH,Cook CL

    更新日期:1998-02-01 00:00:00

  • Assisted reproductive technology in the United States: 1997 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproductive Technology Registry.

    abstract:OBJECTIVE:To summarize the procedures and outcomes of assisted reproductive technology (ART) initiated in the United States in 1997. DESIGN:Data were collected electronically by using Society for Assisted Reproductive Technology Clinical Outcome Reporting System software and were submitted to the American Society for ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审

    doi:10.1016/s0015-0282(00)01559-4

    authors:

    更新日期:2000-10-01 00:00:00

  • Mutational analysis of the WNT gene family in women with Mayer-Rokitansky-Kuster-Hauser syndrome.

    abstract::The aim of this study is to determine if Müllerian agenesis has a genetic basis linked to the WNT genes. Genomic DNA analyses for mutations in the coding sequences of four members of this family in a series of 11 women with Mayer-Rokitansky-Kuster-Hauser syndrome found four variants in the coding sequence of these gen...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2008.12.006

    authors: Ravel C,Lorenço D,Dessolle L,Mandelbaum J,McElreavey K,Darai E,Siffroi JP

    更新日期:2009-04-01 00:00:00