Follicular development in transplanted fetal and neonatal mouse ovaries is influenced by the gonadal status of the adult recipient.

Abstract:

OBJECTIVE(S):To investigate the pattern of follicular development in transplanted fetal and neonatal mouse ovaries in the presence or absence of the recipient's own ovaries. DESIGN:Controlled experiment. SETTING:Academic research laboratory, Department of Physiology, Monash University, Clayton, Australia. INTERVENTION(S):Mouse ovaries from 16-day-old fetuses, 3-day-old neonates, and 10-day-old neonates were transplanted under the kidney capsule of adult female mice, which either retained their own ovaries in situ or were bilaterally ovariectomized. MAIN OUTCOME MEASURE(S):Histologic analysis. RESULT(S):By 4 weeks after transplantation, fetal and neonatal ovaries transplanted to ovariectomized recipients displayed a pattern of follicular development similar to that observed in in situ adult mouse ovaries. In contrast, follicular development did not progress beyond the early antral stage in fetal and 3-day-old ovaries transplanted to recipients that retained their in situ ovaries. However, 10-day-old ovaries transplanted to recipients that retained their in situ ovaries displayed full follicular development and corpora lutea formation by 8 weeks after transplantation. CONCLUSION(S):Follicular development in transplanted immature ovarian tissue is influenced by the age of the donor ovary and gonadal status of the recipient. (Fertil Steril(R) 2000;74:000-00. Copyright2000 by American Society for Reproductive Medicine.)

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Cox S,Shaw J,Jenkin G

doi

10.1016/s0015-0282(00)00635-x

keywords:

subject

Has Abstract

pub_date

2000-08-01 00:00:00

pages

366-71

issue

2

eissn

0015-0282

issn

1556-5653

pii

S001502820000635X

journal_volume

74

pub_type

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