Frequency of premature menopause in women who carry a BRCA1 or BRCA2 mutation.

Abstract:

OBJECTIVE:To evaluate the impact of carrying a BRCA1 or BRCA2 mutation on the probability of experiencing premature natural menopause. DESIGN:Observational study. SETTING:Patients in an academic research environment. PATIENT(S):Women who carry a BRCA1 or BRCA2 mutation (case subjects) and women who do not carry a mutation (control subjects). INTERVENTION(S):Survey about reproductive history administered on study entry and every 2 years thereafter. MAIN OUTCOME MEASURE(S):The impact of carrying a BRCA mutation on age at menopause and other factors, including parity, age at first birth, age at last birth, and self-reported fertility. RESULT(S):A total of 908 matched pairs were identified. The mean age at natural menopause was 48.8 years for BRCA1 carriers, 49.2 years for BRCA2 carriers, and 50.3 years for control subjects. Women who carried a BRCA mutation had parity similar to noncarriers and were as likely as noncarriers to have a child after age 35 years. Similar proportions reported a history of fertility problems (12.5% vs. 13.7%) and use of fertility medication (6.0% vs. 7.0%). CONCLUSION(S):Women who carry a BRCA mutation experience menopause earlier, on average, than women who do not have a mutation, but the difference is small and does not appear to affect fertility.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Finch A,Valentini A,Greenblatt E,Lynch HT,Ghadirian P,Armel S,Neuhausen SL,Kim-Sing C,Tung N,Karlan B,Foulkes WD,Sun P,Narod S,Hereditary Breast Cancer Study Group.

doi

10.1016/j.fertnstert.2013.01.109

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

1724-8

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(13)00165-9

journal_volume

99

pub_type

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