Abstract:
:The current study was formulated to investigate the abortifacient activity of prostaglandin 15-methyl F2alpha (15-methyl PGF2alpha) administered intramuscularly to 80 healthy women with gestations between 8 and 22 weeks. Goals were the establishment of an effective dosage schedule and assessment of the incidence and severity of side effects. All 80 gravidas were aborted, with a mean time to abortion of 15.70 hours (SD, 6.52). Gastrointestinal side effects occurred in 89% of the patients; temperature elevations greater than or equal to 100.6 degrees F were noted in 14 cases. No other significant complications were encountered. Transabdominal intra-amniotic pressure monitoring indicated the need to administer the drug at 2-hour intervals. The 15-methyl PGF2alpha patients were matched for parity and gestational length with 80 gravidas aborted with PGE2 20-mg vaginal suppositories. The difference in interval to abortion in the two groups was not statistically significant. While gastrointestinal side effects were more common with 15-methyl PGF2alpha, the frequency of drug-induced temperature elevations was reduced. :It has been reported that intra-amniotic administration of 15-methyl PGF2a (prostaglandin F2alpha) for abortion results in a high level of uterine contractility, a high rate of success, and a low incidence of side effects. This study assesses the abortifacient activity of 15-methyl PGF2alpha administered intramuscularly in 80 healthy women aged 14 to 40 with gestational ages between 8 and 22 weeks. 56 patients were nulliparious. Transabdominal intra-amniotic pressure monitoring was used to measure uterine contractility and to establish an effective dose schedule. 350 to 520 mcg of 15-methyl PGF2a were administered intramuscularly at 2-hour intervals until the onset of abortion. Intravenous oxytocin was infused in 6 cases to facilitate passage of retained placental tissue. Medications were given to reduce diarrhea, vomiting, and pain. All patients aborted. Total drug dose ranged from 900 to 8400 mcg; mean dose was 3254.32 mcg. Duration of treatment ranged from 4 to 34 hours. Induction-abortion time ranged from 5.5 to 35 hours, with mean interval of 15.70 hours. 89% of the patients experienced gastrointestinal side effects. 14 patients had temperature elevation more than or equal to 100.6 degrees F. There were no significant complications. The 15-methyl PGF2a patients were matched with 80 gravidas who had abortion using PGE2 20 mg vaginal suppositories. There were no statistical differences in interval to abortion between the 2 groups.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Bolognese RJ,Corson SLkeywords:
subject
Has Abstractpub_date
1975-07-01 00:00:00pages
695-9issue
7eissn
0015-0282issn
1556-5653pii
S0015-0282(16)41237-9journal_volume
26pub_type
杂志文章abstract:OBJECTIVE:To study the changes in semen parameters, gonadotropic and sex hormones, and serum leptin in obese fertile and infertile oligozoospermic men. DESIGN:Prospective. SETTING:University hospital. PATIENT(S):Forty-two obese fertile and 80 obese infertile oligozoospermic men (body mass index [BMI] >30). INTERVEN...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.03.085
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:To assess how genetic evaluations of sperm donor applicants are performed in the United States. DESIGN:A questionnaire was designed to assess: 1) the professionals involved in the family history evaluation and genetic screening; 2) the genetic testing, counseling, and informed consent processes; and 3) how t...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究
doi:10.1016/j.fertnstert.2013.01.093
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:To determine efficacy and safety of asoprisnil in patients with leiomyomata. DESIGN:Phase 2, multicenter, prospective, randomized, double-blind, placebo-controlled, parallel-group study. SETTING:Twenty-eight sites in the United States and 1 in Canada. PATIENT(S):One hundred twenty-nine women with leiomyoma...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.fertnstert.2006.11.094
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:To present two exemplary cases of adenomatoid tumors. DESIGN:Case report. SETTING:Two laparoscopic centers in Germany. PATIENT(S):Two women of reproductive age with uterine adenomatoid tumors. INTERVENTION(S):Laparoscopic tumor excision. MAIN OUTCOME MEASURE(S):Differential diagnostics of uterine masses....
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2010.10.017
更新日期:2011-03-01 00:00:00
abstract::A case is described in which, after a tubal sterilization procedure and subsequent unilateral tubal anastomosis, an ectopic gestation occurred in the contralateral, unrepaired, distal tubal segment. On the basis of this case and related evidence, the authors suggest that in cases in which only a unilateral tubal anast...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)59068-2
更新日期:1987-03-01 00:00:00
abstract:OBJECTIVE:To demonstrate the laparoscopic neuroanatomy of the autonomic nerves of the pelvis using the laparoscopic neuronavigation technique, as well as the technique for a nerve-sparing radical endometriosis surgery. DESIGN:Step-by-step explanation of the technique using videos and pictures (educational video) to de...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.07.1138
更新日期:2015-11-01 00:00:00
abstract::Osteoporosis continues to be a major public health challenge in both women and men. There are more than 2 million low-impact fractures in the United States every year, 39% of which occur in men. The mortality rate in the first year after hip fracture is estimated at 20% to 25% in women and is even higher in men. The g...
journal_title:Fertility and sterility
pub_type:
doi:10.1016/j.fertnstert.2019.10.004
更新日期:2019-11-01 00:00:00
abstract::Since the late 1980s premature progesterone elevation has repeatedly caught the attention of investigators, not only for its importance, but also because studies have shown differing results and conclusions, constituting an unexplainable sequence of doubts and uncertainties. This issue's Views and Reviews section seek...
journal_title:Fertility and sterility
pub_type:
doi:10.1016/j.fertnstert.2018.02.134
更新日期:2018-04-01 00:00:00
abstract::We have previously observed that preimplantation embryo biopsy in the mouse causes a reduction in implantation rate in utero. After minor modifications to the technique, we now find that sampling a single blastomere from the 4-cell mouse embryo does not compromise continued development in vitro or in vivo. When transf...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60564-2
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness of growth hormone (GH) supplementation in improving the in vitro fertilization (IVF) outcomes of poor responders. DESIGN:Systematic review and meta-analysis. SETTING:Not applicable. PATIENT(S):Poor ovarian responders undergoing conventional IVF or intracytoplasmic sperm inject...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2020.03.007
更新日期:2020-07-01 00:00:00
abstract::In overweight women with polycystic ovary syndrome, weight loss improves arterial compliance and postprandial lipidemia. Modifying dietary carbohydrate or protein in weight loss provided similar improvements in arterial compliance and postprandial lipidemia. ...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2010.02.057
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:To evaluate whether ovarian function might have an influence on the adrenal hyperandrogenism present in patients with functional ovarian hyperandrogenism. DESIGN:Controlled clinical study. SETTING:Tertiary institutional hospital. PATIENT(S):Twenty-nine hirsute women with functional ovarian hyperandrogenism...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)81362-3
更新日期:1997-04-01 00:00:00
abstract::The reproductive history of 19 women with a diagnosis of unicornuate uterus confirmed by laparoscopy or laparotomy is analyzed. The patients were followed for 2 to 10 years. One patient had a cavitary communicating rudimentary horn, four a cavitary noncommunicating rudimentary horn, seven a noncavitary rudimentary hor...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)59047-5
更新日期:1987-03-01 00:00:00
abstract:OBJECTIVE:This study was designed to assess the ovarian response in the same patient in consecutive IVF cycles. DESIGN:Retrospective study. SETTING:Assisted reproductive unit at a university hospital. PATIENT(S):One hundred ninety women who underwent three consecutive cycles of IVF. INTERVENTION(S):All women used a...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(01)03237-x
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVE:To compare ovarian response to hyperstimulation during IVF between patients who did and did not undergo salpingectomy. DESIGN:Meta-analysis. SETTING:University-affiliated teaching hospital. PATIENT(S):Patients undergoing IVF who did and did not undergo salpingectomy. INTERVENTION(S):None. MAIN OUTCOME ME...
journal_title:Fertility and sterility
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.fertnstert.2016.03.053
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To investigate whether temporarily withholding FSH and adding androgen could improve follicular response during a microdose flare protocol in women with slow follicular growth or asynchronous follicular development. DESIGN:Observational pilot study. SETTING:University-affiliated private fertility center. P...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.09.038
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To consider the arguments for and against funding for in vitro fertilization (IVF) and to explore potential avenues for policy change. DESIGN:Narrative literature review, policy analysis. SETTING:University Department of Obstetrics and Gynecology. PATIENT(S):Sub-fertile women and men. INTERVENTION(S):Fert...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/s0015-0282(01)01928-8
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:To assess the association of total isoflavone intake with ovulatory function, including sporadic anovulation in healthy premenopausal women. DESIGN:Prospective cohort study. SETTING:University. PATIENT(S):Participants included 259 healthy regularly menstruating women aged 18-44 years. INTERVENTION(S):None...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2013.08.002
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:To investigate sperm viability, incidence of apoptosis, and intracellular basal and induced reactive oxygen species (ROS) in sperm fractions. DESIGN:Prospective controlled study. SETTING:Center for Reproductive Medicine at a tertiary care hospital. METHOD(S):Liquefied seminal ejaculates (n = 12) prepared b...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.10.068
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:To determine if the endometrium of women exposed in utero to diethylstilbestrol (DES) demonstrates altered integrin expression compared with normal fertile controls. DESIGN:Case control study. Expression of eight integrins in 15 luteal phase endometrial biopsies from DES-exposed women were compared with 17 b...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract::A monoclonal antibody that induces agglutination of human sperm was used to localize the interacting antigen in various tissues by indirect immunofluorescence. The antibody localized to the immature sperm and Sertoli cells of the seminiferous tubules, simple cuboidal epithelial cells of the rete testis, and the column...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)48147-1
更新日期:1984-10-01 00:00:00
abstract:OBJECTIVE:To evaluate surgical outcome and long-term follow-up of conservative laparoscopic management of urinary tract endometriosis (UTE). DESIGN:Prospective study. SETTING:Tertiary-care university hospital. PATIENT(S):Women with laparoscopic diagnosis and histologic confirmation of urinary bladder or ureteral end...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/j.fertnstert.2009.04.019
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus (T2DM) in Korean women. DESIGN:Longitudinal case-control study. SETTING:Not applicable. PATIENT(S):PCOS patients aged 15 to 44 years (n = 1,136) and control individuals (n = 5,675), matched 1:5 by age grou...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2020.12.018
更新日期:2021-01-25 00:00:00
abstract:OBJECTIVE:To determine the influence of ejaculatory abstinence on within-subject semen parameters and DNA fragmentation. DESIGN:Prospective study. SETTING:Private infertility institute and university-based research laboratory. PATIENT(S):Sixteen consenting male volunteers undergoing infertility investigation. INTER...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2004.03.014
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:To assess the hypothesis that pregnancy rates (PRs) after operative laparoscopy (Laparoscopy Group) for endometriosis treatment would be equal to or greater than diagnostic laparoscopy only (No Treatment Group), diagnostic laparoscopy with medical treatment (Medical Treatment Group), and laparotomy (Laparotom...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::A highly sensitive 2-hour tube test for the detection of human chorionic gonadotropin (hCG) in urine was compared with the more resource-demanding radioimmunoassay for hCG in serum as an aid in the diagnosis of ectopic pregnancy. In a first series of 107 patients with the possibility of ectopic pregnancy, the urine te...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)48559-6
更新日期:1985-05-01 00:00:00
abstract::The assessment of anti-phospholipid antibodies (APA) is not indicated among couples undergoing IVF, and therapy is not justified on the basis of existing data. ...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2008.08.100
更新日期:2008-11-01 00:00:00
abstract::Examination of 12 paired peritoneal ectopic and eutopic endometria for histochemical binding of Dolichos biflorus agglutinin, normally found in the mid-late secretory part of the cycle, showed a failure of lectin binding in 9 of 11 secretory-phase lesions although the eutopic specimens generally stained normally. This...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.11.032
更新日期:2009-04-01 00:00:00
abstract::Moderate ovarian hyperstimulation syndrome occurred after LA was administered to control menorrhagia in an anephric woman who required hemodialysis. We postulate that women who require dialysis may be at special risk for the development of this syndrome. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)54142-9
更新日期:1991-02-01 00:00:00
abstract::In vitro fertilization and embryo transfer (IVF-ET) and gamete intrafallopian transfer (GIFT) are used to treat intractable infertility in women with no distortion of the pelvic viscera, despite the lack of controlled trials demonstrating efficacy. The mechanism of any purportedly enhanced cycle fecundity in ovulatory...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)59414-x
更新日期:1987-09-01 00:00:00