Abstract:
OBJECTIVE:To evaluate the importance of exogenous LH in poor responders undergoing IVF with GnRH antagonists. DESIGN:Retrospective cohort study. SETTING:University-based IVF center. PATIENT(S):All patients with a history of poor response to ovarian stimulation undergoing IVF with GnRH antagonists between September 2000 and August 2001. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Clinical pregnancy rates. RESULT(S):Two hundred forty GnRH-antagonist cycles were initiated in poor responders. One hundred fifty-three progressed to oocyte retrieval. Seventy-five patients received recombinant FSH (Rec) for ovarian stimulation, and 66 received hMG in combination with Rec. In patients aged <40 years, there were no significant differences in amount and duration of treatment, number of oocytes retrieved, and number of embryos between treatment groups. In patients aged > or =40 years, significantly fewer oocytes were retrieved in groups who received exogenous LH in their stimulation, resulting in significantly fewer fertilized embryos. Implantation and clinical pregnancy rates did not differ by treatment group. CONCLUSION(S):In poor responders undergoing IVF with GnRH antagonists, outcomes are comparable whether stimulation is achieved in the presence or absence of supplemental LH. Exogenous LH does not appear to be necessary to achieve pregnancy in these challenging patients and may be detrimental to older patients with a history of poor response.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Chung K,Krey L,Katz J,Noyes Ndoi
10.1016/j.fertnstert.2005.02.028keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
313-8issue
2eissn
0015-0282issn
1556-5653pii
S0015-0282(05)00917-9journal_volume
84pub_type
杂志文章abstract:OBJECTIVE:To evaluate the association between leiomyomas and estrogen receptor gene polymorphism. DESIGN:Prospective study. SETTING:Department of gynecology and genetics. PATIENT(S):Women with (n = 159) or without leiomyomas (n = 131). MAIN OUTCOME MEASURE(S):Polymerase chain reaction was used to detect dinucleotid...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(02)04563-6
更新日期:2003-01-01 00:00:00
abstract::The alkaloids ergocornine, vinblastine, and colcemide, with reported effects interfering with ovum implantation and development were investigated in the white New Zealand rabbit and the macaque monkey. 3 antimetabolites, 5-fluorouracil, 6-azauridine, and BW 57-323H, the 6 mercaptopurine derivative, were also investig...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)36181-7
更新日期:1967-01-01 00:00:00
abstract:OBJECTIVE:To determine association between health-related quality of life (HRQOL) and psychosexual variables in patients with polycystic ovary syndrome (PCOS). DESIGN:Cross-sectional study. SETTING:Two private gynecology clinics. PATIENT(S):A sample of 300 women with PCOS were entered into the study and were subdivi...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究
doi:10.1016/j.fertnstert.2013.06.043
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of idiopathic hirsutism among a population of consecutive hirsute patients. DESIGN:Prospective cohort study. SETTING:University-based clinic. PATIENT(S):Premenopausal women with a complaint of hirsutism who were not receiving hormonal therapy. INTERVENTION(S):Evaluations for to...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(98)00141-1
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:To understand the barriers that serodiscordant couples with human immunodeficiency virus (HIV) face in accessing services for risk reduction and infertility using assisted reproductive technology (ART). DESIGN:Two-arm cross-sectional telephone "secret shopper" study. SETTING:Infertility clinics designated b...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2017.11.039
更新日期:2018-03-01 00:00:00
abstract::The authors define and discuss the various forms taken by duplicate publications, and provide suggested remedies to help authors, editors, reviewers, and readers avoid this form of internal plagiarism. ...
journal_title:Fertility and sterility
pub_type: 社论
doi:10.1016/j.fertnstert.2005.01.009
更新日期:2005-04-01 00:00:00
abstract::To our knowledge, this represents the first case of a laparoscopically treated triplet EP and the first time that a double EP in the same tube was treated conservatively (with preservation of the tube). Multiple EPs may be more common than currently thought, and our report offers an alternative explanation for at leas...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53960-0
更新日期:1990-11-01 00:00:00
abstract::The aim of the present study was to compare the levels of leukemia inhibitory factor (LIF) in the tubal ampullary region in normal and ectopic pregnancies and assess possible causative role of LIF in ectopic pregnancy. Although there was a tendency of increase in LIF concentrations in the ectopic pregnancy group, we w...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2004.09.014
更新日期:2005-02-01 00:00:00
abstract::Technical advances in massive parallel sequencing have allowed the characterization of the whole reproductive tract microbiome in all the compartments beyond the vagina. The microbiota in the uterine cavity seem to be a continuum from the microbiota in the vagina, but several works have reported significant difference...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2018.04.041
更新日期:2018-08-01 00:00:00
abstract::In this prospective, randomized study, waiting for the lead follicle to reach 14 mm before initiating GnRH antagonist administration effectively prevents an LH surge and ovulation during an IVF cycle. Furthermore, delaying GnRH start until the dominant follicle reaches 14 mm neither impacts the clinical pregnancy, imp...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2009.05.083
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:To develop a consensus regarding the need for luteal phase support during assisted reproductive technology (ART), and to establish the optimal compound and route of administration for this purpose. DESIGN:Review of the published literature on luteal phase support. PATIENT(S):Women undergoing assisted reprod...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/s0015-0282(01)02961-2
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVE:To measure the levels of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) induced by thrombin in endometrial stromal cells (ESC). DESIGN:Evaluation of the effects of thrombin, thrombin receptor activator peptide 6 (TRAP-6), and D-phenylalanyl-1-propyl-L arginine chloromethyl ket...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.11.080
更新日期:2009-02-01 00:00:00
abstract::In response to large numbers of requests for laparoscopic sterilization, the University of North Carolina began a training program to provide this service on a regional basis throughout the state. This report reviews the final distribution of centers providing these services: one within 50 miles of every person in the...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)42312-5
更新日期:1977-01-01 00:00:00
abstract::The transcervical division of uterine septa is usually described as a simple procedure associated with minimal morbidity. Two cases are presented describing late hemorrhage after this procedure. Approaches to avoiding this complication as well as management principles are described. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)54984-x
更新日期:1992-04-01 00:00:00
abstract::Semen analyses were performed and serum and seminal plasma prolactin (PRL) concentrations were determined in 165 samples from 120 men seen with their wives because of infertility. The mean (+/- standard deviation) serum and seminal plasma PRL concentrations were 6.5 +/- 3.3 and 7.5 +/- 3.1 ng/ml, respectively. The mea...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)59664-2
更新日期:1988-01-01 00:00:00
abstract::The authors review the current approach to management of the adolescent varicocele which has evolved over the past two decades. Principles of observational, surgical and adjunctive management are discussed relative to significant clinical findings. A selective approach to surgical intervention is advocated with the go...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2011.10.034
更新日期:2011-12-01 00:00:00
abstract::Forty-one subjects with hyperprolactinemia underwent testing on separate occasions with nomifensine, an indirectly acting dopamine agonist, and domperidone, a dopamine receptor-blocking agent. Nomifensine (200 mg orally) did not significantly modify plasma levels of prolactin (PRL) in 17 subjects in whom the existence...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)45314-8
更新日期:1981-02-01 00:00:00
abstract::The effect of different concentrations of prolactin (0 to 60 ng) on the release of tetracycline from human spermatozoa labeled with 7-3H-tetracycline hydrochloride was studied. Prolactin significantly enhanced the release of bound tetracycline, indicating that prolactin may influence the processes associated with sper...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)43219-x
更新日期:1978-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the potential clinical application of Raman spectroscopy (RS) as a tool that may identify spermatogenesis within human seminiferous tubules. DESIGN:RS scanning of human testicular tissue at different maturational stages; immunohistochemistry study and metabolomic analysis of nonobstructive azoosp...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2014.03.035
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To report three cases of interstitial pregnancies treated successfully by combining uterine artery embolization (UAE) and ultrasound-guided local administration of methotrexate (MTX); and to assess the effect of UAE on ovarian reserve by prospectively measuring serum antimüllerian hormone (AMH) levels. DESIG...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.03.087
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:To examine proteins aberrantly expressed in the ectopic endometrium compared with eutopic endometrium from the same patient. DESIGN:Experimental study. SETTING:Research institute and an obstetrics and gynecology clinic (National Institute for Research in Reproductive Health and Sanjeevani Diagnostic Center ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.01.048
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:To quantify the in vitro effects of gonadotropins on benign, borderline, and malignant ovarian cell lines. DESIGN:In vitro cell culture. SETTING:Research laboratory. PATIENT(S):None. INTERVENTION(S):Three hormonally sensitive ovarian neoplastic cell lines were exposed to control medium, FSH (40 mIU/mL), h...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(02)03367-8
更新日期:2002-11-01 00:00:00
abstract::In this study, acrosin activity and hyaluronic acid binding were compared in sperm from men with spinal cord injury versus sperm from healthy controls. The results showed statistically significantly lower acrosin activity and statistically significantly lower hyaluronic acid binding in spinal cord injured patients com...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.01.015
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To establish a nonhuman primate model addressing follicular development in cryopreserved prepubertal ovarian tissue after xenografting. DESIGN:Experimental study. SETTING:Academic research center. ANIMAL(S):Ovarian tissue from female prepubertal common marmoset (Callytrix jacchus jacchus) grafted into immu...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.11.003
更新日期:2011-03-15 00:00:00
abstract:OBJECTIVE:To describe the prevalence of annexin V antibodies (aANX) in women with early recurrent pregnancy losses (RPLs) or recurrent IVF-ET failure. DESIGN:Retrospective data analysis. SETTING:Tokai University Hospital, Kanagawa, Japan. PATIENT(S):Two hundred thirty-eight patients with RPLs, 48 patients with recur...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(01)02009-x
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:To measure IVF effectiveness, which is defined as the cumulative incidence of live delivery over real time in women after commencing IVF treatment. DESIGN:Population-based retrospective cohort study. SETTING:IVF clinics in Western Australia (WA). PATIENT(S):All women ages 20-44 years inclusive at start of ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.01.130
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To determine whether monocyte chemotactic protein-1 (MCP-1), a proinflammatory chemokine important in ovulation, is abnormally elevated in obese women undergoing IVF and whether serum and follicular fluid (FF) levels of MCP-1 are associated with IVF outcome. DESIGN:Prospective pilot study. SETTING:Academic ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2016.12.023
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:To study nucleation status in two- and four-cell embryos and its effect on reproductive outcomes. DESIGN:Retrospective cohort study. SETTING:University-affiliated private center. PATIENT(S):A total of 1,679 embryos from 940 oocyte donation cycles from May 2012 to May 2014. INTERVENTION(S):None. MAIN OUTC...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2016.03.036
更新日期:2016-08-01 00:00:00
abstract::A monoclonal antibody that induces agglutination of human sperm was used to localize the interacting antigen in various tissues by indirect immunofluorescence. The antibody localized to the immature sperm and Sertoli cells of the seminiferous tubules, simple cuboidal epithelial cells of the rete testis, and the column...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)48147-1
更新日期:1984-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of elagolix, an oral GnRH antagonist, for the reduction of fatigue in women with moderate or severe endometriosis-associated pain. DESIGN:Randomized, double-blind, multicenter, placebo-controlled phase III trial. SETTING:Clinics. PATIENT(S):A total of 860 women treated with elagoli...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.fertnstert.2019.02.031
更新日期:2019-08-01 00:00:00