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Prolonged stimulation with tumor necrosis factor-alpha induced partial methylation at PR-B promoter in immortalized epithelial-like endometriotic cells.

Abstract：

:The promoter of P receptor isoform B (PR-B) has recently been shown to be hypermethylated in endometriotic tissues, but one question remains as what causes the aberrant methylation. We show that sustained stimulation of an epithelial-like endometriotic cell line with tumor necrosis factor alpha stimulation for 30 days induced partial methylation in the promoter region of PR-B with concomitant reduction of PR-B expression.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Wu Y,Starzinski-Powitz A,Guo SW

doi

10.1016/j.fertnstert.2007.06.008

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

234-7

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(07)01257-5

journal_volume

90

pub_type

杂志文章

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