Abstract：
OBJECTIVE:To study the expression of FOXO1 and pSer256-FOXO1 parallel to Akt and pSer473-Akt in leiomyoma compared with adjacent myometrium from human uteri. DESIGN:Prospective study. SETTING:University departments. PATIENT(S):Thirty-eight cyclic and 20 menopausal women who underwent hysterectomy for benign indications. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Western blot analyses were used for evaluation in leiomyoma and adjacent myometrium of Akt and pSer473-Akt, 14-3-3 gamma proteins and expression and subcellular distribution of FOXO1 and pSer256-FOXO1 during the menstrual cycle and at menopause. RESULT(S):The present study demonstrates the expression of FOXO1 and pSer256-FOXO1 at the tissue level in the human uterus leiomyoma and adjacent myometrium. The level of phosphorylated FOXO1 in leiomyoma was higher than in matched myometrium. The pSer256-FOXO1 in leiomyoma during menstrual phases was located mostly in the nuclear fraction comparison to that of the myometrium. The reason for this difference is presumably the simultaneously detected lower level of 14-3-3 protein. CONCLUSION(S):Abundant level of the phosphorylated FOXO1, its impaired nucleocytoplasmic shuttling, and the lowered expression of 14-3-3 protein in leiomyoma induces a shift in the cellular machinery toward a prosurvival execution program and thus presents a potential therapeutic target for treatment of leiomyoma.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Kovács KA,Lengyel F,Wilhelm F,Vértes Z,Sumegi B,Vértes Mdoi
10.1016/j.fertnstert.2009.07.1670subject
Has Abstractpub_date
2010-09-01 00:00:00pages
1491-1495issue
4eissn
0015-0282issn
1556-5653pii
S0015-0282(09)03461-Xjournal_volume
94pub_type
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doi：10.1016/s0015-0282(99)00224-1
更新日期：1999-08-01 00:00:00
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更新日期：2010-06-01 00:00:00
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更新日期：2003-09-01 00:00:00
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更新日期：2009-02-01 00:00:00
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pub_type： 杂志文章,meta分析
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更新日期：2018-10-01 00:00:00
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更新日期：2017-07-01 00:00:00
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更新日期：2003-04-01 00:00:00
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doi：10.1016/j.fertnstert.2008.10.046
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVE:To evaluate the influence of somatostatin analogue (octreotide) in the function of hypothalamic-pituitary-adrenal (HPA) axis in women with polycystic ovary syndrome (PCOS). SETTING:Women referred to the Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore. PATIENT(S):Twelve PCOS wom...
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doi：10.1016/s0015-0282(97)81852-3
更新日期：1997-01-01 00:00:00
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doi：10.1016/s0015-0282(16)53169-0
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doi：10.1016/j.fertnstert.2007.01.050
更新日期：2007-12-01 00:00:00
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pub_type： 评论,杂志文章
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更新日期：2012-11-01 00:00:00
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更新日期：2015-02-01 00:00:00
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更新日期：2006-11-01 00:00:00
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更新日期：2014-08-01 00:00:00
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更新日期：2016-02-01 00:00:00
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更新日期：2005-12-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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abstract：INTRODUCTION:Polycystic ovary syndrome (PCOS) is a highly prevalent disorder among postmenarcheal premenopausal women, accounting for much of anovulatory infertility, and it is associated with several comorbidities. The natural history of PCOS, as well as hypotheses regarding its etiology, facilitates employment of the...
journal_title：Fertility and sterility
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doi：10.1016/j.fertnstert.2005.09.066
更新日期：2006-07-01 00:00:00
