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Study of nucleation status in the second cell cycle of human embryo and its impact on implantation rate.

Abstract：

OBJECTIVE:To study nucleation status in two- and four-cell embryos and its effect on reproductive outcomes. DESIGN:Retrospective cohort study. SETTING:University-affiliated private center. PATIENT(S):A total of 1,679 embryos from 940 oocyte donation cycles from May 2012 to May 2014. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Implantation, morphokinetics, and nucleation status restoration. RESULT(S):Multinucleation was present in 42.53% of embryos with known implantation data at the two-cell stage; it was present in approximately 14% of them at the four-cell stage. In all, 73.4% of the embryos were multinucleated at two cells and restored their nucleation status when they cleaved into four cells. Embryos with blastomeres multinucleated (more than two nuclei) at the four-cell stage showed a lower implantation rate. The average length of S-phase in the first embryo cell cycle in the positive known implantation data (KID+) embryos was longer than in KID- (15.50 hours vs. 14.38 hours) and slightly shorter in the second embryo cell cycle (8.35 hours in KID+ vs. 8.60 hours in KID-). CONCLUSION(S):Multinucleation in two-cell-stage embryos is a frequent event, which is reversible in a high proportion of embryos, without impact on the implantation rate; and embryos with multinucleated blastomeres have a reduced outcome compared with those with binucleated blastomeres when multinucleation is present in four-cell-stage embryos.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Aguilar J,Rubio I,Muñoz E,Pellicer A,Meseguer M

doi

10.1016/j.fertnstert.2016.03.036

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

291-299.e2

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)61043-9

journal_volume

106

pub_type

杂志文章

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