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Autoimmune oophoritis as a mechanism of follicular dysfunction in women with 46,XX spontaneous premature ovarian failure.

Abstract：

OBJECTIVE:To assess the association between serum adrenal cortex autoantibodies and histologically confirmed autoimmune lymphocytic oophoritis. DESIGN:Controlled, prospective. SETTING:Tertiary research center. PATIENT(S):Two hundred sixty-six women with 46,XX spontaneous premature ovarian failure. INTERVENTION(S):Ovarian biopsy in 10 women. MAIN OUTCOME MEASURE(S):Serum adrenal cortex autoantibodies assessed by indirect immunofluorescence and autoimmune oophoritis assessed by immunohistochemical lymphocyte markers. RESULT(S):We obtained a histologic diagnosis of autoimmune oophoritis in four women who tested positive for adrenal cortex autoantibodies and excluded this diagnosis in ovarian biopsies from six women who tested negative for adrenal cortex autoantibodies (4/4 vs. 0/6). Women with histologically confirmed autoimmune oophoritis had a greater total ovarian volume as assessed by transvaginal sonography (11.4 +/- 5.6 mL vs. 1.5 +/- 0.4 mL) (mean +/- SEM). They were also more likely to have subclinical adrenal insufficiency and clinical signs of androgen deficiency (3/4 vs. 0/6). Overall, 10/266 women tested positive for adrenal cortex autoantibodies (3.8%, 95% confidence interval: 1.8%-6.5%). CONCLUSION(S):In women who present with 46,XX spontaneous premature ovarian failure as their primary concern there is a clear association between serum adrenal cortex autoantibodies and the presence of histologically confirmed autoimmune oophoritis.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Bakalov VK,Anasti JN,Calis KA,Vanderhoof VH,Premkumar A,Chen S,Furmaniak J,Smith BR,Merino MJ,Nelson LM

doi

10.1016/j.fertnstert.2005.04.060

keywords:

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

958-65

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(05)02779-2

journal_volume

84

pub_type

杂志文章

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