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Repeated laparoscopic ovarian diathermy is effective in women with anovulatory infertility due to polycystic ovary syndrome.

Abstract：

OBJECTIVE:To assess the effectiveness of a second laparoscopic ovarian diathermy (LOD) in women with polycystic ovary syndrome (PCOS). DESIGN:Retrospective study. SETTING:Tertiary infertility clinic. PATIENT(S):Twenty anovulatory infertile women with PCOS who underwent LOD 1-6 years previously. Twelve subjects had previously responded positively to the first LOD, but the anovulatory status recurred (Group I), whereas eight subjects had not responded at all (Group II). INTERVENTION(S):Laparoscopic ovarian diathermy. MAIN OUTCOME MEASURE(S):Rates of ovulation, pregnancy and resumption of menstrual regularity, and biochemical changes. RESULT(S):An overall ovulation rate of 12 out of 20 women (60%) and a pregnancy rate of 10 out of 19 (53%) were achieved after the second LOD. In women (n = 12) who previously responded positively to the first LOD (LOD-sensitive), the ovulation and pregnancy rates were 10 out of 12 (83%) and 8 out of 12 women (67%), respectively, which were significantly (P<.05) higher than 2 out of 8 (25%) and 2 out of 7 (29%) of the previous nonresponders (LOD-resistant). Statistically significant hormonal changes including reduction of luteinizing hormone (LH), testosterone (T), and free androgen index (FAI) after the repeat LOD were only observed in the LOD-sensitive group. CONCLUSION(S):Repeat LOD is highly effective in women who previously responded to the first procedure.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Amer SA,Li TC,Cooke ID

doi

10.1016/s0015-0282(02)04960-9

keywords:

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

1211-5

issue

5

eissn

0015-0282

issn

1556-5653

pii

S0015028202049609

journal_volume

79

pub_type

杂志文章

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