Gonadotropin-releasing hormone agonist trigger in oocyte donors co-treated with a gonadotropin-releasing hormone antagonist: a dose-finding study.


OBJECTIVE:To determine the optimal GnRH agonist dose for triggering of oocyte maturation in oocyte donors. DESIGN:Single-center, randomized, parallel, investigator-blinded trial. SETTING:IVFMD, My Duc Hospital, Ho Chi Minh City, Vietnam. PATIENT(S):One hundred sixty-five oocyte donors (aged 18-35 years, body mass index [BMI] <28 kg/m(2), antimüllerian hormone level >1.25 ng/mL, and antral follicle count ≥6). INTERVENTION(S):Ovulation trigger with 0.2, 0.3, or 0.4 mg triptorelin in a GnRH antagonist cycle. MAIN OUTCOME MEASURE(S):The primary end point was number of metaphase II oocytes. Secondary end points were fertilization and cleavage rates, number of embryos and top-quality embryos, steroid levels, ovarian volume, and ongoing pregnancy rate (PR) in recipients. RESULT(S):There were no significant differences between the triptorelin 0.2, 0.3, and 0.4 mg trigger groups with respect to number of metaphase II oocytes (16.0 ± 8.5, 15.9 ± 7.8, and 14.7 ± 8.4, respectively), embryos (13.2 ± 7.8, 11.7 ± 6.9, 11.8 ± 7.0), and number of top-quality embryos (3.8 ± 2.9, 3.6 ± 3.0, 4.1 ± 3.0). Luteinizing hormone levels at 24 hours and 36 hours after trigger was significantly higher with triptorelin 0.4 mg versus 0.2 mg and 0.3 mg (9.8 ± 7.1 IU/L vs. 7.3 ± 4.1 IU/L and 7.2 ± 3.7 IU/L, respectively; 4.6 ± 3.2 IU/L vs. 3.2 ± 2.3 IU/L and 3.3 ± 2.1 IU/L, respectively. Progesterone level at oocyte pick-up +6 days was significantly higher in the 0.4-mg group (2.2 ± 3.7 ng/ml) versus 0.2 mg (1.1 ± 1.0 ng/ml) and 0.3 mg (1.2 ± 1.6 ng/ml). One patient developed early-onset severe ovarian hyperstimulation syndrome (OHSS). CONCLUSION(S):No significant differences between triptorelin doses of 0.2, 0.3, and 0.4 mg used for ovulation trigger in oocyte donors were seen with regard to the number of mature oocytes and top-quality embryos. CLINICAL TRIAL REGISTRATION NUMBER:NCT02208986.


Fertil Steril


Fertility and sterility


Vuong TN,Ho MT,Ha TD,Phung HT,Huynh GB,Humaidan P




Has Abstract


2016-02-01 00:00:00














  • Embryo transfer using the SureView catheter-beacon in the womb.

    abstract:OBJECTIVE:To compare the performance of the SureView catheter, a new ultrasonic embryo transfer (ET), with the classic Wallace catheter during ultrasound-guided ET. DESIGN:Prospective, randomized study. SETTING:Private, academically affiliated clinic. PATIENT(S):175 patients undergoing donor egg in vitro fertilizati...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Allahbadia GN,Kadam K,Gandhi G,Arora S,Valliappan JB,Joshi A,Allahbadia S,Wolman I

    更新日期:2010-02-01 00:00:00

  • Prevalence, consequence, and significance of reverse cleavage by human embryos viewed with the use of the Embryoscope time-lapse video system.

    abstract:OBJECTIVE:To investigate the prevalence and potential causes of reverse cleavage (RC) by human early-cleavage embryos and its associations with embryonic development and implantation after transfer. DESIGN:Clinical retrospective cohort study. SETTING:Private fertility treatment center. PATIENT(S):A total of 126 cons...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Liu Y,Chapple V,Roberts P,Matson P

    更新日期:2014-11-01 00:00:00

  • Laparoscopic bipolar coagulation of uterine vessels: a new method for treating symptomatic fibroids.

    abstract:OBJECTIVE:To evaluate the effects of laparoscopic bipolar coagulation of uterine vessels in treating symptomatic fibroids. DESIGN:Prospective clinical study. SETTING:University-affiliated tertiary referral center. PATIENT(S):Eighty-seven women with symptomatic fibroids warranting surgical treatment and wanting to re...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Liu WM,Ng HT,Wu YC,Yen YK,Yuan CC

    更新日期:2001-02-01 00:00:00

  • Public perspectives on placing age limits on men and women seeking fertility treatment.

    abstract:OBJECTIVE:To assess public attitudes toward placing age limits on men and women seeking fertility treatment. DESIGN:Cross-sectional web-based survey. SETTING:Not applicable. PATIENT(S):A nationally representative sample of 1,427 adults in the United States. INTERVENTION(S):Not applicable. MAIN OUTCOME MEASURE(S):S...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lee MS,Farland LV,Thomas AM,Ginsburg ES

    更新日期:2019-03-01 00:00:00

  • A potential role for colony-stimulating factor 1 in the genesis of the early endometriotic lesion.

    abstract:OBJECTIVE:To investigate the role(s) of colony-stimulating factor 1 (CSF-1) on the development of early endometriosis in a murine model by comparing rate of lesion formation in mice [1] homozygous for a CSF-1 mutation versus syngeneic controls and [2] after treatment with imatinib, a commercially available tyrosine kin...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Jensen JR,Witz CA,Schenken RS,Tekmal RR

    更新日期:2010-01-01 00:00:00

  • Effect of halving the daily dose of triptorelin at the start of ovarian stimulation on hormone serum levels and the outcome of in vitro fertilization.

    abstract::Halving the standard daily dose of triptorelin at the start of ovarian stimulation in down-regulated women stimulated with recombinant FSH is enough for pituitary suppression and was associated with higher LH serum concentrations in the follicular phase. However, this did not translate into higher serum concentrations...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Fábregues F,Peñarrubia J,Creus M,Casamitjana R,Vanrell JA,Balasch J

    更新日期:2005-03-01 00:00:00

  • Follicle-stimulating hormone or human menopausal gonadotropin for ovarian stimulation in in vitro fertilization cycles: a meta-analysis.

    abstract:OBJECTIVE:To reanalyze the results of using FSH alone and hMG during IVF treatment, taking into account the different protocols of administration of superactive GnRH agonist analogs. DESIGN:Meta-analysis. SETTING:The London Women's Clinic. PATIENT(S):Women undergoing IVF treatment. INTERVENTION(S):A meta-analysis o...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,meta分析


    authors: Agrawal R,Holmes J,Jacobs HS

    更新日期:2000-02-01 00:00:00

  • The effect of three hormone replacement regimens on bone density in the aged ovariectomized rat.

    abstract:OBJECTIVE:To investigate the effects of estrogen (E) alone or with cyclic, continuous, or interrupted P regimens on bone density in an aged rat model. DESIGN:Randomized controlled trial. ANIMALS:Twenty 12-month-old female Sprague-Dawley rats were sham operated (intact control) and 100 were ovariectomized (OVX). INTE...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Vanin CM,MacLusky NJ,Grynpas MD,Casper RF

    更新日期:1995-03-01 00:00:00

  • Effect of freezing on the relative escape force of sperm as measured by a laser optical trap.

    abstract:OBJECTIVE:To determine the possible effect of freezing on sperm escape force as measured by laser trap. DESIGN:Controlled clinical study. SETTING:Normal volunteers, academic setting. PATIENTS:Normal, healthy volunteers. INTERVENTION:Sperm selection, freezing and thawing. Measurement of relative (sperm) escape force...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Dantas ZN,Araujo E Jr,Tadir Y,Berns MW,Schell MJ,Stone SC

    更新日期:1995-01-01 00:00:00

  • Pronuclear stage cryopreservation after intracytoplasmic sperm injection and conventional IVF: implications for timing of the freeze.

    abstract:OBJECTIVE:To compare clinical outcomes of frozen embryo transfers using cryopreserved pronuclear stage oocytes that had undergone either intracytoplasmic sperm injection (ICSI) or conventional IVF. DESIGN:Observational. SETTING:A tertiary referral reproductive medicine unit. PATIENT(S):Couples undergoing either ICSI...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Damario MA,Hammitt DG,Galanits TM,Session DR,Dumesic DA

    更新日期:1999-12-01 00:00:00

  • Factors affecting the pregnancy rate after microsurgical reversal of tubal ligation.

    abstract:OBJECTIVE:To evaluate the factors affecting the pregnancy rate after microsurgical reversal of tubal ligation. DESIGN:Retrospective clinical study. SETTING:Private practice affiliated with a tertiary care center. One hundred twenty-eight consecutive patients who underwent tubal reversal between October 1992 and May 2...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hanafi MM

    更新日期:2003-08-01 00:00:00

  • Significance of mRNA levels of connexin37, connexin43, and connexin45 in luteinized granulosa cells of controlled hyperstimulated follicles.

    abstract:OBJECTIVE:To evaluate the mRNA levels of connexins in different sizes of luteinized follicles. DESIGN:Semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) to determine the connexin mRNA levels in the granulosa cells of 91 luteinized follicles. SETTING:Academic tertiary care medical center and res...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Tsai MY,Lan KC,Huang KE,Huang FJ,Kung FT,Chang SY

    更新日期:2003-12-01 00:00:00

  • Role of follicle-stimulating hormone receptor Ser680Asn polymorphism in the efficacy of follicle-stimulating hormone.

    abstract:OBJECTIVE:To evaluate the association between FSH efficacy and FSHR alleles. DESIGN:Retrospective study. SETTING:University-based fertility unit and a private center for biomedical research. PATIENT(S):One hundred two women with ovarian function who were undergoing controlled ovarian stimulation (COS). Women were ca...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: de Castro F,Ruiz R,Montoro L,Pérez-Hernández D,Sánchez-Casas Padilla E,Real LM,Ruiz A

    更新日期:2003-09-01 00:00:00

  • Effect of different procedures of semen preparation on antibody-coated spermatozoa and immunological infertility.

    abstract::To assess whether procedures of semen preparation can reduce the proportion of antibody-coated spermatozoa, semen samples with positive direct mixed antiglobulin reaction (MAR) were washed in media supplemented with 10% or 50% fetal cord serum (FCS). Washing reduced the MAR to a negative level, but the MAR was identic...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hinting A,Vermeulen L,Goethals I,Dhont M,Comhaire F

    更新日期:1989-12-01 00:00:00

  • "Spot"-ting differences between the ectopic and eutopic endometrium of endometriosis patients.

    abstract:OBJECTIVE:To examine proteins aberrantly expressed in the ectopic endometrium compared with eutopic endometrium from the same patient. DESIGN:Experimental study. SETTING:Research institute and an obstetrics and gynecology clinic (National Institute for Research in Reproductive Health and Sanjeevani Diagnostic Center ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Chehna-Patel N,Sachdeva G,Gajbhiye R,Warty N,Khole V

    更新日期:2010-11-01 00:00:00

  • Population-based study of attitudes toward posthumous reproduction.

    abstract:OBJECTIVE:To measure public attitudes toward posthumous reproduction. DESIGN:Cross-sectional study. SETTING:Electronic survey. PATIENT(S):A total of 1,049 men and women living in the United States between the ages of 18 and 75 years. INTERVENTION(S):Multiple-choice questionnaire. MAIN OUTCOME MEASURE(S):Descriptiv...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Barton SE,Correia KF,Shalev S,Missmer SA,Lehmann LS,Shah DK,Ginsburg ES

    更新日期:2012-09-01 00:00:00

  • Effects of cigarette smoke on fertilization and embryo development in vivo.

    abstract:OBJECTIVE:To determine the effects of smoking on eggs and subsequent embryo development by maternal exposure to cigarette smoke. DESIGN:Mice were exposed to cigarette smoke or cigarette smoke condensate (CSC) for 4 weeks and then examined for development and telomere function of embryos in vitro after fertilization. I...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Huang J,Okuka M,McLean M,Keefe DL,Liu L

    更新日期:2009-10-01 00:00:00

  • Racial variation in tubal sterilization rates: role of patient-level factors.

    abstract:OBJECTIVE:To assess racial differences in attitudes and knowledge about sterilization. DESIGN:Cross-sectional survey. SETTING:Questionnaires were mailed to participants' home addresses. PATIENT(S):One hundred ninety-three women, aged 18-45, who had undergone tubal sterilization. INTERVENTION(S):None. MAIN OUTCOME ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Borrero S,Abebe K,Dehlendorf C,Schwarz EB,Creinin MD,Nikolajski C,Ibrahim S

    更新日期:2011-01-01 00:00:00

  • Follicular development in transplanted fetal and neonatal mouse ovaries is influenced by the gonadal status of the adult recipient.

    abstract:OBJECTIVE(S):To investigate the pattern of follicular development in transplanted fetal and neonatal mouse ovaries in the presence or absence of the recipient's own ovaries. DESIGN:Controlled experiment. SETTING:Academic research laboratory, Department of Physiology, Monash University, Clayton, Australia. INTERVENTI...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Cox S,Shaw J,Jenkin G

    更新日期:2000-08-01 00:00:00

  • The dilemma of endometriosis: is consensus possible with an enigma?

    abstract::Many will agree that the use of laparoscopy to diagnose and potientially treat endometriosis in patients who suffer from infertility has been superseded by IVF and sometimes oocyte donation, especially in older patients. The findings of our study add another dimension to management of endometriosis in the setting of i...

    journal_title:Fertility and sterility

    pub_type: 评论,杂志文章,评审


    authors: Nezhat C,Littman ED,Lathi RB,Berker B,Westphal LM,Giudice LC,Milki AA

    更新日期:2005-12-01 00:00:00

  • Opposing effects of dehydroepiandrosterone sulfate and free testosterone on metabolic phenotype in women with polycystic ovary syndrome.

    abstract:OBJECTIVE:To study the association of adrenal and ovarian androgen levels with metabolic parameters in a large cohort of women with polycystic ovary syndrome (PCOS). DESIGN:Cross-sectional study. SETTING:Outpatient clinic of an academic hospital. PATIENT(S):Six hundred twenty-two women with PCOS. INTERVENTION(S):No...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lerchbaum E,Schwetz V,Giuliani A,Pieber TR,Obermayer-Pietsch B

    更新日期:2012-11-01 00:00:00

  • Perinatal outcome of twin pregnancies after early transvaginal multifetal pregnancy reduction.

    abstract:OBJECTIVE:To compare the pregnancy outcomes of twin pregnancies following early transvaginal multifetal pregnancy reduction (MPR) with nonreduced twin gestations. DESIGN:Prospective cohort study. SETTING:Two tertiary medical centers. PATIENT(S):A cohort of 77 multiple pregnancies after reduction to twins and 78 dich...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,多中心研究


    authors: Haas J,Hourvitz A,Dor J,Elizur S,Yinon Y,Barzilay E,Shulman A

    更新日期:2014-05-01 00:00:00

  • Serum concentrations of interleukin-2R (IL-2R), IL-6, IL-8, and tumor necrosis factor alpha in patients with ectopic pregnancy.

    abstract:OBJECTIVE:To investigate the diagnostic relevance of serum cytokine concentrations in ectopic pregnancy (EP). DESIGN:Cohort study. SETTING:University hospital. PATIENT(S):Seventeen women with EP, 22 women with miscarriage, and 33 women with normal intrauterine pregnancy, at comparable stages of gestation. INTERVENT...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Soriano D,Hugol D,Quang NT,Darai E

    更新日期:2003-04-01 00:00:00

  • Understanding the genes involved in spermatogenesis: a progress report.

    abstract:OBJECTIVE:To review the current literature on genes known to affect fertility in the human and mouse. DESIGN:A literature review was performed and key articles were chosen for focus in the areas of genes with effects only on spermatogenesis and oogenesis, with an emphasis on Y-chromosome-encoded gene families and sper...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Cooke HJ,Hargreave T,Elliott DJ

    更新日期:1998-06-01 00:00:00

  • The zona pellucida-induced acrosome reaction of human spermatozoa is mediated by protein kinases.

    abstract:OBJECTIVE:To determine if the solubilized human zona pellucida (ZP)-induced acrosome reaction is mediated by protein kinases. DESIGN:Capacitated spermatozoa were incubated with inhibitors of cyclic adenosine 3':5'-monophosphate (cAMP)-dependent kinase (KT5720), Ca(2+)- and phospholipid-dependent kinase (Calphostin C),...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Bielfeld P,Faridi A,Zaneveld LJ,De Jonge CJ

    更新日期:1994-03-01 00:00:00

  • Healing and restoration of fertility following microsurgical transection and anastomosis of the rabbit oviduct.

    abstract::The postoperative time course of healing following tubal microsurgery was examined in the rabbit by transmission electron microscopy (TEM) and scanning electron microscopy (SEM) and was correlated with changes in fertility. Groups of animals were bred or used for morphologic studies on days 1, 2, 3, 4, 7, and 14 after...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Eddy CA,Bajpai VK

    更新日期:1982-09-01 00:00:00

  • The uterus and fertility.

    abstract:OBJECTIVE:To review the current understanding of the role the uterus plays in embryo implantation and to outline congenital anomalies and acquired diseases that impact normal uterine function. DESIGN:The publications related to the embryo implantation, Mullerian anomalies, uterine polyps, uterine synechiae, and myomas...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Taylor E,Gomel V

    更新日期:2008-01-01 00:00:00

  • Thrombin activatable fibrinolysis inhibitor and clot lysis time in women with recurrent miscarriage associated with the antiphospholipid syndrome.

    abstract::Antiphospholipid syndrome patients with recurrent miscarriage have an impairment in fibrinolysis demonstrated by prolonged clot lysis time (CLT) that cannot be attributed to differences in thrombin activatable fibrinolysis inhibitor (TAFI) antigen levels. Patients with unexplained recurrent miscarriage have an impairm...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Martínez-Zamora MA,Creus M,Tassies D,Bové A,Reverter JC,Carmona F,Balasch J

    更新日期:2010-11-01 00:00:00

  • Normal salivary progesterone levels throughout the ovarian cycle as determined by a direct enzyme immunoassay.

    abstract::This study, which is concerned with establishing clinically relevant corridors defining normal progesterone (P) levels in saliva, has addressed some of the shortcomings associated with previous equivalent studies (e.g., limited data, inadequately monitored ovulations, inadequately defined subjects). A sensitive, direc...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Finn MM,Gosling JP,Tallon DF,Madden AT,Meehan FP,Fottrell PF

    更新日期:1988-12-01 00:00:00

  • Gestrinone versus danazol as preoperative treatment for hysteroscopic surgery: a prospective, randomized evaluation.

    abstract:OBJECTIVE:To compare danazol and gestrinone treatment as preoperative endometrial preparation for operative hysteroscopy. DESIGN:Prospective, randomized clinical study. SETTING:University department of gynecological, obstetrical sciences and reproductive medicine. PATIENT(S):One hundred thirty-five patients with end...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Triolo O,De Vivo A,Benedetto V,Falcone S,Antico F

    更新日期:2006-04-01 00:00:00