Abstract:
OBJECTIVE:To assess the level of lipid peroxidation (LP) and vitamin E in the follicular fluid and serum of infertile patients, with or without endometriosis, who were submitted to ovulation induction for assisted reproduction procedures. DESIGN:Prospective study. SETTING:Assisted conception unit, university hospital. PATIENT(S):Infertile patients 20 to 38 years of age were selected prospectively and consecutively and were divided into the endometriosis group (17 patients with pelvic endometriosis) and the control group (19 patients with previous tubal ligation or male factor and without endometriosis). INTERVENTION(S):Peripheral blood samples were collected on D1 (before the beginning of the use of gonadotropins), D2 (day of hCG administration), and D3 (day of oocyte retrieval). On D3, follicular-fluid samples free from blood contamination also were collected and stored. MAIN OUTCOME MEASURE(S):Lipid peroxidation was assessed by malondialdehyde quantification by spectrophotometry, and measurement of vitamin E was performed by HLPC. RESULT(S):On D1, no significant difference in LP was observed between groups. However, vitamin E levels were significantly higher in the control group. On D2, LP levels were significantly higher in the endometriosis group compared with in the control group, and vitamin E levels continued to be significantly higher in the control group. On D3, there was no significant difference in serum and follicular-fluid levels of LP and vitamin E between groups. However, on D3, vitamin E levels were found to be significantly higher in serum than in follicular fluid in both groups, whereas malondialdehyde levels were significantly lower in follicular fluid than in serum only in the control group. CONCLUSION(S):Before the beginning of ovulation induction, a significant decrease in vitamin E was observed in patients with endometriosis, perhaps because antioxidants are consumed during oxidation reactions. After ovulation induction with exogenous gonadotropins, the group of patients with endometriosis not only presented increased lipid peroxidation but also maintained lower vitamin E levels than the control group, a fact that hypothetically could compromise oocyte quality in endometriotic patients. However, on the day of oocyte retrieval, both serum LP potential and vitamin E levels were found to be similar in the two groups.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Campos Petean C,Ferriani RA,dos Reis RM,de Moura MD,Jordão AA Jr,Navarro PAdoi
10.1016/j.fertnstert.2007.10.072subject
Has Abstractpub_date
2008-12-01 00:00:00pages
2080-5issue
6eissn
0015-0282issn
1556-5653pii
S0015-0282(07)03958-1journal_volume
90pub_type
临床试验,杂志文章abstract:OBJECTIVE:To explore endometriosis-related molecules in patients with use of differential display analysis. DESIGN:Prospective study. SETTING:Nagoya City University Medical School, Nagoya, Japan. PATIENT(S):Women with endometriosis (n = 27) and without endometriosis (n = 21). INTERVENTION(S):Surgery was scheduled i...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(99)00381-7
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:To investigate cell invasiveness and the production of matrix metalloproteinase-2 (MMP-2), MMP-9, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 in endometrial stromal cells (ESCs) of adenomyosis. DESIGN:Prospective study. SETTING:Tertiary university hospital. PATIENT(S):Twenty-one women with ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.05.090
更新日期:2009-05-01 00:00:00
abstract::Certain conclusions may be drawn from the present review: 1. Synthetic FSH/LH-RH may induce ovulation; therefore, a therapeutic effect has been established in some cases of anovulatory infertility, but it is still difficult to assess the correct dose of FSH/LH-RH because of individual variations in response. 2. Gonado...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)42188-6
更新日期:1976-11-01 00:00:00
abstract::This document will outline new delivery systems and contraceptive formulations, summarize recent advances in emergency contraception, and review the effects of hormonal contraception on cancer risks, cardiovascular disease, and bone. ...
journal_title:Fertility and sterility
pub_type: 指南,杂志文章,实务指引
doi:10.1016/j.fertnstert.2004.07.935
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:To assess whether provision of an educational DVD was more effective in increasing the uptake of elective single embryo transfers (eSET) than an educational brochure in an IVF population. DESIGN:Randomized controlled trial. SETTING:Private IVF clinic. PATIENT(S):One hundred thirty-one couples starting thei...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2009.03.080
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of supernumerary preovulatory follicular reduction as an approach to avoid multiple pregnancies in ovulation induction or superovulation cycles. DESIGN:Retrospective study. SETTING:Tertiary referral center. PATIENT(S):In 26 cycles, 24 patients underwent ovulation induction or superov...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(01)02379-2
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the importance of exogenous LH in poor responders undergoing IVF with GnRH antagonists. DESIGN:Retrospective cohort study. SETTING:University-based IVF center. PATIENT(S):All patients with a history of poor response to ovarian stimulation undergoing IVF with GnRH antagonists between September 2...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.02.028
更新日期:2005-08-01 00:00:00
abstract::The argon laser offers several theoretical advantages over excision, electrocautery, or CO2 laser therapy for the treatment of peritoneal implants of endometriosis. Therefore, a study of the feasibility of the argon laser for the treatment of endometriosis was performed using five virgin New Zealand White rabbits. Fol...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)46752-x
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of local endometrial injury (LEI) on clinical outcomes in ovum donation recipients. DESIGN:Retrospective cohort analysis of ovum donation cycles conducted from 2005 to 2012. SETTING:Two private IVF centers. PATIENT(S):Total 737 ovum donation cycles. INTERVENTION(S):LEI by endometria...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2014.06.044
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:To determine whether serum interleukin (IL)-8 concentration can be measured in patients with ovarian endometrioma and whether this measurement is a useful tool in diagnosing this disease. DESIGN:A controlled clinical study and an in vitro study. SETTING:Department of Obstetrics and Gynecology, Tottori Unive...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.07.1355
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of conjugated equine estrogens, medroxyprogesterone acetate (MPA), conjugated equine estrogens combined with MPA, tamoxifen, and soybean estrogens on vaginal cytology in surgically postmenopausal cynomolgus macaques (Macaca fascicularis). DESIGN:Randomized long-term experimental trial...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVE:To report a case of major intrauterine synechiae associated with ovarian function failure secondary to uterine devascularization. DESIGN:Case report. SETTING:Departments of gynecology and obstetrics in two hospitals in France. PATIENT(S):A 29-year-old woman, para 1, presenting severe postpartum hemorrhage....
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2004.07.975
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:To assess the effect of gonadotropin-releasing hormone agonist (GnRH-a) on pituitary suppression, subsequent ovarian response, and results of in vitro fertilization (IVF) treatments in polycystic ovarian syndrome (PCOS) patients. DESIGN:Randomized prospective study. SETTING:In vitro fertilization program an...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)54847-x
更新日期:1992-02-01 00:00:00
abstract:OBJECTIVE:To review osteoporosis, a disease characterized by low bone mass, microarchitectural deterioration of bone tissue leading to increased bone fragility and a consequent increase in fracture risk. The disorder has become a major health problem in the West, where increased life expectancy has placed new emphasis ...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:
更新日期:1994-12-01 00:00:00
abstract::We studied a prospective cohort of 434 couples in Northern California and found that 13% did not pursue any form of infertility treatment after their initial consultation. Although age, education, and financial concerns remain important for patients in choosing whether to pursue infertility treatment, depressive sympt...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.03.068
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:To reduce estrogen exposure in women with endometrial cancer undergoing in vitro fertilization using an aromatase inhibitor. DESIGN:Prospective case series. SETTING:Academic center for reproductive medicine. PATIENT(S):Endometrial carcinoma patients presenting for fertility preservation or fresh embryo tra...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2006.12.068
更新日期:2007-09-01 00:00:00
abstract::Hormonal profiles were compared in 14 ovulatory women who were treated with two different doses of gonadotropins in successive in vitro fertilization cycles. All patients suffered from mechanical causes of infertility. Serum estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and progesterone...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1988-06-01 00:00:00
abstract:OBJECTIVE:To determine whether antisperm autoantibody production after prepubertal vas injury is influenced by immediate repair of the vas compared to delay of the reanastomosis until sexual maturity. DESIGN:Animal study comparing early repair, late repair, and sham-operated groups. SETTING:Research laboratory in a m...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(99)00501-4
更新日期:2000-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the neuroendocrine responses to an intravenous L-tryptophan challenge across the menstrual cycle in women with premenstrual syndrome (PMS) and controls. DESIGN:Controlled clinical study. SETTING:The Clinical Research Center of an academic research environment. PATIENT(S):Women with PMS and heal...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(99)00452-5
更新日期:2000-01-01 00:00:00
abstract::Surgical treatments offer effective solutions for many couples experiencing male factor infertility. This Views and Reviews collection of articles offers a state-of-the-art overview of the surgical procedures commonly used to treat impaired male reproductive health. ...
journal_title:Fertility and sterility
pub_type:
doi:10.1016/j.fertnstert.2019.01.005
更新日期:2019-03-01 00:00:00
abstract::Caffeine (1, 3, 7-trimethyl-2, 6-dioxypurine), a cyclic nucleotide phosphodiesterase inhibitor, increased the motility of ejaculated human spermatozoa. Both the percent motility and the grade of forward progression were significantly increased (P smaller than 0.001) and maintained in the presence of 6 mM of caffeine f...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)40936-2
更新日期:1975-02-01 00:00:00
abstract::The serial measurement of serum hCG concentrations is an important clinical tool used to differentiate normal from abnormal pregnancies. At hCG values below which ultrasonography can be diagnostic, the comparison of a patient's hCG dynamics to those of established expected curves of rise or fall can aid the clinician ...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2012.09.014
更新日期:2012-11-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the extent to which increasing doses of exogenous testosterone (T) administered via Silastic implants can restore spermatogenesis and fertility to rats made azoospermic by active immunization against gonadotropin-releasing hormone (GnRH). DESIGN:Male rats were made azoospermic by active im...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55192-9
更新日期:1992-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the outcome of repeated electroejaculation for obtaining semen from adolescents and young men before initiation of anticancer therapies. DESIGN:Retrospective clinical study. SETTING:Bikur Cholim Hospital, Jerusalem, Israel. PATIENT(S):Six young male patients (average age, 18+/-3 years) with dia...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(01)01680-6
更新日期:2001-04-01 00:00:00
abstract:OBJECTIVES:To assess the impact of a levonorgestrel-releasing implant contraceptive (Norplant; Wyeth-Ayerst Laboratories, Philadelphia, PA) on glucose metabolism. DESIGN:Prospective evaluation of insulin action and secretion in women under hyperglycemic hyperinsulinemic clamp conditions in the midfollicular phase befo...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-04-01 00:00:00
abstract::We found that there was no significant difference in endometrial responses to vaginal or IM P. But the response was suboptimal in cycles treated with dydrogesterone, suggesting that dydrogesterone treatment is not the preferred progestin for use in artificial cycles. ...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0015-0282(16)56840-x
更新日期:1994-07-01 00:00:00
abstract::The serum levels of bioactive luteinizing hormone (LH), immunoreactive LH, follicle-stimulating hormone, androstenedione (A), and testosterone (T) were determined in nine anovulatory women with polycystic ovarian syndrome (PCOS) before and after laparoscopic ovarian cautery. Eight ovulated spontaneously and three conc...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53451-7
更新日期:1990-04-01 00:00:00
abstract:OBJECTIVE:To assess cycle outcomes when antimüllerian hormone (AMH) is ultralow (≤0.16 ng/mL) and to determine which parameters contribute to the probability of cycle cancellation and/or outcome. DESIGN:Retrospective analysis. SETTING:Not applicable. PATIENT(S):5,087 (7.3%) fresh and 243 (1.5%) thawed cycles with ul...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.10.004
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:To analyze the results of ongoing pregnancies and deliveries after assisted reproductive technology (ART) in women aged >/=41 years, stratified by year of age. DESIGN:Retrospective study. SETTING:University hospital, IVF unit. PATIENT(S):A total of 431 IVF and intracytoplasmic sperm injection (ICSI) cycles...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(00)00697-x
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:To report an update on the role of vitamin D (VD) in ovarian physiology with a focus on genes involved in steroidogenesis, follicular development, and ovarian reserve, as well as ovulatory dysfunction associated with polycystic ovary syndrome (PCOS), and ovarian response to assisted reproductive technology (A...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2014.04.046
更新日期:2014-08-01 00:00:00