当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > Endocrine gland-derived vascular endothelial growth factor concentrations in follicular fluid and serum may predict ovarian hyperstimulation syndrome in women undergoing controlled ovarian hyperstimulation.

Endocrine gland-derived vascular endothelial growth factor concentrations in follicular fluid and serum may predict ovarian hyperstimulation syndrome in women undergoing controlled ovarian hyperstimulation.

Abstract：

OBJECTIVE:To assess the predictive value of endocrine gland-derived vascular endothelial growth factor (EG-VEGF) concentrations in follicular fluid (FF) and serum for ovarian hyperstimulation syndrome (OHSS) in patients undergoing controlled ovarian hyperstimulation. DESIGN:Retrospective, case-control study. SETTING:University hospital, IVF center. PATIENT(S):Seventeen women with OHSS and 61 controls. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):FF and serum EG-VEGF and VEGF concentrations, IVF outcome. RESULT(S):FF and serum EG-VEGF concentrations showed a significant negative correlation with serum E(2) concentration on the day of hCG administration. FF, but not serum, VEGF concentrations also showed a significant negative correlation with serum E(2) concentrations on hCG day. The FF EG-VEGF, FF VEGF, and serum EG-VEFG concentrations were significantly lower in the OHSS group than in the non-OHSS group. There was no significant difference in serum VEGF concentrations. Among FF and serum EG-VEGF and VEGF concentrations, only FF EG-VEGF concentrations were significantly lower in patients with moderate OHSS than in those with mild OHSS. CONCLUSION(S):FF and serum EG-VEGF concentrations may predict OHSS occurrence. Furthermore, FF EG-VEGF concentrations were significantly correlated with OHSS severity; thus, EG-VEGF appears to be more valuable than VEGF for predicting OHSS.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Gao MZ,Zhao XM,Sun ZG,Hong Y,Zhao LW,Zhang HQ

doi

10.1016/j.fertnstert.2010.09.044

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

673-8

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(10)02606-3

journal_volume

95

pub_type

杂志文章

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