Abstract：
OBJECTIVE:To critically examine ovarian reserve testing before assisted reproduction. DESIGN:A PUBMED computer search to identify relevant literature. SETTING:Multiple sites. PATIENT(S):Patients undergoing assisted reproduction. INTERVENTION(S):Testing for ovarian reserve. MAIN OUTCOME MEASURE(S):Assisted reproductive technology (ART) and pregnancy outcomes. RESULT(S):The prevalence of ovarian insufficiency varies significantly for women aged 30-45 years. Generalization or averaging of threshold values across different aged women leads to very poor sensitivity, specificity, and positive predictive value for all tests of ovarian reserve. Because of the changing prevalence of ovarian insufficiency, there is no single, suitable threshold value for any screening test of ovarian reserve. Our analysis supports dividing impaired ovarian reserve into two groups: age-dependent ovarian aging (physiologic) and premature (nonphysiologic) reductions in the oocyte pool. Interpretation of any screening test used requires that age is considered as a variable. To guide clinical interpretation of test results, we suggest using a nomogram of FSH values versus expected delivery rate-per-cycle-start with ART for a given age. CONCLUSION(S):Proper interpretation of screening tests for ovarian insufficiency in couples considering ART is important as the presence of impaired ovarian reserve is associated with a low likelihood of pregnancy. The condition of premature (nonphysiologic) ovarian insufficiency warrants additional research.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Sun W,Stegmann BJ,Henne M,Catherino WH,Segars JHdoi
10.1016/j.fertnstert.2007.10.080subject
Has Abstractpub_date
2008-12-01 00:00:00pages
2196-202issue
6eissn
0015-0282issn
1556-5653pii
S0015-0282(07)03966-0journal_volume
90pub_type
杂志文章,评审abstract：:For sperm DNA assessments to be widespread effective clinical tools, key objectives need to be urgently achieved. These include robust standardized methods, systems for training staff and ongoing quality control; and rigorous examination of the clinical outcomes. We discuss the significance of these objectives and con...
journal_title：Fertility and sterility
pub_type： 社论
doi：10.1016/j.fertnstert.2010.07.1050
更新日期：2010-11-01 00:00:00
abstract：OBJECTIVE:To evaluate whether the presence of kissing ovaries at ultrasound is a marker for endometriosis and whether it correlates with the severity of the disease. DESIGN:Prospective observational study. SETTING:Gynecologic departments of two university hospitals. PATIENT(S):A total of 722 consecutive premenopausa...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.05.094
更新日期：2005-01-01 00:00:00
abstract：OBJECTIVE:To determine the effects of tibolone and continuous combined HRT (ccHRT) on parameters in the clotting cascade. DESIGN:Randomized, double-blind study. SETTING:Hemostasis unit of a university hospital clinic in Germany. PATIENT(S):Sixty healthy postmenopausal women. INTERVENTION(S):Twenty-nine subjects wer...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0015-0282(00)00587-2
更新日期：2000-07-01 00:00:00
abstract：:A surrogate end point (e.g., a laboratory test or image) serves as a proxy for a clinical end point of importance (e.g., fracture, thrombosis, or death). Adoption and use of surrogate end points lacking validation, especially in cardiovascular medicine, have caused thousands of patients' deaths, a serious violation of...
journal_title：Fertility and sterility
pub_type： 社论,评审
doi：10.1016/j.fertnstert.2009.12.054
更新日期：2010-04-01 00:00:00
abstract：:Women with a BRCA mutation have unique concerns about childbearing and future fertility. In a focus group conducted among unaffected carriers, the majority of women held positive attitudes toward preimplantation genetic diagnosis to reduce transmission to future offspring and further identified unmet needs for educati...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.03.064
更新日期：2010-11-01 00:00:00
abstract：:Nitrofurantoin sodium and nitorfurazone, in certain critical concentrations, have the ability to immobilize spermatozoa. In this study, this effect was consisitent with both 5:1, and 10:1 dilutions. Histologic examination of the effects of these drugs as intraoperative vas irrigants revealed no apparent tissue toxicit...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)41168-4
更新日期：1975-06-01 00:00:00
abstract：OBJECTIVE:To determine the relationship between some reproductive variables and infertility caused by tubal obstruction. DESIGN:A retrospective, case-control study. SETTING:A tertiary care university hospital that is a referral center for infertility patients. PARTICIPANTS:Subjects were interviewed between March 199...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：OBJECTIVE:To study the expression of FOXO1 and pSer256-FOXO1 parallel to Akt and pSer473-Akt in leiomyoma compared with adjacent myometrium from human uteri. DESIGN:Prospective study. SETTING:University departments. PATIENT(S):Thirty-eight cyclic and 20 menopausal women who underwent hysterectomy for benign indicati...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2009.07.1670
更新日期：2010-09-01 00:00:00
abstract：OBJECTIVE:To study the association of adrenal and ovarian androgen levels with metabolic parameters in a large cohort of women with polycystic ovary syndrome (PCOS). DESIGN:Cross-sectional study. SETTING:Outpatient clinic of an academic hospital. PATIENT(S):Six hundred twenty-two women with PCOS. INTERVENTION(S):No...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2012.07.1057
更新日期：2012-11-01 00:00:00
abstract：OBJECTIVE:To compare danazol and gestrinone treatment as preoperative endometrial preparation for operative hysteroscopy. DESIGN:Prospective, randomized clinical study. SETTING:University department of gynecological, obstetrical sciences and reproductive medicine. PATIENT(S):One hundred thirty-five patients with end...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2005.09.034
更新日期：2006-04-01 00:00:00
abstract：OBJECTIVE:To assess right-left differences in ultrasonographic markers of ovarian morphology and determine the impact on the diagnosis of polycystic ovarian morphology (PCOM). DESIGN:A cross-sectional study of data collected from 2006 to 2018. SETTING:Academic clinical research centers. PATIENT(S):Women with polycys...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2019.06.016
更新日期：2019-11-01 00:00:00
abstract：OBJECTIVE:To harmonize the collection of nonsurgical clinical and epidemiologic data relevant to endometriosis research, allowing large-scale collaboration. DESIGN:An international collaboration involving 34 clinical/academic centers and three industry collaborators from 16 countries on five continents. SETTING:In 20...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2014.07.1244
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:To compare the clinical outcomes between letrozole and clomiphene citrate (CC) in gonadotropin-combined intrauterine insemination (IUI) cycles. DESIGN:Prospective pilot study. SETTING:One university hospital and two private infertility clinics. PATIENT(S):Ninety-three infertile couples eligible for superov...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.02.070
更新日期：2006-06-01 00:00:00
abstract：OBJECTIVE:To determine the effects of prior gravidity on hormonal parameters, medication regimen, oocyte parameters, fertilization, and clinical pregnancy rates (PRs) in donor and own oocyte cycles. DESIGN:A retrospective study of 64 first-attempt ovum donor cycles and 102 first-attempt IVF and ZIFT cycles using own o...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)58157-6
更新日期：1996-03-01 00:00:00
abstract：OBJECTIVE:To evaluate the heparin-glutathione test (HEGLUT) for the selection of viable sperm for intracytoplasmic sperm injection (ICSI). DESIGN:A prospective study. SETTING:Department of Pediatrics, Obstetrics and Gynecology, University of Valencia and Instituto Valenciano de Infertilidad. PATIENT(S):Semen samples...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(98)00334-3
更新日期：1998-12-01 00:00:00
abstract：OBJECTIVE:To estimate the incidence of endometriosis in an operative cohort of women seeking clinical care and in a matched population cohort to delineate more fully the scope and magnitude of endometriosis in the context of and beyond clinical care. DESIGN:Matched-exposure cohort design. SETTING:Surgical centers in ...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2011.05.087
更新日期：2011-08-01 00:00:00
abstract：OBJECTIVE:To determine the effect of sodium alginate encapsulation of rodent embryos on in vitro embryonic cleavage rates, implantation rates, and livebirth rates, and to find the in vivo degradation time for the capsules. DESIGN:Studies were conducted using both CB6F1 mice and Golden Syrian hamsters. RESULTS:Capsule...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)55814-2
更新日期：1993-03-01 00:00:00
abstract：OBJECTIVE:To examine the emotional, sexual, physical, and quality-of-life (QOL) impact on infertile women awaiting oocyte donation. DESIGN:Cross-sectional cohort study. SETTING:Cancer center and reproductive medicine center. PATIENT(S):Fifty infertile women awaiting oocyte donation, enrolled from October 2006 to Feb...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.10.004
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:To determine, for a woman aged >45 years, whether selected hormonal, health status, and demographic measures are related to the time to final menstrual period (FMP) from a point where 6 weeks separate the shortest and longest cycles experienced to date. DESIGN:Cohort study. SETTING:Volunteers in an academic...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(02)03231-4
更新日期：2002-08-01 00:00:00
abstract：OBJECTIVE:To test the hypothesis that male reproductive tract leukocytes function in the elimination of abnormal spermatozoa from ejaculated semen. DESIGN:Semen specimens with > or = 2 x 10(6) nonspermatozoal cells/mL were examined for leukocytes and for mature sperm with ideal morphology. SETTING:Andrology laborator...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1995-07-01 00:00:00
abstract：:Hormonal profiles were compared in 14 ovulatory women who were treated with two different doses of gonadotropins in successive in vitro fertilization cycles. All patients suffered from mechanical causes of infertility. Serum estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and progesterone...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1988-06-01 00:00:00
abstract：:The effectiveness of Buserelin (Hoechst-Roussel Pharmaceuticals, Inc., Somerville, NJ) (0.2 mg subcutaneously [SC] or 1.2 mg intranasally [IN] per day) and danazol (800 mg per day) in inducing ovarian suppression for the management of endometriosis was compared in a prospective randomized study. During 6 months of tre...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(16)60543-5
更新日期：1989-03-01 00:00:00
abstract：OBJECTIVE:To evaluate the changes of pain symptoms induced by buserelin acetate, a gonadotropin-releasing hormone agonist, in a group of patients with endometriosis. DESIGN:Thirty-five infertile patients with one or more of the following symptoms (dysmenorrhea, pelvic pain, deep dyspareunia, and endometriosis stage I ...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(16)55792-6
更新日期：1993-03-01 00:00:00
abstract：OBJECTIVE:To assess the correlation between in vitro fertilization (IVF) and complications of the third stage of labor. DESIGN:Retrospective cohort of vaginal deliveries from November 2008 to January 2020. Maternal and obstetric outcomes of singleton deliveries were compared between IVF and non-IVF pregnancies. SETTI...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2020.10.004
更新日期：2020-11-30 00:00:00
abstract：OBJECTIVE:To determine the feasibility of asking women undergoing fertility treatment the maximum increased risk of ovarian cancer they would be willing to tolerate in order to take ovulation-induction drugs. DESIGN:A prospective pilot study of women attending fertility clinics over a 2-month period. SETTING:Two tert...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)81481-1
更新日期：1997-07-01 00:00:00
abstract：:The promoter of P receptor isoform B (PR-B) has recently been shown to be hypermethylated in endometriotic tissues, but one question remains as what causes the aberrant methylation. We show that sustained stimulation of an epithelial-like endometriotic cell line with tumor necrosis factor alpha stimulation for 30 days...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.06.008
更新日期：2008-07-01 00:00:00
abstract：:The research published to date does not show a definitive positive impact of acupuncture on IVF success rates. However, researchers seem to lack traditional scientific practices when interpreting the data. ...
journal_title：Fertility and sterility
pub_type： 评论,杂志文章,评审
doi：10.1016/j.fertnstert.2005.10.063
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the feasibility and the efficacy of in vitro maturation (IVM) when immature oocyte collection was performed in the early follicular, late follicular, or luteal phases in women with cancer who require urgent chemotherapy. DESIGN:Retrospective cohort study. SETTING:University teaching hospital. P...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2016.09.041
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVE:To evaluate vaginal bleeding profiles with lower doses of conjugated equine estrogens (CEE) and medroxyprogesterone acetate (MPA) as continuous combined therapy. DESIGN:The Women's Health, Osteoporosis, Progestin, Estrogen (Women's HOPE) study, a randomized, double-blind, placebo-controlled trial. SETTING:S...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0015-0282(01)01792-7
更新日期：2001-06-01 00:00:00
abstract：:Twenty-three patients with otherwise unexplained infertility underwent abdominal myomectomy for the removal of subserous or intramural myomata. None were submucosal in location. Fifteen of these patients (65.2%) conceived. There were 18 term births in 13 patients. All but 1 patient conceived within the first year. The...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)49536-1
更新日期：1986-08-01 00:00:00
