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Selective insulin-like growth factor-I antagonist inhibits mouse embryo development in a dose-dependent manner.

Abstract：

OBJECTIVE:To study the role of a synthetic insulin-like growth factor-I receptor (IGF-IR) antagonist, picropodophyllin, for mouse preimplantation embryo development in vivo and in vitro. DESIGN:In vitro and in vivo study. SETTING:Hospital-based research unit. ANIMALS:FVB/N mice and mouse embryos. INTERVENTION(S):The effect of picropodophyllin in mouse embryo development in vivo and in vitro, immunohistochemistry, ELISA, polymerase chain reaction. MAIN OUTCOME MEASURE(S):Embryo development, presence of IGF-IR, messenger RNA expression, IGF-I synthesis. RESULT(S):The effect of picropodophyllin on embryo development in vitro and in vivo was not reversible. Mice treated with picropodophyllin 1 to 3 days after mating had a reduced number of blastocysts, 40.5% versus 78.8%, and a higher number of embryos with delayed development, 48.6% versus 11.5%. Insulin-like growth factor-IR protein is present in both phosphorylated and nonphosphorylated form at all stages of embryo development. The relative IGF-IR messenger RNA expression was highest in the oocyte and reduced during development to blastocyst stage. Insulin-like growth factor-I in culture media was reduced after picropodophyllin treatment. CONCLUSION(S):We conclude that IGF-I has an important role in normal mouse embryo development and that its receptor plays an essential role in the embryonic genome activation process.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Inzunza J,Danielsson O,Lalitkumar PG,Larsson O,Axelson M,Töhönen V,Danielsson KG,Stavreus-Evers A

doi

10.1016/j.fertnstert.2009.12.044

subject

Has Abstract

pub_date

2010-05-15 00:00:00

pages

2621-6

issue

8

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(09)04293-9

journal_volume

93

pub_type

杂志文章

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