Abstract:
OBJECTIVE:To investigate relationships between cumulus-oocyte complex (COC) morphology, protein patterns of cumulus-corona (CC) cell-conditioned media, and pregnancy outcome in IVF-ET cycles. DESIGN:Retrospective study. SETTING:Private university IVF center. PATIENT(S):One hundred twenty infertile women who underwent IVF-ET procedures. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):COC grading, analysis of CC cell morphology and conditioned media, and pregnancy rate (PR). RESULT(S):After IVF and embryo transfer, cultured CC cells were classified as high (HA) or low (LA) on the basis of their adhesive properties. Neither adhesion activity nor fertilization rates and embryo quality were correlated with COC grading. PR in cycles with HA cells was 38%, but 14% of cycles showing LA activity also had positive outcome. To find more meaningful parameters of CC cells useful to predict fertilization and pregnancy, the electrophoretic protein patterns of media conditioned by HA or LA cells were studied. Retrospective analysis showed that all cycles in which replaced embryos were associated with the presence of a 31-kD band in conditioned media failed implantation, whereas 83% of cycles lacking this band resulted in positive, ongoing pregnancy. CONCLUSION(S):Pregnancy prediction cannot rely simply on CC cell morphological analysis. Screening of conditioned media may provide more reliable parameters.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Cecconi S,Rossi G,Gualtieri R,Talevi Rdoi
10.1016/s0015-0282(01)01754-xkeywords:
subject
Has Abstractpub_date
2001-05-01 00:00:00pages
966-72issue
5eissn
0015-0282issn
1556-5653pii
S0015-0282(01)01754-Xjournal_volume
75pub_type
杂志文章abstract:OBJECTIVE:To summarize the available published randomized controlled trial data regarding timing of P supplementation during the luteal phase of patients undergoing assisted reproductive technology (ART). DESIGN:A systematic review. SETTING:Not applicable. PATIENT(S):Undergoing IVF. INTERVENTION(S):Different starti...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2014.12.125
更新日期:2015-04-01 00:00:00
abstract::Semen analyses were performed and serum and seminal plasma prolactin (PRL) concentrations were determined in 165 samples from 120 men seen with their wives because of infertility. The mean (+/- standard deviation) serum and seminal plasma PRL concentrations were 6.5 +/- 3.3 and 7.5 +/- 3.1 ng/ml, respectively. The mea...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)59664-2
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:To describe the case of a Japanese woman with combined 17alpha-hydroxylase/17,20-lyase deficiency (congenital adrenal hyperplasia type V) and to discuss possible therapeutic procedures in such patients. DESIGN:Case report. SETTING:University hospital. PATIENT(S):A 26-year-old woman with secondary amenorrhe...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(00)00500-8
更新日期:2000-06-01 00:00:00
abstract::Human testes, removed in treating patients for prostatic carcinoma, were used. Tissues were homogenized and incubated in vitro with labeled progesterone and 2 different antiovulatories, lynestrenol (17alpha-ethin yl-17beta-hydroxy-estr-4-one) and MK 665 (17alpha-chloroethinyl-19-nor-4 ,9(10)-androstadiene-17beta-ol-...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)36309-9
更新日期:1967-05-01 00:00:00
abstract:OBJECTIVES:To investigate the presence of Poly (ADP-ribose) polymerase (PARP) and evaluate its function in ejaculated spermatozoa. DESIGN:Experimental study. SETTING:Reproductive Research Center. PATIENT(S):Semen specimens from 18 healthy donors and 12 infertile males. INTERVENTION(S):Ejaculated spermatozoa were su...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.12.079
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:To assign cutoff values for human chorionic gonadotropin (beta-hCG) in pretreatment and after one methotrexate (MTX) cycle and determine its correspondence to the number of MTX cycles in successfully treated ectopic pregnancy. DESIGN:Retrospective study. SETTING:Polish university hospital. PATIENT(S):68 wo...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.07.1775
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:To test by genomic analysis whether empty follicle syndrome (EFS) in a family with two affected sisters has a genetic basis. DESIGN:Whole-exome sequencing in the context of clinical genetics. SETTING:University hospital. PATIENT(S):Two women (36 and 32 years old at the time of the study) with EFS. INTERVE...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.05.057
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To investigate the expression pattern of proinflammatory, anti-inflammatory, and angiogenic cytokines and their effect on various mediators of endometrial receptivity in women with idiopathic recurrent spontaneous miscarriage (IRSM). DESIGN:A prospective study. SETTING:Tertiary care hospital and reproductiv...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.08.034
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To assess the efficiency of the addition of pentoxifylline to spermatozoa for in vitro fertilization (IVF) in cases with previous fertilization failure. DESIGN:After retrieval, oocytes were divided at random and inseminated with spermatozoa prepared with or without pentoxifylline. SETTING:In vitro fertiliza...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0015-0282(16)55641-6
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:To determine if ultrastructural tissue trauma occurs in the junctional zone in uteri in adenomyosis. DESIGN:A case-control experimental study. SETTING:Endometriosis research center. PATIENT(S):Twelve uteri with adenomyosis, and 9 uteri without adenomyosis, were gained during laparoscopy-assisted vaginal hy...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.09.002
更新日期:2015-12-01 00:00:00
abstract::The hyperandrogenic-insulin-resistant acanthosis nigricans syndrome affects between 2% and 5% of hirsute women and is characterized by INS resistance, elevated INS levels, acanthosis nigricans, and androgen excess. These patients' response to therapy is unclear, although long-acting GnRH-a suppression has been propose...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract:OBJECTIVE:To assess the association between recent cigarette smoking (CS) in female and male partners and assisted reproduction technology (ART) outcomes. DESIGN:Cohort prospective study. SETTING:University ART program in Chile. PATIENT(S):One hundred sixty-six couples seeking pregnancy through ART. INTERVENTION(S)...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.09.073
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To investigate the impact of body weight (BW) and insulin levels on gonadotropin and androgen levels in women with the polycystic ovarian syndrome (PCOS). DESIGN:Comparative study of endocrinologic parameters in PCOS women. SETTING:University Hospital Reproductive Endocrinology Unit. PATIENTS:Thirty obese ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55249-2
更新日期:1992-09-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between sperm chromatin defects, evaluated by the flow cytometric (FCM) sperm chromatin structure assay (SCSA), and the probability of a pregnancy in a menstrual cycle (fecundability). DESIGN:Follow-up study. SETTING:The Section of Toxicology and Biomedical Sciences, ENEA Casacci...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(99)00462-8
更新日期:2000-01-01 00:00:00
abstract::We describe a cotyledonoid dissecting leiomyoma in a 33-year-old nulliparous woman treated by laparoscopy. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.08.131
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of melatonin both on the ovaries of pinealectomized female rats through histomorphometric analysis and on steroid receptors, proliferating cell nuclear antigen (PCNA), and vascular endothelial growth factor (VEGF) expression. DESIGN:Experimental study. SETTING:Federal University of Sã...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.04.042
更新日期:2011-03-15 00:00:00
abstract:OBJECTIVE:To determine the incidence of ovarian hyperstimulation syndrome (OHSS) in a large series of GnRH antagonist-stimulated cycles and to assess the predictive value of E2 and the number of follicles on the day of hCG administration. DESIGN:Prospective cohort study of women undergoing IVF treatment with a GnRH an...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/j.fertnstert.2005.07.1292
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:To compare sperm morphology of electrostimulated ejaculates of spinal cord-injured (SCI) men with that of manual ejaculates of an able-bodied population. DESIGN:Retrospective study. PATIENTS:Spinal cord-injured men (n = 21) participating in a reproductive rehabilitation program and able-bodied men (n = 163)...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)57561-x
更新日期:1995-05-01 00:00:00
abstract:OBJECTIVE:To describe the prevalence of antiphospholipid antibodies to both anionic and zwitterionic phospholipids in women with early recurrent pregnancy losses (RPLs). DESIGN:Retrospective data analysis. SETTING:Tokai University Hospital, Kanagawa, Japan. PATIENT(S):One hundred thirty-nine patients with unexplaine...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(99)00119-3
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:To investigate the possible role of phthalate, a ubiquitous chemical used in consumer products, in the pathogenesis of uterine leiomyoma. DESIGN:Experimental and prospective case-control study using human samples. SETTING:University hospital. PATIENT(S):Fifty-three women with histologic evidence of uterine...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2017.01.015
更新日期:2017-04-01 00:00:00
abstract::We present a case of combined intrauterine and cornual (interstitial) pregnancy after IVF-ET, with survival of the infant after the cornual pregnancy. The diagnosis of this rare phenomenon is difficult; a high index of suspicion and frequently ultrasound monitoring may enable early diagnosis in other forms of heteroto...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53473-6
更新日期:1990-04-01 00:00:00
abstract:OBJECTIVE:To describe a novel mutation in the fumarate hydratase (FH) gene in a family with atypical uterine leiomyomas. DESIGN:Case report and review of the literature. SETTING:Academic community hospital. PATIENT(S):Three sisters who presented as nulligravidas aged 27-30 years with large atypical uterine leiomyoma...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.09.034
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To determine if mutations in NELF, a gene isolated from migratory GnRH neurons, cause normosmic idiopathic hypogonadotropic hypogonadism (IHH) and Kallmann syndrome (KS). DESIGN:Molecular analysis correlated with phenotype. SETTING:Academic medical center. PATIENT(S):A total of 168 IHH/KS patients as well ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.01.010
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To determine whether the stripping technique by laparoscopy is a tissue-sparing procedure. DESIGN:Prospective study. SETTING:University hospital. PATIENT(S):Forty-two women, 21 to 35 years of age, who had a unilateral ovarian cyst (26 endometriomas, 7 serous, 6 dermoid, and 3 mucinous cysts). INTERVENTION...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(01)03203-4
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:To manipulate the luteal endometrial progression by the use of antiprogestins. DESIGN:Prospective controlled clinical trial. SETTING:The IVF program of the University of Southern California School of Medicine, Los Angeles, California. PATIENT(S):Thirteen oocyte donors and 20 oocyte recipients. INTERVENTIO...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/S0015-0282(97)81918-8
更新日期:1997-02-01 00:00:00
abstract:OBJECTIVE:To examine the effect of a gonadotropin-releasing hormone agonist (GnRH-a), leuprolide acetate (LA), on human chorionic gonadotropin/luteinizing hormone (LH) receptors content and progesterone (P) and estradiol (E2) production in cultured granulosa or luteal cells. DESIGN:Prospective. SETTING:Private Fertil...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
abstract:OBJECTIVE:To review the impacts of obesity on women's reproductive health and fertility. DESIGN:Literature review. SETTING:Academic medical center. PATIENT(S):Forty articles are referenced. The number of patients evaluated in each of the studies varies from 33 to 213,208. INTERVENTION(S):Articles were identified fr...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.02.141
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that IVF-ET pregnancy rates (PRs) for patients with tubal factor infertility are decreased in patients with hydrosalpinges and that surgical correction reverses this effect. DESIGN:Retrospective chart review. SETTING:Private practice IVF-ET program. PATIENT(S):Patients (n = 160) unde...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/s0015-0282(97)00447-0
更新日期:1998-01-01 00:00:00
abstract::The importance of the operating microscope in rabbit tubal anastomosis was assessed by operating on 36 rabbits, half with the aid of the operating microscope and half with the aid of low-magnification loupes. The surgeons' operating comfort and sense of assuredness that the anastomoses were being done properly were in...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)47303-6
更新日期:1983-09-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between MMPI-2 scores and oocyte donation outcome. DESIGN:Descriptive chart review. SETTING:Two oocyte donation programs. SUBJECT(S):Five hundred anonymous oocyte donor applicants. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Demographics, MMPI-2 scores and donation outcome. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.08.064
更新日期:2010-10-01 00:00:00