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Distribution of type IV collagen subtypes in human testes and their association with spermatogenesis.

Abstract：

OBJECTIVE:To evaluate the expression of type IV collagen [alpha1(IV) to alpha6(IV)] in testes and the association with spermatogenesis. DESIGN:Retrospective immunohistochemical study. SETTING:Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, in a university hospital. PATIENT(S):Testicular biopsy specimens were obtained from 24 patients with varicocele, 5 with Sertoli cell-only syndrome (SCO), and 5 normal volunteers. INTERVENTION(S):Collection of testicular tissue and blood and semen sampling. RESULT(S):Expression of type IV collagen subtypes assessed by immunohistochemistry and clinical parameters such as seminogram and hormonal findings. In normal testes, the alpha1(IV) chain was seen in the basement membrane (BM) of seminiferous tubules as strongly stained irregular, wavy double lines, and the alpha2(IV) chain was slightly detected, whereas other testes showed little staining. In patients with varicocele and Sertoli cell-only syndrome, the BM was thicker and alpha1(IV) and alpha2(IV) chains were stained more intensely in the BM of seminiferous tubules than in normal testes. The expression of alpha1(IV) chain, not alpha2(IV), significantly correlated positively with the BM thickness, and negatively with sperm concentration, tubular diameter, and Johnsen score. CONCLUSION(S):Overabundance of the alpha1(IV) chain is associated with increased BM thickness and possibly related to spermatogenic dysfunction.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Dobashi M,Fujisawa M,Naito I,Yamazaki T,Okada H,Kamidono S

doi

10.1016/s0015-0282(03)00775-1

keywords:

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

755-60

eissn

0015-0282

issn

1556-5653

pii

S0015028203007751

journal_volume

80 Suppl 2

pub_type

杂志文章

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