Interruption of pregnancy by prostaglandin 15-methyl F2alpha.


:The current study was formulated to investigate the abortifacient activity of prostaglandin 15-methyl F2alpha (15-methyl PGF2alpha) administered intramuscularly to 80 healthy women with gestations between 8 and 22 weeks. Goals were the establishment of an effective dosage schedule and assessment of the incidence and severity of side effects. All 80 gravidas were aborted, with a mean time to abortion of 15.70 hours (SD, 6.52). Gastrointestinal side effects occurred in 89% of the patients; temperature elevations greater than or equal to 100.6 degrees F were noted in 14 cases. No other significant complications were encountered. Transabdominal intra-amniotic pressure monitoring indicated the need to administer the drug at 2-hour intervals. The 15-methyl PGF2alpha patients were matched for parity and gestational length with 80 gravidas aborted with PGE2 20-mg vaginal suppositories. The difference in interval to abortion in the two groups was not statistically significant. While gastrointestinal side effects were more common with 15-methyl PGF2alpha, the frequency of drug-induced temperature elevations was reduced. :It has been reported that intra-amniotic administration of 15-methyl PGF2a (prostaglandin F2alpha) for abortion results in a high level of uterine contractility, a high rate of success, and a low incidence of side effects. This study assesses the abortifacient activity of 15-methyl PGF2alpha administered intramuscularly in 80 healthy women aged 14 to 40 with gestational ages between 8 and 22 weeks. 56 patients were nulliparious. Transabdominal intra-amniotic pressure monitoring was used to measure uterine contractility and to establish an effective dose schedule. 350 to 520 mcg of 15-methyl PGF2a were administered intramuscularly at 2-hour intervals until the onset of abortion. Intravenous oxytocin was infused in 6 cases to facilitate passage of retained placental tissue. Medications were given to reduce diarrhea, vomiting, and pain. All patients aborted. Total drug dose ranged from 900 to 8400 mcg; mean dose was 3254.32 mcg. Duration of treatment ranged from 4 to 34 hours. Induction-abortion time ranged from 5.5 to 35 hours, with mean interval of 15.70 hours. 89% of the patients experienced gastrointestinal side effects. 14 patients had temperature elevation more than or equal to 100.6 degrees F. There were no significant complications. The 15-methyl PGF2a patients were matched with 80 gravidas who had abortion using PGE2 20 mg vaginal suppositories. There were no statistical differences in interval to abortion between the 2 groups.


Fertil Steril


Fertility and sterility


Bolognese RJ,Corson SL



Has Abstract


1975-07-01 00:00:00














  • Impact of obesity on women's health.

    abstract:OBJECTIVE:To review the impacts of obesity on women's reproductive health and fertility. DESIGN:Literature review. SETTING:Academic medical center. PATIENT(S):Forty articles are referenced. The number of patients evaluated in each of the studies varies from 33 to 213,208. INTERVENTION(S):Articles were identified fr...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lash MM,Armstrong A

    更新日期:2009-05-01 00:00:00

  • A firstborn boy is suggestive of a strong prognostic factor in secondary recurrent miscarriage: a confirmatory study.

    abstract:OBJECTIVE:To test our previously generated hypothesis that women with secondary recurrent miscarriages with a firstborn boy have a poorer pregnancy prognosis than those with a firstborn girl. DESIGN:A study of a retrospective and a prospective cohort. SETTING:The Danish recurrent miscarriage clinic. PATIENT(S):Two c...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Nielsen HS,Andersen AM,Kolte AM,Christiansen OB

    更新日期:2008-04-01 00:00:00

  • The M235T polymorphism of the angiotensinogen gene in women with polycystic ovary syndrome.

    abstract::To explore the relationship between variation in AGT M235T gene and the development of the polycystic ovary syndrome (PCOS) and its sequelae, in the present study we evaluated AGT polymorphism M235T in women with PCOS and in a control group. Moreover, to detect any relationship between AGT M235T variation and intermed...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Zulian E,Sartorato P,Schiavi F,Moghetti P,Castello R,Mantero F,Opocher G,Scaroni C

    更新日期:2005-11-01 00:00:00

  • Lipid peroxidation and vitamin E in serum and follicular fluid of infertile women with peritoneal endometriosis submitted to controlled ovarian hyperstimulation: a pilot study.

    abstract:OBJECTIVE:To assess the level of lipid peroxidation (LP) and vitamin E in the follicular fluid and serum of infertile patients, with or without endometriosis, who were submitted to ovulation induction for assisted reproduction procedures. DESIGN:Prospective study. SETTING:Assisted conception unit, university hospital...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Campos Petean C,Ferriani RA,dos Reis RM,de Moura MD,Jordão AA Jr,Navarro PA

    更新日期:2008-12-01 00:00:00

  • Studies of carbohydrate and lipid metabolism in women using the progesterone-T intrauterine device for six months: blood glucose, insulin, cholesterol, and triglyceride levels.

    abstract::A prospective, detailed study of both lipid and carbohydrate metabolism was carried out in 35 women who used a progesterone-T type intrauterine device (IUD). A 3-hour oral glucose tolerance test was performed in each woman before the IUD was inserted and again after 6 months of use. There was no change in the patient...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Spellacy WN,Buhi WC,Birk SA

    更新日期:1978-05-01 00:00:00

  • Autoimmunity and reproduction.

    abstract:OBJECTIVE:To review the association between autoimmunity and reproductive failure. DESIGN:A MEDLINE search done from 1965 to 1996. More than 300 original and review articles were evaluated, from which the most relevant were selected. RESULT(S):Autoimmune processes now are accepted widely as one of the possible mechan...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Geva E,Amit A,Lerner-Geva L,Lessing JB

    更新日期:1997-04-01 00:00:00

  • Successful pregnancies in women with diffuse uterine leiomyomatosis after hysteroscopic management.

    abstract:OBJECTIVE:To describe the surgical and reproductive outcomes of early diffuse uterine leiomyomatosis with hysteroscopic myomectomy. DESIGN:Retrospective report. SETTING:University hospital. PATIENT(S):Five consecutive women of reproductive age with innumerable small-sized (0.5-3 cm) diffuse uterine myomas with profu...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Yen CF,Lee CL,Wang CJ,Soong YK,Arici A

    更新日期:2007-12-01 00:00:00

  • Lack of effect of short-term diazoxide administration on luteinizing hormone secretion in women with polycystic ovary syndrome.

    abstract:OBJECTIVE:To test the hypothesis that an acute reduction in circulating insulin affects LH secretion in women with polycystic ovary syndrome (PCOS). DESIGN:Prospective study in normal and PCOS women. SETTING:General Clinical Research Centers at the University of Virginia, the Medical College of Virginia, and the Mass...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Evans WS,Taylor AE,Boyd DG,Johnson ML,Matt DW,Jimenez Y,Nestler JE

    更新日期:2007-07-01 00:00:00

  • Random anti-Müllerian hormone (AMH) is a predictor of ovarian response in women with elevated baseline early follicular follicle-stimulating hormone levels.

    abstract:OBJECTIVE:To investigate the utility of random anti-Müllerian hormone (AMH) in assessing ovarian response among women with diminished ovarian reserve (DOR) diagnosed by elevated early follicular-phase FSH levels. DESIGN:Retrospective study. SETTING:Academic and academically affiliated assisted reproductive technology...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Buyuk E,Seifer DB,Younger J,Grazi RV,Lieman H

    更新日期:2011-06-01 00:00:00

  • Two cases of cholestasis in the first trimester of pregnancy after ovarian hyperstimulation.

    abstract:OBJECTIVE:To report two cases of early onset cholestasis of pregnancy associated with IVF and ovarian hyperstimulation syndrome. DESIGN:Case report. SETTING:University-based IVF program. PATIENT(S):Two patients with first-trimester cholestasis of pregnancy after IVF that was associated with ovarian hyperstimulation ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Zamah AM,El-Sayed YY,Milki AA

    更新日期:2008-10-01 00:00:00

  • Outcome of ovarian stimulation for oocyte cryopreservation in women with Turner syndrome.

    abstract:OBJECTIVE:To study the safety and efficacy of ovarian stimulation and oocyte cryopreservation as a method of fertility preservation in women with Turner syndrome (TS). DESIGN:Retrospective cohort study. SETTING:Reproductive medicine clinic. PATIENT(S):Seven women with TS who attended the clinic between 2011 and 2017...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Talaulikar VS,Conway GS,Pimblett A,Davies MC

    更新日期:2019-03-01 00:00:00

  • Interaction between human cervical mucus and sperm surface antibodies.

    abstract::The immunobead test was used to study the immunoglobulin class of antibodies on sperm before and after penetration through a microcolumn of cervical mucus. Sixteen men with positive sperm antibodies (positive sperm immobilization test) and sperm that penetrated cervical mucus in prior tests were selected for study. Ho...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Wang C,Baker HW,Jennings MG,Burger HG,Lutjen P

    更新日期:1985-10-01 00:00:00

  • Restoration of cyclic ovarian function by metergoline treatment in a patient with a prolactin-secreting pituitary microadenoma.

    abstract::A patient with amenorrhea due to a prolactin-secreting pituitary microadenoma was treated with the antiserotoninergic drug metergoline for 8 months. The first menstruation occurred after 1 month of therapy, and it was followed by regular menses by the 3rd month. Presumptive evidence of ovulation was obtained in at lea...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ferrari C,Caldara R,Telloli P,Rampini P,Bertazzoni A

    更新日期:1978-08-01 00:00:00

  • Nonapoptotic effects of tumor necrosis factor-related apoptosis-inducing ligand on interleukin-6, leukemia inhibitory factor, interleukin-8, and monocyte chemoattractant protein 1 vary between undifferentiated and decidualized human endometrial stromal ce

    abstract::Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which is known to exert death-inducing as well as nonapoptotic functions, has been shown to be expressed by the early trophoblast. Here we report that TRAIL has no apoptotic effects on human endometrial stromal cells, but differentially regulates cytokin...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Fluhr H,Sauter G,Steinmüller F,Licht P,Zygmunt M

    更新日期:2009-10-01 00:00:00

  • Effects of dydrogesterone and of its stable metabolite, 20-alpha-dihydrodydrogesterone, on nitric oxide synthesis in human endothelial cells.

    abstract:OBJECTIVE:To investigate the effects of P, medroxyprogesterone acetate (MPA), and dydrogesterone (DYD) and its metabolite, 20-alpha-dihydrodydrogesterone (DHD) on endothelial synthesis of nitric oxide (NO) and characterize the signaling events recruited by these compounds. The Women's Health Initiative trial reports an...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Simoncini T,Caruso A,Giretti MS,Scorticati C,Fu XD,Garibaldi S,Baldacci C,Mannella P,Fornari L,Genazzani AR

    更新日期:2006-10-01 00:00:00

  • Why lose an in vitro fertilization cycle when stimulation fails?

    abstract::Different protocols using agonists of GnRH-a have been proposed for the ovarian stimulation in IVF cycles. In case of stimulation failure with the flare-up protocol, we have investigated whether an immediate switch to pituitary blockade by the long-acting analog may avoid the cycle to be canceled. This procedure allow...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Germond M,Senn A,Reymond O,de Grandi P

    更新日期:1990-05-01 00:00:00

  • Effect of long-term intranasal oxytocin on sexual dysfunction in premenopausal and postmenopausal women: a randomized trial.

    abstract:OBJECTIVE:To assess the effect of on-demand intranasal oxytocin administration on female sexual function and activity. DESIGN:Randomized, prospective, double-blind, placebo-controlled, crossover trial with duration of 22 weeks. SETTING:Academic medical center. PATIENT(S):Thirty pre-and postmenopausal women with sexu...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Muin DA,Wolzt M,Marculescu R,Sheikh Rezaei S,Salama M,Fuchs C,Luger A,Bragagna E,Litschauer B,Bayerle-Eder M

    更新日期:2015-09-01 00:00:00

  • Prenatal hyperandrogenism and lipid profile during different age stages: an experimental study.

    abstract:OBJECTIVE:The present study investigates the effect of prenatal hyperandrogenization on lipid metabolism and oxidant/antioxidant balance. DESIGN:Experimental study. SETTING:Research institute. ANIMAL(S):Pregnant Sprague Dawley rats were subcutaneously injected with 2 mg free T between days 16 and 19 of pregnancy, an...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Heber MF,Ferreira SR,Vélez LM,Motta AB

    更新日期:2013-02-01 00:00:00

  • Danazol binding to rat androgen, glucocorticoid, progesterone, and estrogen receptors: correlation with biologic activity.

    abstract::Danazol was found to possess androgenic and glucocorticoid activity in rat bioassays. In contrast, danazol displayed no significant estrogenic activity. In support of these findings, danazol bound to the 8 S androgen receptor of rat prostate cytosol and to the glucocorticoid receptor of rat liver cytosol, but danazol ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Barbieri RL,Lee H,Ryan KJ

    更新日期:1979-02-01 00:00:00

  • Distribution of type IV collagen subtypes in human testes and their association with spermatogenesis.

    abstract:OBJECTIVE:To evaluate the expression of type IV collagen [alpha1(IV) to alpha6(IV)] in testes and the association with spermatogenesis. DESIGN:Retrospective immunohistochemical study. SETTING:Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, in a university hospital. PATIENT(S):Testicular ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Dobashi M,Fujisawa M,Naito I,Yamazaki T,Okada H,Kamidono S

    更新日期:2003-09-01 00:00:00

  • Postmolar gestational trophoblastic neoplasia: beyond the traditional risk factors.

    abstract:OBJECTIVE:To investigate the slope of linear regression of postevacuation serum hCG as an independent risk factor for postmolar gestational trophoblastic neoplasia (GTN). DESIGN:Multicenter retrospective cohort study. SETTING:Academic referral health care centers. PATIENT(S):All subjects with confirmed hydatidiform ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,多中心研究


    authors: Bakhtiyari M,Mirzamoradi M,Kimyaiee P,Aghaie A,Mansournia MA,Ashrafi-Vand S,Sarfjoo FS

    更新日期:2015-09-01 00:00:00

  • Variations in seminal plasma constituents from fertile, subfertile, and vasectomized azoospermic men.

    abstract::Freshly ejaculated semen specimens from 20 normal fertile, 11 subfertile, and 20 vasectomized men whose semen analyses had reached complete azoospermia were compared. The mean levels of seminal acid phosphatase were significantly higher in the vasectomized men. The mean values of sialic acid in normal and postvasect...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Nun S,Musacchio I,Epstein JA

    更新日期:1972-05-01 00:00:00

  • Pronuclear stage cryopreservation after intracytoplasmic sperm injection and conventional IVF: implications for timing of the freeze.

    abstract:OBJECTIVE:To compare clinical outcomes of frozen embryo transfers using cryopreserved pronuclear stage oocytes that had undergone either intracytoplasmic sperm injection (ICSI) or conventional IVF. DESIGN:Observational. SETTING:A tertiary referral reproductive medicine unit. PATIENT(S):Couples undergoing either ICSI...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Damario MA,Hammitt DG,Galanits TM,Session DR,Dumesic DA

    更新日期:1999-12-01 00:00:00

  • The effect of gonadotropin-releasing hormone agonists on growth hormone secretion in adult premenopausal women.

    abstract::Suppression of the pituitary-gonadal axis by the administration of gonadotropin-releasing hormone agonists (GnRH-a) has been used for a variety of endocrinological and gynecological disorders. The suppressive effect of GnRH-a on luteinizing hormone, follicle-stimulating hormone, and sex steroid production is well docu...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Word RA,Odom MJ,Byrd W,Carr BR

    更新日期:1990-07-01 00:00:00

  • Robotic-assisted laparoscopic surgery: recent advances in urology.

    abstract::The aim of the present review is to summarize recent developments in the field of urologic robotic surgery. A nonsystematic literature review was performed to retrieve publications related to robotic surgery in urology and evidence-based critical analysis was conducted by focusing on the literature of the past 5 years...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Autorino R,Zargar H,Kaouk JH

    更新日期:2014-10-01 00:00:00

  • Gonadotropin-releasing hormone agonists for the preservation of ovarian function among women with breast cancer who did not use tamoxifen after chemotherapy: a systematic review and meta-analysis.

    abstract:OBJECTIVE:To determine whether concurrent use of GnRH agonists with chemotherapy preserves ovarian function in women with breast cancer who did not use tamoxifen. DESIGN:Systematic review and meta-analysis. SETTING:University-based hospitals. PATIENT(S):Premenopausal women with breast cancer treated with chemotherap...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,meta分析,评审


    authors: Vitek WS,Shayne M,Hoeger K,Han Y,Messing S,Fung C

    更新日期:2014-09-01 00:00:00

  • Intercycle variability of the ovarian response in patients undergoing repeated stimulation with corifollitropin alfa in a gonadotropin-releasing hormone antagonist protocol.

    abstract:OBJECTIVE:To determine whether individual subject variation in ovarian response between repeated cycles with the same ovarian stimulation protocol can be predicted. DESIGN:Retrospective data analysis. SETTING:Multicenter, open-label, uncontrolled clinical trial. PATIENT(S):Women aged 18-39 from a phase 3, open-label...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,多中心研究


    authors: Rombauts L,Lambalk CB,Schultze-Mosgau A,van Kuijk J,Verweij P,Gates D,Gordon K,Griesinger G

    更新日期:2015-10-01 00:00:00

  • Does the level of serum antimüllerian hormone predict ovulatory function in women with polycystic ovary syndrome with aging?

    abstract:OBJECTIVE:To determine possible prediction of regular menses with aging in anovulatory women with polycystic ovary syndrome (PCOS). DESIGN:Cohort. SETTING:Academic practice. PATIENT(S):A total of 54 anovulatory women with PCOS and 28 age- and weight-matched control subjects. INTERVENTION(S):Blood and ovarian ultras...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Carmina E,Campagna AM,Mansuet P,Vitale G,Kort D,Lobo R

    更新日期:2012-10-01 00:00:00

  • The changing face of peer review at the National Institutes of Health.

    abstract:OBJECTIVE:To discuss the new peer review system at the National Institutes of Health (NIH) and to present the process undertaken to accomplish these changes, with an emphasis on the reproductive sciences. DESIGN:A discussion of the many NIH committees and their composition and reports leading to the changes in peer re...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Leppert PC

    更新日期:2004-02-01 00:00:00

  • Carbohydrate and lipid studies in women using the progesterone intrauterine device for one year.

    abstract::Carbohydrate and lipid metabolism was evaluated in 31 women before and after 1 year's use of a progesterone-releasing intrauterine device. The studies involved measuring blood glucose and plasma insulin levels during a 3-hour oral glucose tolerance test and also measuring fasting cholesterol and triglyceride levels. T...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Spellacy WN,Buhi WC,Birk SA

    更新日期:1979-04-01 00:00:00