Gonadotropin-releasing hormone agonist trigger in oocyte donors co-treated with a gonadotropin-releasing hormone antagonist: a dose-finding study.


OBJECTIVE:To determine the optimal GnRH agonist dose for triggering of oocyte maturation in oocyte donors. DESIGN:Single-center, randomized, parallel, investigator-blinded trial. SETTING:IVFMD, My Duc Hospital, Ho Chi Minh City, Vietnam. PATIENT(S):One hundred sixty-five oocyte donors (aged 18-35 years, body mass index [BMI] <28 kg/m(2), antimüllerian hormone level >1.25 ng/mL, and antral follicle count ≥6). INTERVENTION(S):Ovulation trigger with 0.2, 0.3, or 0.4 mg triptorelin in a GnRH antagonist cycle. MAIN OUTCOME MEASURE(S):The primary end point was number of metaphase II oocytes. Secondary end points were fertilization and cleavage rates, number of embryos and top-quality embryos, steroid levels, ovarian volume, and ongoing pregnancy rate (PR) in recipients. RESULT(S):There were no significant differences between the triptorelin 0.2, 0.3, and 0.4 mg trigger groups with respect to number of metaphase II oocytes (16.0 ± 8.5, 15.9 ± 7.8, and 14.7 ± 8.4, respectively), embryos (13.2 ± 7.8, 11.7 ± 6.9, 11.8 ± 7.0), and number of top-quality embryos (3.8 ± 2.9, 3.6 ± 3.0, 4.1 ± 3.0). Luteinizing hormone levels at 24 hours and 36 hours after trigger was significantly higher with triptorelin 0.4 mg versus 0.2 mg and 0.3 mg (9.8 ± 7.1 IU/L vs. 7.3 ± 4.1 IU/L and 7.2 ± 3.7 IU/L, respectively; 4.6 ± 3.2 IU/L vs. 3.2 ± 2.3 IU/L and 3.3 ± 2.1 IU/L, respectively. Progesterone level at oocyte pick-up +6 days was significantly higher in the 0.4-mg group (2.2 ± 3.7 ng/ml) versus 0.2 mg (1.1 ± 1.0 ng/ml) and 0.3 mg (1.2 ± 1.6 ng/ml). One patient developed early-onset severe ovarian hyperstimulation syndrome (OHSS). CONCLUSION(S):No significant differences between triptorelin doses of 0.2, 0.3, and 0.4 mg used for ovulation trigger in oocyte donors were seen with regard to the number of mature oocytes and top-quality embryos. CLINICAL TRIAL REGISTRATION NUMBER:NCT02208986.


Fertil Steril


Fertility and sterility


Vuong TN,Ho MT,Ha TD,Phung HT,Huynh GB,Humaidan P




Has Abstract


2016-02-01 00:00:00














  • Cyclic changes in the concentration of glucose and fructose in human cervical mucus.

    abstract:OBJECTIVE:To determine a possible cyclic change in the concentration of glucose and fructose in the aqueous phase of human cervical mucus (CM). DESIGN:Concentrations of glucose and fructose were longitudinally determined in the aqueous phase of CM of normal cycling women using enzymatic techniques, modified for small ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: van der Linden PJ,Kets M,Gimpel JA,Wiegerinck MA

    更新日期:1992-03-01 00:00:00

  • A new approach to ovarian reserve testing.

    abstract:OBJECTIVE:To critically examine ovarian reserve testing before assisted reproduction. DESIGN:A PUBMED computer search to identify relevant literature. SETTING:Multiple sites. PATIENT(S):Patients undergoing assisted reproduction. INTERVENTION(S):Testing for ovarian reserve. MAIN OUTCOME MEASURE(S):Assisted reproduc...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Sun W,Stegmann BJ,Henne M,Catherino WH,Segars JH

    更新日期:2008-12-01 00:00:00

  • Elevated serum estradiol associated with increased androstenedione-testosterone ratio in adolescent males with varicocele and gynecomastia.

    abstract:OBJECTIVE:To investigate the testicular function in adolescents with pubertal gynecomastia associated with varicocele before and after varicocelectomy. DESIGN AND PATIENTS:We have studied six male adolescents 15 to 19 years of age with bilateral gynecomastia. They were selected among other adolescents with gynecomasti...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Castro-Magana M,Angulo M,Uy J

    更新日期:1991-09-01 00:00:00

  • Reproductive endocrinologists are the gatekeepers for male infertility care in North America: results of a North American survey on the referral patterns and characteristics of men presenting to male infertility specialists for infertility investigations.

    abstract:OBJECTIVE:To characterize the referral patterns and characteristics of men presenting for infertility evaluation using data obtained from the Andrology Research Consortium. DESIGN:Standardized male infertility questionnaire. SETTING:Male infertility centers. PATIENT(S):Men presenting for fertility evaluation. INTER...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Samplaski MK,Smith JF,Lo KC,Hotaling JM,Lau S,Grober ED,Trussell JC,Walsh TJ,Kolettis PN,Chow VDW,Zini AS,Spitz A,Fischer MA,Domes T,Zeitlin SI,Fuchs EF,Hedges JC,Sandlow JI,Brannigan RE,Dupree JM,Goldstein M,Ko

    更新日期:2019-10-01 00:00:00

  • Uterine artery embolization versus myomectomy: a multicenter comparative study.

    abstract:OBJECTIVE:To determine whether there is significant quality of life score improvement after uterine artery embolization (UAE) and to compare UAE and myomectomy outcomes. DESIGN:Prospective cohort controlled study. SETTING:Sixteen medical centers in the United States. PATIENT(S):One hundred forty-nine UAE patients an...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,多中心研究


    authors: Goodwin SC,Bradley LD,Lipman JC,Stewart EA,Nosher JL,Sterling KM,Barth MH,Siskin GP,Shlansky-Goldberg RD,UAE versus Myomectomy Study Group.

    更新日期:2006-01-01 00:00:00

  • Luteal phase dysfunction in endometriosis: elevated progesterone levels in peripheral and ovarian veins during the follicular phase.

    abstract::Endometriosis has been associated with corpus luteum inadequacy and abnormalities of luteal phase progesterone (P) secretion. In this study, abnormal luteolysis, as a second factor of luteal dysfunction, was assessed in 13 women with endometriosis and 25 control patients by measurement of ovarian vein estradiol (E2) a...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ayers JW,Birenbaum DL,Menon KM

    更新日期:1987-06-01 00:00:00

  • Fertilization and cleavage after reinsemination of human oocytes in vitro.

    abstract::The results of reinsemination of 150 morphologically mature oocytes that failed to fertilize within 15 to 20 hours after initial insemination were evaluated. Only 41 oocytes (27.3%) were fertilized after reinsemination, which is significantly lower than the percentage obtained after initial insemination (74%). However...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ben-Rafael Z,Kopf GS,Blasco L,Tureck RW,Mastroianni L Jr

    更新日期:1986-01-01 00:00:00

  • The International Committee Monitoring Assisted Reproductive Technologies (ICMART) glossary on ART terminology.

    abstract::The International Committee Monitoring Assisted Reproductive Technologies (ICMART) is an independent international nonprofit organization that has taken a leading role in the development, collection, and dissemination of worldwide data on assisted reproductive technology (ART). Information on availability, efficacy, a...

    journal_title:Fertility and sterility



    authors: Zegers-Hochschild F,Nygren KG,Adamson GD,de Mouzon J,Lancaster P,Mansour R,Sullivan E,International Committee Monitoring Assisted Reproductive Technologies.

    更新日期:2006-07-01 00:00:00

  • Improved controlled ovarian hyperstimulation in poor responder in vitro fertilization patients with a microdose follicle-stimulating hormone flare, growth hormone protocol.

    abstract:OBJECTIVE:To assess the efficacy of a novel protocol-microdose GnRH agonist (GnRH-a), FSH, and GH, for the stimulation of IVF patients who were canceled previously on a standard luteal GnRH-a, FSH, GH protocol. DESIGN:Prospective evaluation using the patient's previous IVF stimulation attempt as historic controls. SE...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Schoolcraft W,Schlenker T,Gee M,Stevens J,Wagley L

    更新日期:1997-01-01 00:00:00

  • Virtual hysterosalpingography in the diagnosis of bicornuate versus septate uterus.

    abstract:OBJECTIVE:To study the value of virtual hysterosalpingography (VHSG) in the diagnosis of bicornuate vs. septate uterus. DESIGN:Retrospective study of all cases with bicornuate or septate uterus that had VHSG during the last 3 years at our center. SETTING:Private fertility center and radiology institute with universit...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Carrascosa P,Sueldo C,Capuñay C,Baronio M,Papier S

    更新日期:2011-11-01 00:00:00

  • Characterization of the injection funnel during intracytoplasmic sperm injection reflects cytoplasmic maturity of the oocyte.

    abstract:OBJECTIVE:To quantify cytoplasmic maturity on the basis of intracytoplasmic sperm injection (ICSI) injection funnel manifestation and to evaluate influence factors of the latter. DESIGN:Prospective study. SETTING:Private fertility center. PATIENT(S):A total of 31 patients with good ovarian response. INTERVENTION(S)...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Krause I,Pohler U,Grosse S,Shebl O,Petek E,Chandra A,Ebner T

    更新日期:2016-10-01 00:00:00

  • Percutaneous vasal sperm aspiration and intrauterine insemination for infertile males with anejaculation.

    abstract:OBJECTIVE:To explore the effectiveness of percutaneous vasal sperm aspiration (PVSA) in combination with intrauterine insemination (IUI) to treat infertile men with anejaculation. DESIGN:Clinical study. SETTING:Department of reproductive endocrinology and andrology of a family planning research clinic. PATIENT(S):Tw...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Qiu Y,Wang SM,Yang DT,Wang LG

    更新日期:2003-03-01 00:00:00

  • Serum supplement in human in vitro fertilization and embryo development.

    abstract::The effects of maternal preovulatory serum and human fetal cord serum supplement in culture medium in human in vitro fertilization and embryo development were compared in 208 cases over an 8-month period when there were no significant changes in other variables. A significantly higher pregnancy rate was observed in th...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Leung PC,Gronow MJ,Kellow GN,Lopata A,Speirs AL,McBain JC,du Plessis YP,Johnston I

    更新日期:1984-01-01 00:00:00

  • Consecutive cervical pregnancies.

    abstract:OBJECTIVE:Report of a rare case of consecutive spontaneous cervical pregnancies. DESIGN:Case study. SETTING:Teaching hospital. PATIENT(S):One healthy nulliparous woman in the early years of her fourth decade. INTERVENTION(S):The first of two cervical pregnancies was treated with two doses of methotrexate and subseq...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Radpour CJ,Keenan JA

    更新日期:2004-01-01 00:00:00

  • DNA microarray analysis of gene expression in eutopic endometrium from patients with deep endometriosis using laser capture microdissection.

    abstract:OBJECTIVE:To investigate differentially expressed genes in epithelial and stromal cells of eutopic endometrium from patients with deep endometriosis and women with normal pelvic cavities using laser capture microdissection and complementary DNA microarrays. DESIGN:Prospective study. SETTING:University hospital. PATI...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Matsuzaki S,Canis M,Vaurs-Barrière C,Boespflug-Tanguy O,Dastugue B,Mage G

    更新日期:2005-10-01 00:00:00

  • Peritoneal fluid and serum steroids in infertility patients.

    abstract::Peritoneal fluid and serum were collected from 78 patients at the time of laparoscopy. Twenty-two were fertile controls (CTL), and 56 were infertility patients, who were subdivided into three main groups: endometriosis (EMS), pelvic adhesions (ADH), and ovarian dysfunction (OvDF). Based on control group data, biochemi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lesorgen PR,Wu CH,Green PJ,Gocial B,Lerner LJ

    更新日期:1984-08-01 00:00:00

  • The presence of the 21-hydroxylase deficiency carrier status in hirsute women: phenotype-genotype correlations.

    abstract:OBJECTIVE:To determine the role of heterozygosity for mutations in the 21-hydroxylase gene (CYP21) in the pathogenesis of hyperandrogenism. DESIGN:Controlled clinical study. SETTING:Tertiary care institutional hospital. PATIENT(S):Forty hirsute women and 13 healthy control women. INTERVENTION(S):The source of andro...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Escobar-Morreale HF,San Millán JL,Smith RR,Sancho J,Witchel SF

    更新日期:1999-10-01 00:00:00

  • Prepubertal serum inhibin B in cryptorchid infants and in monorchid boys with compensatory testicular hypertrophy.

    abstract:OBJECTIVE:To investigate the prepubertal serum inhibin B levels in monorchid boys with compensatory testicular hypertrophy (CTH) and in surgically treated cryptorchid boys with normal testicular volume. DESIGN:Prospective study. SETTING:Pediatric Division, University of Verona, Italy. PATIENT(S):Thirty-two prepubert...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Gaudino R,Cavarzere P,Camilot M,Teofoli F,Zampieri N,Tatò L

    更新日期:2008-12-01 00:00:00

  • In vitro fertilization in couples with male factor infertility.

    abstract::The data from 83 consecutive in vitro fertilization-embryo transfer cycles were examined with emphasis on the presence of subfertile male parameters, including abnormal sperm density, motility, morphologic features, or an abnormal result in the sperm penetration assay (zona-free hamster ova penetration). There were 25...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hirsch I,Gibbons WE,Lipshultz LI,Rossavik KK,Young RL,Poindexter AN,Dodson MG,Findley WE

    更新日期:1986-05-01 00:00:00

  • Role of blood and fibrinogen in development of intraperitoneal adhesions in rats.

    abstract::One hundred and twenty rats were divided into six groups and laparotomized. In three of the groups the cecum was left intact. In one of these groups the cecum was only lifted up through the abdominal incision and then replaced in the abdominal cavity. In another group the intact cecum was bathed with a certain amount ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Nisell H,Larsson B

    更新日期:1978-10-01 00:00:00

  • Association study of AMH and AMHRII polymorphisms with unexplained infertility.

    abstract:OBJECTIVE:To investigate the association of AMH and AMHRII polymorphisms with reproductive abilities in a sample of women with idiopathic infertility. DESIGN:Case-control study. SETTING:University Department of Obstetrics and Gynecology, and University Unit of Clinical Genetics. PATIENT(S):76 women with idiopathic s...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Rigon C,Andrisani A,Forzan M,D'Antona D,Bruson A,Cosmi E,Ambrosini G,Tiboni GM,Clementi M

    更新日期:2010-09-01 00:00:00

  • Mouse embryo culture as quality control for human in vitro fertilization: the one-cell versus the two-cell model.

    abstract::Female mice were superovulated with pregnant mare serum gonadotropin (PMSG) and human chorionic gonadotropin (hCG) and mated with male mice. One-cell (n = 429) and 2-cell (n = 450) embryos were collected 20 and 42 hours after hCG and cultured in Ham's F-10 medium (Gibco, Grand Island, NY) (282 mOsm/l, pH 7.4) and in m...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Davidson A,Vermesh M,Lobo RA,Paulson RJ

    更新日期:1988-03-01 00:00:00

  • A tissue-engineered human endometrial stroma that responds to cues for secretory differentiation, decidualization, and menstruation.

    abstract:OBJECTIVE:To show the responsiveness of tissue-engineered human endometrial stroma to combinations of hormones that mimic the secretory and menstrual phases of the cycle. DESIGN:In vitro experimental study. SETTING:University uterine biology research laboratory. PATIENT(S):None. INTERVENTION(S):Telomerase immortali...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Schutte SC,Taylor RN

    更新日期:2012-04-01 00:00:00

  • Cross-sectional analysis of the effects of age on the hormonal, metabolic, and ultrasonographic features and the prevalence of the different phenotypes of polycystic ovary syndrome.

    abstract:OBJECTIVE:To assess the effects of age on the hormonal, metabolic, and ultrasonographic features of polycystic ovary syndrome (PCOS). DESIGN:Observational study. SETTING:University department of obstetrics and gynecology. PATIENT(S):Patients with PCOS (n = 1,212) and healthy women (n = 254). INTERVENTION(S):None. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Panidis D,Tziomalos K,Macut D,Delkos D,Betsas G,Misichronis G,Katsikis I

    更新日期:2012-02-01 00:00:00

  • Vitrification of the human embryo: a more efficient and safer in vitro fertilization treatment.

    abstract::Cryopreservation has become a central pillar in assisted reproduction, reflected in the exponential increase of "freeze all" cycles in the past few years. Vitrification makes it possible to cool and warm human eggs and embryos with far less cryo-damage than 'slow-freeze' and allows nearly intact survival of embryos wi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Nagy ZP,Shapiro D,Chang CC

    更新日期:2020-02-01 00:00:00

  • Effects of immunization with the beta-subunit of ovine luteinizing hormone on corpus luteum function in the rhesus monkey.

    abstract::Rhesus monkeys immunized with the beta-subunit of ovine luteinizing hormone (oLHbeta) developed circulating antibodies which cross-reacted strongly with rhesus monkey chorionic gonadotropin. Normal ovulatory cycles continued, but the fertility of immunized monkeys as compared with that of controls was significantly re...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Thau RB,Sundaram K,Thornton YS,Seidman LS

    更新日期:1979-02-01 00:00:00

  • Reproductive sequelae of parental severe illness before the pandemic: implications for the COVID-19 pandemic.

    abstract:OBJECTIVE:To investigate, with pre-COVID-19 data, whether parental exposure to severe systemic infections near the time of conception is associated with pregnancy outcomes. DESIGN:Retrospective cohort study. SETTING:Population-based study covering births within the United States from 2009 to 2016. PARTICIPANTS:The I...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kasman AM,Bhambhvani HP,Li S,Zhang CA,Stevenson DK,Shaw GM,Simard JF,Eisenberg ML

    更新日期:2020-12-01 00:00:00

  • Local injury of the endometrium induces an inflammatory response that promotes successful implantation.

    abstract:OBJECTIVE:To study whether an injury-induced inflammation might be the mechanism underlying the favorable effect of endometrial biopsy on the implantation rate in in vitro fertilization (IVF) patients. DESIGN:Controlled clinical study. SETTING:A medical center IVF unit and a research institute. PATIENT(S):Women unde...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Gnainsky Y,Granot I,Aldo PB,Barash A,Or Y,Schechtman E,Mor G,Dekel N

    更新日期:2010-11-01 00:00:00

  • Impact of infertility treatments on the health of newborns.

    abstract:OBJECTIVE:To measure the use of infertility treatments in the general population and their association with neonatal health. DESIGN:Cross-sectional, population-based study. SETTING:Canton of Vaud, Switzerland; Etude du Developpement des Nouveau-nés (EDEN), a prospective study of chronic childhood conditions. PATIENT...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Addor V,Santos-Eggimann B,Fawer CL,Paccaud F,Calame A

    更新日期:1998-02-01 00:00:00

  • Return of gonadotropic function in postpartum women during bromocriptine treatment.

    abstract::The rapid postpartum return of gonadotropic function during bromocriptine treatment was investigated through hormonal measurements in 15 women. Luteinizing hormone (LH) was measured by a novel and specific assay that does not cross-react with human chorionic gonadotropin (hCG). Prolactin was effectively suppressed by ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kremer JA,Rolland R,van der Heijden PF,Thomas CM,Lancranjan I

    更新日期:1989-04-01 00:00:00