Abstract:
:123 healthy Jewish women (18-22 years) were divided into OC (oral contraceptives) users (n=75), and controls (n=48). All women were on a similar diet. The OC users were divided into 3 groups (1, 2 and 3) based on the OC preparations they were taking. Venous blood samples were collected; serum copper levels were measured using atomic absorption spectrophotometry (Parker et al.'s method). Serum copper levels did not correlate with time of menstrual cycle for each group, and for all groups considered together. Mean serum copper level in the control group, 120 ug/100 ml +/- 15 SD (standard deviation), was significantly lower than the serum copper level of all contraceptive groups considered together. Of the 3 groups, group 3 (those taking Neogynon) showed a steady and progressive rise in serum copper level. The mechanism of action of the rise of serum copper and ceruplasmin levels following OC intake is not clear. Hypercupremia may be due to excessive absorption of copper by the intestines, to a shift of copper from tissue to blood compartment, or to both. Chronic copper intoxication could result from hypercupremia associated with chronic OC use. Studies of Wilson's disease show that severe damage could result from excessive copper deposition in various tissues. Further research should be done to determine the potential hazards of chronic copper intoxication, particularly in patients taking Neogynon.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Rubinfeld Y,Maor Y,Simon D,Modai Ddoi
10.1016/s0015-0282(16)44366-9subject
Has Abstractpub_date
1979-11-01 00:00:00pages
599-601issue
5eissn
0015-0282issn
1556-5653pii
S0015-0282(16)44366-9journal_volume
32pub_type
杂志文章abstract:OBJECTIVE:To evaluate the incidence of monozygotic twinning (MZT) in pregnancies conceived after blastocyst transfer compared to cleavage-stage transfer. DESIGN:Retrospective study. SETTING:University IVF program. PATIENT(S):All IVF patients with viable pregnancies conceived during a 4-year period. INTERVENTION(S):...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(02)04754-4
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVE:To elucidate reinitiation factors in human spermatozoa preserved in the electrolyte-free solution at 4 degrees C. SETTING:Andrology laboratory of our hospital. PATIENTS:Semen samples were obtained from patients attending our infertility clinic. INTERVENTIONS:Ejaculated sperm were centrifuged and washed usi...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)58341-1
更新日期:1996-06-01 00:00:00
abstract::Women with endometriosis typically present with pelvic pain, infertility, or an adnexal mass, and may require surgery. Treatment of endometriosis in the setting of infertility raises a number of complex clinical questions that do not have simple answers. This document replaces the 2006 ASRM Practice Committee document...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.05.031
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To investigate the possible role of phthalate, a ubiquitous chemical used in consumer products, in the pathogenesis of uterine leiomyoma. DESIGN:Experimental and prospective case-control study using human samples. SETTING:University hospital. PATIENT(S):Fifty-three women with histologic evidence of uterine...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2017.01.015
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:To determine the fertility potential of women with congenital ampullary atresia of the fallopian tube. DESIGN:Case report and review of literature. SETTING:University-affiliated tertiary care infertility clinic. PATIENT(S):Six infertile women with congenital ampullary atresia of the oviduct. INTERVENTION(...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(02)04691-5
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:To determine the effects of tibolone and continuous combined HRT (ccHRT) on parameters in the clotting cascade. DESIGN:Randomized, double-blind study. SETTING:Hemostasis unit of a university hospital clinic in Germany. PATIENT(S):Sixty healthy postmenopausal women. INTERVENTION(S):Twenty-nine subjects wer...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0015-0282(00)00587-2
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVE:To examine the relation between blood found on the transfer catheter after ET and the rates of embryo implantation and clinical pregnancy with the use of IVF-ET. DESIGN:Retrospective cohort study. SETTING:A tertiary care center for assisted reproductive technology. PATIENT(S):Three hundred seven couples wh...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(98)00315-x
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVE:To report on a one-year experience participating in a capitated healthcare plan for infertility. DESIGN:Prospective study. SETTING:University population. PATIENT(S):Reproductive-age women 15 to 50 years. INTERVENTION(S):The first-generation Lewin infertility algorithm and CATHI software were used to negot...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(01)01673-9
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVE:To determine whether IgG subclass patterns differed between nonpregnant women, healthy pregnant women, and pregnant women with a history of recurrent miscarriage. DESIGN:Controlled clinical study. SETTING:An academic setting. PATIENT(S):Group 1 was comprised of 10 nonpregnant women, group 2 of 10 healthy p...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(01)02857-6
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVE:To determine the efficacy of treating women with severe menstrual migraine headaches with GnRH agonist (GnRH-a) therapy, alone and combined with continuous estrogen-progestin "add-back." DESIGN:Nonrandomized, prospective treatment study. SETTING:Outpatient clinic in a university medical center. PATIENT(S):...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/S0015-0282(97)81928-0
更新日期:1997-02-01 00:00:00
abstract:OBJECTIVE:We previously reported an antipeptide antibody to human glycodelin that recognizes glycodelin in amniotic fluid and epithelial glands of the endometrium. The objective of this study was to determine the presence of glycodelin in human umbilical cord. DESIGN:Controlled clinical study. SETTING:Healthy women u...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(99)00599-3
更新日期:2000-04-01 00:00:00
abstract::In a rat model, sodium carboxymethylcellulose (SCMC) was compared with normal saline and 32% dextran 70 in the prevention of surgically induced intraperitoneal adhesions. The 32% dextran 70 was similar to normal saline in the initial prevention of adhesions, and both appeared less effective than SCMC. After lysis of t...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)47910-0
更新日期:1984-06-01 00:00:00
abstract::The reproductive history of 19 women with a diagnosis of unicornuate uterus confirmed by laparoscopy or laparotomy is analyzed. The patients were followed for 2 to 10 years. One patient had a cavitary communicating rudimentary horn, four a cavitary noncommunicating rudimentary horn, seven a noncavitary rudimentary hor...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)59047-5
更新日期:1987-03-01 00:00:00
abstract:OBJECTIVE:To reanalyze the results of using FSH alone and hMG during IVF treatment, taking into account the different protocols of administration of superactive GnRH agonist analogs. DESIGN:Meta-analysis. SETTING:The London Women's Clinic. PATIENT(S):Women undergoing IVF treatment. INTERVENTION(S):A meta-analysis o...
journal_title:Fertility and sterility
pub_type: 杂志文章,meta分析
doi:10.1016/s0015-0282(99)00519-1
更新日期:2000-02-01 00:00:00
abstract:OBJECTIVE:To evaluate a new technique designed to improve access to the endometrial cavity through tortuous and/or stenotic endocervical canals in women with histories of difficult IUIs, ETs, or endometrial biopsies. DESIGN:Prospective case series. SETTING:Tertiary care center. PATIENT(S):Women with histories of dif...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(99)00492-6
更新日期:2000-02-01 00:00:00
abstract:OBJECTIVE:To report the feasibility of ovarian cyst enucleation by using a laparoendoscopic single-site trocar through a transumbilical access. DESIGN:Case reports. SETTING:Teaching and research hospital. PATIENT(S):Three patients affected by large ovarian cysts. INTERVENTION(S):Enucleation of three large ovarian c...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.05.060
更新日期:2009-09-01 00:00:00
abstract::During hysteroscopy the uterus may be distended with carbon dioxide (CO2), nitrous oxide (N2O), or Hyskon (a high molecular weight dextran). An initial study in 27 patients (group 1) using arterialized venous blood samples demonstrated rises in carbon dioxide tension (PCO2) when N2O was insufflated by using a laparosc...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)44179-8
更新日期:1979-08-01 00:00:00
abstract:OBJECTIVE:To determine whether the peripheral blood concentration of CD56(+)/CD16(-)/CD3(-) cells, the main natural killer (NK) subpopulation that colonizes the endometrium in the middle and late secretory phase, can be related to fertility or infertility status. DESIGN:A case control study. SETTING:Immunopathology d...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(03)00778-7
更新日期:2003-09-01 00:00:00
abstract::Cell-mediated immunity in rhesus monkeys that had been vasectomized for 2, 4, 7, or 11 years was measured by lymphocyte blastogenesis following stimulation with concanavalin A, phytohemagglutinin (PHA), and pokeweed mitogens. Several of the 7- and 11-year vasectomized animals had significantly reduced PHA reactivity w...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)42983-3
更新日期:1977-12-01 00:00:00
abstract:OBJECTIVE:To investigate endometrial scratch injury (ESI) as an intervention to improve IVF outcome in women undergoing a first ET. DESIGN:Systematic review and meta-analysis. SETTING:Not applicable. PATIENT(S):Infertile women undergoing a first fresh/frozen embryo transfer. INTERVENTION(S):We included published an...
journal_title:Fertility and sterility
pub_type: 杂志文章,meta分析
doi:10.1016/j.fertnstert.2018.12.008
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:To identify factors associated with cancer treatment-induced amenorrhea and time to return of menses. DESIGN:Population-based cohort study. SETTING:Not applicable. PATIENT(S):Female cancer survivors who were diagnosed with cancer between the ages of 20 and 35 and were at least 2 years postdiagnosis at the ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.11.020
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:To visualize by microhysteroscopy any possible lesions on the endocervix and endometrium made by the catheters commonly used for embryo transfer (ET). DESIGN:Prospective descriptive study. Tertiary fertility center (IFER). PATIENT(S):Twenty-three infertile patients underwent a mock transfer before a microhy...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(03)00607-1
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVE:To evaluate clinical outcomes of day 2 versus day 3 ET using a culture media with no glucose or phosphate. DESIGN:Retrospective clinical study. SETTING:Hospital-based fertility clinic. PATIENT(S):One hundred seventy-six IVF-ET patients undergoing controlled ovarian supraovulation. INTERVENTION(S):IVF and ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)00499-8
更新日期:1998-02-01 00:00:00
abstract:OBJECTIVE:To study the differences in the cleavage time between types of embryo chromosomal abnormalities and elaborate algorithm to exclude aneuploid embryos according to the likelihood to be euploid. DESIGN:Retrospective cohort study. SETTING:University affiliated private center. PATIENT(S):Preimplantational genet...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2016.09.019
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To investigate the parameters of mosaicism and the biological mechanisms leading to healthy pregnancies from mosaic embryo transfers. DESIGN:Prospective study. SETTING:IVF center and associated research laboratory. PATIENT(S):Fifty-nine patients. INTERVENTION(S):Embryos underwent blastocyst-stage preimpla...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2018.10.019
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:To develop and validate a specific simple measure of insulin sensitivity using oral glucose tolerance test (OGTT) values for lean polycystic ovary syndrome (PCOS) women. DESIGN:Retrospective study. SETTING:Gynecologic Outpatient Clinic of University Hospital, affiliated with Unit of Gynecologic Endocrinolog...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2014.04.004
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To study the role of a synthetic insulin-like growth factor-I receptor (IGF-IR) antagonist, picropodophyllin, for mouse preimplantation embryo development in vivo and in vitro. DESIGN:In vitro and in vivo study. SETTING:Hospital-based research unit. ANIMALS:FVB/N mice and mouse embryos. INTERVENTION(S):Th...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.12.044
更新日期:2010-05-15 00:00:00
abstract:OBJECTIVE:To assess the correlation between in vitro fertilization (IVF) and complications of the third stage of labor. DESIGN:Retrospective cohort of vaginal deliveries from November 2008 to January 2020. Maternal and obstetric outcomes of singleton deliveries were compared between IVF and non-IVF pregnancies. SETTI...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2020.10.004
更新日期:2020-11-30 00:00:00
abstract:OBJECTIVE:To evaluate whether stimulation of endometrium embryo transfer (SEET) can improve implantation rate and pregnancy rate (PR) for patients undergoing assisted reproductive technology (ART) for the first time by injecting embryo culture supernatant into the uterus before blastocyst transfer (BT). DESIGN:Randomi...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2008.08.076
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:To investigate the success rate of proximal tubal occlusion with Essure devices in subfertile women with hydrosalpinges, and to observe the results of subsequent treatment with IVF. DESIGN:Prospective, single-arm, clinical study. SETTING:University hospital and teaching hospital. PATIENT(S):Ten women with ...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/j.fertnstert.2008.11.022
更新日期:2010-03-01 00:00:00