Ovarian stimulation retards postimplantation development and alters global gene expression profile of blastocysts in mouse.

Abstract:

:This study compares the quality, developmental capacity and global gene expression profile of embryos generated from superovulated and natural cycles. We found that ovarian stimulation impaired quality of blastocysts (cell number: 68.9 +/- 6.9 vs. 76.8 +/- 7.9; diameter of blastocysts: 145.3 +/- 76.9 microm vs. 152.6 +/- 65.5 microm), fetus development (rate of development to term: 45.5% vs. 69.1%; weight of 18.5-dpc fetuses: 1.23 +/- 0.03 g vs. 1.34 +/- 0.03 g) and caused 92 genes differentially expressed.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Zhang X,Wang L,Li X,Li K,Fang J,Yao Y

doi

10.1016/j.fertnstert.2010.03.018

subject

Has Abstract

pub_date

2010-05-15 00:00:00

pages

2770-3

issue

8

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(10)00455-3

journal_volume

93

pub_type

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