Abstract:
:Most oocyte donation programs have experienced higher pregnancy rates than usually seen in regular in vitro fertilization (IVF), suggesting that the quality of either the oocytes or the endometrium is superior. To clarify this issue we analyzed the results of transfers of 136 cryopreserved embryos originating either from donated oocytes (18 transfers) or from regular IVF (118 transfers). Transfers of embryos originating from donated oocytes took place after administrating oral estradiol (E2) valerate and vaginal micronized progesterone (P) following a regimen designed to mimic the serum levels of E2 and P observed during the menstrual cycle. Transfers of embryos originating from regular IVF took place either in the natural cycle (53 transfers) or after suppressing ovarian function with a single injection of a gonadotropin-releasing hormone agonist (GnRH-a), Decapeptyl-Retard 3.75 mg, and administering the same hormone replacement regimen (E2/P) used in oocyte donation (65 transfers). Eighteen transfers involving 24 embryos originating from donated oocytes were affected, resulting in six pregnancies (4 ongoing). The ongoing pregnancy rate per transfer was 22%. Seventy-nine embryos originating from regular IVF were transferred (53 transfers) in the natural cycle resulting in six pregnancies (2 ongoing). One hundred three other embryos originating from regular IVF were transferred (65 transfers) after administration of GnRH-a and E2/P resulting in four pregnancies. The pregnancy rate after transfers of embryos originating from regular IVF was 9% per transfer. This was significantly less than the pregnancy rate of 33% per transfer seen after the transfers of embryos originating from donated oocytes.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
de Ziegler D,Frydman Rdoi
10.1016/s0015-0282(16)53830-8subject
Has Abstractpub_date
1990-10-01 00:00:00pages
682-8issue
4eissn
0015-0282issn
1556-5653pii
S0015-0282(16)53830-8journal_volume
54pub_type
杂志文章abstract:OBJECTIVE:To evaluate sperm morphology assessment using the IVOS (Hamilton-Thorne Research Version 3 Dimension Program, Beverly, MA) system in prediction of fertilization rate in vitro after intracytoplasmic sperm injection (ICSI). DESIGN:A prospective clinical study. SETTING:Diagnostic andrology laboratory and assis...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)00555-4
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between sperm chromatin defects, evaluated by the flow cytometric (FCM) sperm chromatin structure assay (SCSA), and the probability of a pregnancy in a menstrual cycle (fecundability). DESIGN:Follow-up study. SETTING:The Section of Toxicology and Biomedical Sciences, ENEA Casacci...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(99)00462-8
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To investigate the utility of random anti-Müllerian hormone (AMH) in assessing ovarian response among women with diminished ovarian reserve (DOR) diagnosed by elevated early follicular-phase FSH levels. DESIGN:Retrospective study. SETTING:Academic and academically affiliated assisted reproductive technology...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.03.071
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:To identify and treat the gamete responsible for complete fertilization failure with intracytoplasmic sperm injection (ICSI) using a newly proposed assisted gamete treatment (AGT). DESIGN:Prospective cohort study. SETTING:Center for reproductive medicine. PATIENT(S):One-hundred and fourteen couples with an...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2020.04.044
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:To describe the prevalence of hysteroscopic findings and histologic diagnoses in patients with abnormal uterine bleeding (AUB). DESIGN:Retrospective series of consecutive patients. SETTING:Tertiary care university hospital and private office. PATIENT(S):Four thousand fifty-four hysteroscopies with biopsy i...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.05.045
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To investigate whether quantitative analysis performed on one testicular specimen is adequate for quantitative evaluation of spermatogenic process. DESIGN:Comparison of quantitative analysis of spermatogenic cell types in testicular cytologic aspirates of various sites of each testis. SETTING:In each aspira...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)57741-3
更新日期:1995-08-01 00:00:00
abstract:OBJECTIVE:To determine whether retinoic acid (RA) can regulate the expression of interleukin (IL)-6 in human endometrial cells in a manner that might be beneficial to women with endometriosis. DESIGN:In vitro study. SETTING:Academic medical center. PATIENT(S):Patients with endometriosis and controls. INTERVENTION(S...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(00)00483-0
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVE:To report a case of parasitic leiomyoma of the abdominal wall after laparoscopic myomectomy. DESIGN:Case report. SETTING:Large medical center. PATIENT(S):A 31-year-old woman with a newly developed palpable mass in the abdominal wall near the trocar site of a previous laparoscopic myomectomy. INTERVENTION(...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.08.068
更新日期:2008-10-01 00:00:00
abstract::Fifty healthy women, aged 18-39 years with no known risk of ovarian hyperstimulation were treated with 100 or 150 μg corifollitropin alfa (dependent on body weight) in a long GnRH agonist protocol. At these doses, corifollitropin alfa initiated and supported growth of a large cohort of follicles during the first week ...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/j.fertnstert.2009.12.070
更新日期:2010-10-01 00:00:00
abstract::The penetration of a gonadotropin-releasing hormone agonist (GnRH-a), Buserelin (Hoechst AG, Frankfurt, West Germany), into human follicular fluids (FF) was studied by means of a radioimmunoassay (RIA) and a bioassay. Acute nasal administration of a therapeutic dose of Buserelin (300 and 600 micrograms) before the ovu...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60852-x
更新日期:1989-08-01 00:00:00
abstract::The concentrations of pregnanediol-3-glucuronide (PGD) and pregnanolone (PN) were measured in daily morning urine specimens from 66 infertile women (40 with varying degrees of endometriosis and 26 control subjects) and correlated with daily changes in basal body temperature (BBT) and with midluteal levels of serum pro...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1983-11-01 00:00:00
abstract:OBJECTIVE:To present a case of Marfan syndrome and concurrent congenital obstructive azoospermia. DESIGN:Case report. SETTING:Tertiary-care academic hospital. PATIENT(S):A man with Marfan syndrome and obstructive azoospermia. INTERVENTION(S):The patient was evaluated for azoospermia that was proved to be due to con...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(01)02868-0
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVE:To estimate the potential annual cost savings of methotrexate (MTX) therapy for ectopic pregnancy (EP) at our institution and nationally. DESIGN:Retrospective. SETTING:San Francisco General Hospital. PATIENTS:All patients treated for EP in 1991. INTERVENTIONS:Medical records and billing statements were re...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:To compare levels of apoptosis in granulosa cells from women treated with the gonadotropin-releasing hormone (GnRH) agonist triptorelin or the GnRH antagonist cetrorelix. DESIGN:Randomized, prospective study. SETTING:University hospital. PATIENT(S):Thirty-two women undergoing assisted reproduction techniqu...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2005.08.020
更新日期:2006-02-01 00:00:00
abstract::The basal body temperature (BBT) charts in pregnancy cycles of 110 consecutive women who became pregnant by a single heterologous insemination were studied. The occurrence of ovulation was proved by the pregnancies in each case. All of these pregnancy charts showed a biphasic pattern, and most followed one of three st...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)46577-5
更新日期:1982-10-01 00:00:00
abstract:OBJECTIVE:To compare the effect of high serum E(2) levels on endometrial steroid receptors in gonadotropin-stimulated cycles (hCG + 7) and natural cycles (LH + 7), and to study its effect on spheroid attachment. DESIGN:Observational. SETTING:University hospital. PATIENT(S):Infertile patient with normal menstrual cyc...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.06.015
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:To present the success rates of assisted reproductive technologies (ART) cycles performed in 2001 in Canada. DESIGN:Retrospective cohort study. SETTING:Nineteen of 22 ART centers in Canada. PARTICIPANTS:Couples undergoing ART treatment in Canada during 2001. METHODS:Data on each ART cycle performed during...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.03.037
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVE:To study the psychological effects of multifetal pregnancy reduction. DESIGN AND SETTING:Hour-long semistructured telephone interviews with both multifetal pregnancy reduction patients and control subjects. PATIENTS:Forty-two multifetal pregnancy reduction patients were contacted within 1 year of undergoing...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
abstract::The effectiveness of Buserelin (Hoechst-Roussel Pharmaceuticals, Inc., Somerville, NJ) (0.2 mg subcutaneously [SC] or 1.2 mg intranasally [IN] per day) and danazol (800 mg per day) in inducing ovarian suppression for the management of endometriosis was compared in a prospective randomized study. During 6 months of tre...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0015-0282(16)60543-5
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVE:To determine if increases in core body temperature preceding most hot flashes are caused by increased metabolic rate, peripheral vasoconstriction, or central noradrenergic activation. DESIGN:Laboratory physiological study. SETTING:University medical center. PATIENT(S):Fourteen healthy, postmenopausal women...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(98)00137-x
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:To analyze the HOXA10 genes in CAUV patients for mutations. Congenital absence of the uterus and vagina (CAUV) is the most extreme female reproductive tract developmental defect known. The HOXA10 gene is expressed in the developing and adult uterus. Female mice with loss-of-function Hoxa10 gene mutations have...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.03.033
更新日期:2008-02-01 00:00:00
abstract::The number of live births from IVM oocytes has been increasing over the past two decades. Data concerning the health of IVM infants are reported by the authors of this Views and Reviews. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2013.02.044
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:To determine the influence of estrogens on male fertility. DESIGN:A 36-year-old eugonadal male was subjected to two different regimens of treatment with ethinyl estradiol (EE2). Sperm quality, immunoreactive luteinizing hormone (LH) and follicle-stimulating Hormone (FSH), testosterone (T), estrone (E1), estr...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55271-6
更新日期:1992-09-01 00:00:00
abstract:OBJECTIVE:To report a live birth of twins from autologous zona-free oocytes. DESIGN:Case report. SETTING:Reproductive endocrinology and infertility private practice and ambulatory in vitro fertilization (IVF) center. PATIENT(S):A 34-year-old woman, gravida 0, with 100% zona-free oocytes. INTERVENTION(S):IVF with in...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2016.01.023
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:The tissue-bound ovarian renin-angiotensin system (OVRAS) is critically involved in ovulation in humans and rodents. Mice with disruption and overexpression of the angiotensinogen gene (Agt) have been previously generated. We investigated the influence of varying Agt gene expression on the ovulatory capacity ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(01)01797-6
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVE:To determine whether complete failure of fertilization of oocytes in couples with unexplained infertility persists during subsequent in vitro fertilization (IVF) cycles. DESIGN:A retrospective study of 120 cycles of IVF in 44 couples with unexplained infertility and complete failure of fertilization during t...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55677-5
更新日期:1993-02-01 00:00:00
abstract::The predictive value of the metoclopramid-provocation test to detect transient hyperprolactinemia during cycle stimulation was assessed. Patients developing hyperprolactinemia during cycle stimulation showed a significantly higher PRL response to the metoclopramid-provocation test before cycle stimulation. The current...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53300-7
更新日期:1990-02-01 00:00:00
abstract:OBJECTIVE:To report a dichorionic quadramniotic quadruple gestation with monochorionic triamniotic triplets after intracytoplasmic sperm injection (ICSI) treatment and transfer of two embryos. DESIGN:Case report. SETTING:Academic reproductive medicine center. PATIENT(S):A 28-year-old nulligravida who underwent first...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.08.022
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of cryopreservation storage duration on embryo survival, implantation competence, and pregnancy outcome. DESIGN:Retrospective study. SETTING:Academic tertiary-referral infertility center. PATIENT(S):In vitro fertilization patients and recipients of oocyte donation cycles who had cryo...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.09.084
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To analyze the data available on the biologic significance of white blood cells (WBC) in semen of infertility patients. DATA RESOURCES:The relevant literature was reviewed. RESULTS:It is not possible to identify reliably WBC by conventional sperm staining techniques. The peroxidase method is sufficient for ...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/s0015-0282(16)57588-8
更新日期:1995-06-01 00:00:00