Oocyte retrieval timing based on spontaneous luteinizing hormone surge during natural cycle in vitro fertilization treatment.


OBJECTIVE:To determine the efficiency of oocyte retrieval (OR) timing based on the occurrence of spontaneous LH surge during natural cycle IVF (ncIVF) treatment. DESIGN:Retrospective cohort study. The cohort was divided into five subgroups according to the presumed stage of spontaneous LH surge on scheduling day (1A: before onset; 1B: surge start; 2: ascending slope; 3: peak; and 4: descending slope). SETTING:Private infertility clinic. PATIENT(S):Three hundred sixty-five infertile patients who underwent 1,138 ncIVF treatment cycles during 2008-2011. INTERVENTION(S):Drug-free ncIVF treatment. MAIN OUTCOME MEASURE(S):Rate of successfully retrieved, fertilized oocytes, cleaved embryos, and live births per scheduled oocyte retrieval. RESULT(S):In 61% of the cycles OR was scheduled before or just at the start of the LH surge (groups 1A-1B), whereas in the remaining cases it was scheduled after the surge had already started (groups 2-4). The proportion of cycles with successfully recovered (range, 71%-86%), inseminated (range, 61%-78%), fertilized oocytes (range, 47%-68%), cleaved embryos (range, 45%-66%), and live births (range, 4.1%-9.2%) was not significantly different among subgroups. CONCLUSION(S):In ncIVF treatment OR timing based on the occurrence of spontaneous LH surge is feasible, yielding acceptable oocyte recovery, fertilization, and embryo cleavage rates. This strategy combined with a rapid and low-risk OR procedure permits the management of a large ncIVF program on a 7-days-per-week basis within working hours.


Fertil Steril


Fertility and sterility


Bodri D,Kawachiya S,Kondo M,Kato R,Matsumoto T




Has Abstract


2014-04-01 00:00:00














  • Fertility, pregnancy, and medical management of Turner syndrome in the reproductive years.

    abstract::Turner syndrome results in infertility in most cases. Fertility preservation through the cryopreservation of oocytes or ovarian tissue may be an option for some girls with Turner syndrome. Oocyte donation results in high pregnancy rates (PR). Those women who plan to pursue pregnancy need comprehensive screening and co...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Karnis MF

    更新日期:2012-10-01 00:00:00

  • Comparison of techniques for the selection of bacteria-free sperm preparations.

    abstract::The authors compared the three most commonly used sperm preparation techniques--swim-up, fall-down, and Percoll gradient--for their ability to recover highly motile sperm and minimize bacterial contamination. Eleven human semen samples collected by masturbation were used and run in parallel with the three methods. A s...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Sun LS,Gastaldi C,Peterson EM,de la Maza LM,Stone SC

    更新日期:1987-10-01 00:00:00

  • A simplified method for freezing and storage of human semen.

    abstract::The use of 10-cm-long plastic tuberculin syringes for freezing and storage of human semen is introduced. This new method reduces the number of prefreezing and postthawing manipulations to a minimum. Postthawing motility, penetration of spermatozoa into cervical mucus, and results of the hamster ovum test were similar ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kremer J,Dijkhuis JR,Jager S

    更新日期:1987-05-01 00:00:00

  • Differences in ovarian stimulation in human menopausal gonadotropin treated woman may be related to follicle-stimulating hormone accumulation.

    abstract::Two groups of normal ovulatory women who displayed either a marked (high responders; HR) or a more subtle (low responders; LR) ovarian response to a fixed dose of human menopausal gonadotropins (hMG) were evaluated for differences in blood levels of hormones. Serum follicle-stimulating hormone (FSH) levels doubled dur...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ben-Rafael Z,Strauss JF 3rd,Mastroianni L Jr,Flickinger GL

    更新日期:1986-10-01 00:00:00

  • Repeated in vitro fertilization cycle attempts in patients undergoing controlled ovarian hyperstimulation with use of gonadotropin-releasing hormone antagonists.

    abstract::To examine pregnancy rate in patients undergoing controlled ovarian hyperstimulation (COH) with use of multidose GnRH antagonists in multiple repeated IVF cycle attempts, we conducted a survey in 785 consecutive IVF cycles in our unit. Although pregnancy rate significantly decreased beyond the second IVF cycle attempt...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Rabinson J,Ashkenazi J,Homburg R,Meltcer S,Anteby EY,Orvieto R

    更新日期:2009-04-01 00:00:00

  • Immunolocalization of a sperm membrane protein in human male reproductive organs.

    abstract::A monoclonal antibody that induces agglutination of human sperm was used to localize the interacting antigen in various tissues by indirect immunofluorescence. The antibody localized to the immature sperm and Sertoli cells of the seminiferous tubules, simple cuboidal epithelial cells of the rete testis, and the column...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Yan YC,Mitsudo SM,Wang LF,Koide SS

    更新日期:1984-10-01 00:00:00

  • Preconception folic acid treatment affects the microenvironment of the maturing oocyte in humans.

    abstract:OBJECTIVE:To investigate the influence of folic acid supplementation on the follicular fluid concentrations of folate and total homocysteine and their relationship to the diameter of the follicle. DESIGN:Observational study. SETTING:Tertiary referral fertility clinic at the Erasmus MC, University Medical Center, Rott...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Boxmeer JC,Brouns RM,Lindemans J,Steegers EA,Martini E,Macklon NS,Steegers-Theunissen RP

    更新日期:2008-06-01 00:00:00

  • A mutation c.C2812T in the androgen receptor gene resulting in Pro817Leu substitution may affect dimerization of the androgen receptor and result in androgen insensitivity syndrome.

    abstract:OBJECTIVE:To conduct clinical, genetic, and molecular diagnostics of two sisters with typical symptoms of complete androgen insensitivity syndrome. DESIGN:Case report. SETTING:Research laboratory at a university of medical science. PATIENT(S):Two patients with 46,XY karyotype and a female phenotype were diagnosed be...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Turek-Plewa J,Eckersdorf-Mastalerz A,Kaluzewski B,Helszer Z,Trzeciak WH

    更新日期:2006-06-01 00:00:00

  • Determination of Poly (ADP-ribose) polymerase (PARP) homologues in human ejaculated sperm and its correlation with sperm maturation.

    abstract:OBJECTIVES:To investigate the presence of Poly (ADP-ribose) polymerase (PARP) and evaluate its function in ejaculated spermatozoa. DESIGN:Experimental study. SETTING:Reproductive Research Center. PATIENT(S):Semen specimens from 18 healthy donors and 12 infertile males. INTERVENTION(S):Ejaculated spermatozoa were su...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Jha R,Agarwal A,Mahfouz R,Paasch U,Grunewald S,Sabanegh E,Yadav SP,Sharma R

    更新日期:2009-03-01 00:00:00

  • Association of human leukocyte antigen-G 14 bp polymorphism with recurrent pregnancy loss in European countries: a meta-analysis of literature studies.

    abstract:OBJECTIVE:To study the controversial association between human leukocyte antigen-G (HLA-G) 14 bp polymorphism and recurrent pregnancy loss (RPL). We performed a meta-analysis of studies in the literature that enrolled only women of European countries who experienced RPL spontaneously or after undergoing IVF. DESIGN:Sy...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,meta分析


    authors: Monti M,Lupoli R,Sosa Fernandez LM,Cirillo F,Di Minno MND

    更新日期:2019-09-01 00:00:00

  • Introduction: Continuing story of premature progesterone elevation.

    abstract::Since the late 1980s premature progesterone elevation has repeatedly caught the attention of investigators, not only for its importance, but also because studies have shown differing results and conclusions, constituting an unexplainable sequence of doubts and uncertainties. This issue's Views and Reviews section seek...

    journal_title:Fertility and sterility



    authors: Fanchin R

    更新日期:2018-04-01 00:00:00

  • Effects of competition among fertility centers on pregnancy and high-order multiple gestation rates.

    abstract:OBJECTIVE:To measure the effect of competition among fertility centers on pregnancy and high-order multiple (HOM) gestation rates after IVF. DESIGN:Retrospective cohort study. SETTING:Four hundred eight fertility clinics registered with the Society for Assisted Reproductive Technology as providing IVF services in 200...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Steiner AZ,Paulson RJ,Hartmann KE

    更新日期:2005-05-01 00:00:00

  • Y-chromosome microdeletion and phenotype in cytogenetically normal men with idiopathic azoospermia.

    abstract:OBJECTIVE:To determine the prevalence of microdeletions of the long arm of chromosome Y within the AZFa, AZFb, and AZFc subregions in patients with idiopathic azoospermia, and then correlate the microdeletions with clinical phenotypes to determine the most important subregion for screening. DESIGN:Controlled clinical ...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Fujisawa M,Shirakawa T,Kanzaki M,Okada H,Arakawa S,Kamidono S

    更新日期:2001-09-01 00:00:00

  • Doxazosin blockade of alpha 1-adrenergic receptors increases rat serum progesterone levels: a putative role of ovarian angiotensin III in steroidogenesis.

    abstract:OBJECTIVE:To analyze the role of the local renin-angiotensin system (RAS) in the female reproductive system to modulate ovarian steroidogenesis and its relationship with alpha(1)adrenergic receptors. DESIGN:Observational study. SETTING:University laboratory. ANIMAL(S):Adult female Wistar rats treated with doxazosin ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: de la Chica-Rodríguez S,Cortés-Denia P,Ramírez-Expósito MJ,de Saavedra JM,Sánchez-Agesta R,Pérez Mdel C,Martínez-Martos JM

    更新日期:2007-10-01 00:00:00

  • Regulated upon activation, normal T cell expressed and secreted (RANTES) and monocyte chemotactic protein 1 in follicular fluid accumulate differentially in patients with and without endometriosis undergoing in vitro fertilization.

    abstract:OBJECTIVE:To compare the amount of regulated upon activation, normal T cell expressed and secreted (RANTES) and monocyte chemotactic protein 1 (MCP-1) in follicular fluid (FF) of patients with and without endometriosis and to determine their oocyte fertilization and pregnancy rates. DESIGN:Case-control study. SETTING...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Xu H,Schultze-Mosgau A,Agic A,Diedrich K,Taylor RN,Hornung D

    更新日期:2006-12-01 00:00:00

  • OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome.

    abstract::To show that in the dysgenetic gonads of 104 Turner syndrome patients no significant difference was found regarding the expression of the genes DAX1, FOG2, GATA4, OCT4, SF1, SRY, TSPY, WT1, and STRA8 compared with controls, except for genes OCT4, SRY, and TSPY in both gonads of a patient whose chromosomal constitution...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Bianco B,Oliveira KC,Guedes AD,Barbosa CP,Lipay MV,Verreschi IT

    更新日期:2010-11-01 00:00:00

  • Preservation techniques for human semen.

    abstract::Sperm banking with the relatively simple and economical biologic freezer (Linde BF-5; Union Carbide Corporation, Linde Division, New York, N.Y.) was compared with controlled-rate freezer (Linde CRF-1; Union Carbide), using different freezing rates and cryoprotective media. The results were assessed by comparing prefre...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Thachil JV,Jewett MA

    更新日期:1981-05-01 00:00:00

  • Influence of progesterone on endometrial nitric oxide synthase expression.

    abstract:OBJECTIVE:To determine the effect of P on nitric oxide synthase (NOS) expression in human endometrial epithelial cells. DESIGN:Laboratory-based study. SETTING:University-based research institute. PATIENT(S):None. INTERVENTION(S):The effect of P on the expression of NOS protein isoforms was examined in an in vitro p...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Khorram O,Han G

    更新日期:2009-05-01 00:00:00

  • Cytogenetic investigations on human oocytes and early human embryonic stages.

    abstract::The chromosome analysis of undivided oocytes and polyploid embryos within a human in vitro fertilization and embryo replacement program offers a unique opportunity to develop correlations between a successful or unsuccessful fertilization and the maturity of the oocytes or the quality of the sperm. Furthermore, it pro...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Michelmann HW,Mettler L

    更新日期:1985-02-01 00:00:00

  • The benefit of human chorionic gonadotropin supplementation throughout the secretory phase of frozen-thawed embryo transfer cycles.

    abstract:OBJECTIVE:To assess whether supplementation with hCG throughout the secretory phase of hormonally modulated cycles of frozen-thawed embryos might positively affect the outcome of such cycles. DESIGN:Prospective, randomized controlled trial. SETTING:University teaching hospital. PATIENT(S):Patients undergoing frozen-...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Ben-Meir A,Aboo-Dia M,Revel A,Eizenman E,Laufer N,Simon A

    更新日期:2010-02-01 00:00:00

  • Liver function tests in women using intravaginal spermicide nonoxynol-9.

    abstract::The effects of intravaginal application of nonoxynol-9 (N-9) on hematological parameters, routine liver function biochemistry (bilirubin, serum bile acid, SGOT, SGPT, GGT, alkaline phosphatase), and serum lipids (cholesterol and triglyceride) were evaluated in 10 normal women who received 150 mg N-9 daily for 14 conse...

    journal_title:Fertility and sterility

    pub_type: 信件


    authors: Chvapil M,Droegemueller W,Earnest DL

    更新日期:1982-02-01 00:00:00

  • Choice of treatment for women with polycystic ovary syndrome.

    abstract::Polycystic ovary syndrome presents with many different symptoms and signs, for which different therapies are indicated. However, for the majority of women, the metabolic disorder requires diligence in management, regardless of the presenting complaint. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lobo RA

    更新日期:2006-07-01 00:00:00

  • Effect of indomethacin on the vascular architecture of preovulatory ovine follicles: possible implication in the luteinized unruptured follicle syndrome.

    abstract::Ovarian follicles sometimes fail to rupture and accumulate large quantities of fluid, yet undergo luteinization and form a steroidogenically competent luteal structure, the luteinized unruptured follicle syndrome. This condition can be mimicked in mammals by administration of indomethacin, an inhibitor of biosynthesis...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Murdoch WJ,Cavender JL

    更新日期:1989-01-01 00:00:00

  • Von Willebrand factor expression in endometrial endothelial cells in women with menorrhagia.

    abstract::This prospective study assessed von Willebrand factor (VWF) expression in the endometrium using immunohistochemical staining in women with menorrhagia with or without von Willebrand disease (VWD) compared with a control group of women with normal menstrual loss. Endometrial VWF expression is significantly lower in wom...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Agarwal U,El Sheikh S,Kulkarni A,Baff D,Kadir RA

    更新日期:2010-11-01 00:00:00

  • Placental protein 14 levels in uterine flushing and plasma of women with unexplained infertility.

    abstract:OBJECTIVES:To measure concentrations of placental protein 14 (PP14) in uterine flushings and plasma samples obtained from patients with unexplained infertility and to compare the results of those of normal fertile women. DESIGN:Prospective study. SETTING:Infertility and gynaecology outpatient clinics at the Jessop Ho...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Mackenna A,Li TC,Dalton C,Bolton A,Cooke I

    更新日期:1993-03-01 00:00:00

  • Preconceptional antithyroid peroxidase antibodies, but not thyroid-stimulating hormone, are associated with decreased live birth rates in infertile women.

    abstract:OBJECTIVE:To study whether preconceptual thyroid-stimulating hormone (TSH) and antithyroid peroxidase (TPO) antibodies are associated with poor reproductive outcomes in infertile women. DESIGN:Secondary analysis of data from two multicenter, randomized, controlled trials conducted by the Reproductive Medicine Network ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Seungdamrong A,Steiner AZ,Gracia CR,Legro RS,Diamond MP,Coutifaris C,Schlaff WD,Casson P,Christman GM,Robinson RD,Huang H,Alvero R,Hansen KR,Jin S,Eisenberg E,Zhang H,Santoro N,Eunice Kennedy Shriver National Institute

    更新日期:2017-10-25 00:00:00

  • Occupation and the follow-up of infertile couples.

    abstract:OBJECTIVE:To evaluate the influence of socioeconomic factors on the outcomes of infertility, including pregnancy, adoption, resolution, and loss to follow-up. DESIGN:Prospective observational study. SETTING:Infertility clinics in 11 teaching hospitals. PATIENTS:Newly registered couples with infertility of > 1 year. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Collins JA,Burrows EA,Willan AR

    更新日期:1993-09-01 00:00:00

  • Fertility in a female with mosaic trisomy 8.

    abstract:OBJECTIVE:To describe the first term pregnancy in a patient with the characteristic features of trisomy 8 mosaicism. DESIGN:Case report. SETTING:University department. PATIENT(S):The 23-year-old proband had a history of cleft palate, mixed bilateral hearing loss, short stature, and developmental delay. She had dysmo...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Rauen KA,Golabi M,Cotter PD

    更新日期:2003-01-01 00:00:00

  • The use of the argon laser in the treatment of experimental endometriosis.

    abstract::The argon laser offers several theoretical advantages over excision, electrocautery, or CO2 laser therapy for the treatment of peritoneal implants of endometriosis. Therefore, a study of the feasibility of the argon laser for the treatment of endometriosis was performed using five virgin New Zealand White rabbits. Fol...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Keye WR Jr,Matson GA,Dixon J

    更新日期:1983-01-01 00:00:00

  • Peritoneal fluid of patients with endometriosis promotes proliferation of endometrial stromal cells and induces COX-2 expression.

    abstract::Cell proliferation of endometrial stromal cells treated with peritoneal fluid of women (aged 25 to 43 years) with endometriosis (n = 12) statistically significantly increased compared with the control treatment (peritoneal fluid of women without endometriosis, n = 8). Also, COX-2 gene expression and prostaglandin E(2)...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Liu Y,Hu J,Shen W,Wang J,Chen C,Han J,Zai D,Cai Z,Yu C

    更新日期:2011-04-01 00:00:00