Abstract:
OBJECTIVE:To recover natural fertility of ewes that were subjected to ovarian failure induced by radiotherapy with an autologous orthotopic graft of cryopreserved germinative tissue. DESIGN:Experimental surgery study. SETTING:University hospital unit. ANIMAL(S):Adult ewes. INTERVENTION(S):Four ewes were submitted to right oophorectomy and posterior dissecting and freezing of the germinative tissue. Afterward, they were administered radiotherapy to induce infertility on the remaining left ovary. Later, two of the ewes had the thawed fragments of the right ovary injected inside the cortex of the irradiated left ovary in a "sowing" procedure that eliminated the need for sutures. MAIN OUTCOME MEASURE(S):Recovery of fertility in ewes after transplantation of germinative tissue into the ovary destroyed by radiotherapy. RESULT(S):The ewes were housed with fertile rams. Six months following the grafting, the rams impregnated the transplanted ewes. More than 2 years after radiotherapy, the nongrafted (control) ewes have not become pregnant. CONCLUSION(S):Intracortical grafting of the germinative tissue circumvents the obstacle of vascular anastomosis with autologous ovarian implants. Patients could benefit from the subcortical grafting of germinative tissue in one of the ovaries, recovering fertility after radiotherapy treatment for malignancy.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Almodin CG,Minguetti-Câmara VC,Meister H,Ceschin AP,Kriger E,Ferreira JOdoi
10.1016/j.fertnstert.2003.05.023keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
160-4issue
1eissn
0015-0282issn
1556-5653pii
S0015028203022854journal_volume
81pub_type
杂志文章abstract:OBJECTIVE:To assess the effects of estro-progestin supplementation on ghrelin-mediated GH release, we studied the consequence of ghrelin or saline injection before and after 60 days of hormone therapy or placebo administration in postmenopausal subjects. DESIGN:A prospective double blind, placebo-controlled, and paral...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2007.02.042
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of transforming growth factor (TGF)-beta1 on the extracellular signal-regulated kinase (ERK) and Smad pathway and the role of peroxisome proliferator-activated receptor (PPAR)-gamma in cultured human endometrial stromal cells. DESIGN:Experimental study. SETTING:Infertility center o...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.09.010
更新日期:2008-10-01 00:00:00
abstract::Two women with the polycystic ovary syndrome were treated with bromocriptine (15 to 20 mg/day) in combination with spironolactone (100 mg/day). In the first woman the combined therapy induced a marked reduction of hirsutism, with ensuing ovulation and pregnancy. In the second woman, who had hyperthecosis and had been ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)45554-8
更新日期:1981-06-01 00:00:00
abstract:OBJECTIVE:To determine the influence of ejaculatory abstinence on within-subject semen parameters and DNA fragmentation. DESIGN:Prospective study. SETTING:Private infertility institute and university-based research laboratory. PATIENT(S):Sixteen consenting male volunteers undergoing infertility investigation. INTER...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2004.03.014
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:To describe the prevalence of antiphospholipid antibodies to both anionic and zwitterionic phospholipids in women with early recurrent pregnancy losses (RPLs). DESIGN:Retrospective data analysis. SETTING:Tokai University Hospital, Kanagawa, Japan. PATIENT(S):One hundred thirty-nine patients with unexplaine...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(99)00119-3
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:To study birth outcomes among live born infants conceived by women who used infertility treatment. DESIGN:Population-based surveillance of women who recently delivered a live infant. SETTING:The birth outcomes among infants whose mothers used assisted reproductive technology (ART) or ovulation stimulation m...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究
doi:10.1016/j.fertnstert.2011.05.073
更新日期:2011-08-01 00:00:00
abstract::A number of patients who have involuntary infertility show sperm antibodies in the blood serum, as detected by two quite different methods of spermagglutination. These techniques are the Kibrick method (gelatin agglutination test) and the F-D method (tube-slide agglutination test). By the former technique, the sera of...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)43158-4
更新日期:1978-03-01 00:00:00
abstract:OBJECTIVE:Potential reparation of sperm DNA fragmentation in the oocyte may disturb any relationship between DNA-damaged sperm and the implantation ability of resulting embryos. To rule out this factor, we analyzed the consequences of sperm DNA fragmentation on IVF-ET outcome in women with healthy ovarian function. DE...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/j.fertnstert.2007.02.022
更新日期:2008-01-01 00:00:00
abstract::The immune system plays a critical role in pregnancy establishment and maintenance, but application of immunological principles to the treatment of infertility and pregnancy loss has had a checkered past. Improving knowledge in this area holds great promise for improving the treatment of subfertile patients. ...
journal_title:Fertility and sterility
pub_type:
doi:10.1016/j.fertnstert.2016.07.1090
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:To report a novel technique for cervical reconstruction in a patient with congenital agenesis of the cervix. DESIGN:Case report. SETTING:University-based tertiary care hospital. PATIENT(S):A woman with congenital absence of the cervix, functional vagina, and adenomyosis uteri. INTERVENTION(S):Laparoscopic...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.02.007
更新日期:2011-06-01 00:00:00
abstract::Mild-stimulation protocols with in vitro fertilization (IVF) generally aim to use less medication than conventional IVF. This guideline evaluates pregnancy and live-birth rates in patients expected to be poor responders using mild ovarian stimulation and natural-cycle protocols vs conventional IVF. ...
journal_title:Fertility and sterility
pub_type: 杂志文章,实务指引
doi:10.1016/j.fertnstert.2018.03.019
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:To compare the semen quality and hormonal status between patients with testicular cancer and normal versus increased serum levels of beta-hCG. DESIGN:Retrospective study. SETTING:Academic research environment. PATIENT(S):All 203 patients with testicular cancer who required chemotherapy in the period 1995-2...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.03.016
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:To determine the hormonal characteristics of a fecund menstrual cycle. DESIGN:Prospective observational study. SETTING:Clinical research center. PATIENT(S):Fourteen patients having artificial insemination with donor semen provided daily blood and urine samples in a nonconceptive cycle and the consecutive c...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(00)01765-9
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVE:To investigate whether antiphospholipid and related autoantibodies are associated with IVF implantation failure as well as with recurrent spontaneous miscarriage. DESIGN:Prevalence study. SETTING:University teaching hospital and associated IVF unit. PATIENT(S):Patients with at least three consecutive first...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(98)00312-4
更新日期:1998-11-01 00:00:00
abstract::The rapid postpartum return of gonadotropic function during bromocriptine treatment was investigated through hormonal measurements in 15 women. Luteinizing hormone (LH) was measured by a novel and specific assay that does not cross-react with human chorionic gonadotropin (hCG). Prolactin was effectively suppressed by ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60610-6
更新日期:1989-04-01 00:00:00
abstract:OBJECTIVE:To report a case of a gonadotroph adenoma diagnosed after a dramatic increase in estradiol level and ovarian hyperstimulation in response to a gonadotropin-releasing hormone agonist. DESIGN:Case report. SETTING:Outpatient practice and university hospital. PATIENT(S):A 35-year-old woman who presented with i...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(02)04342-x
更新日期:2002-12-01 00:00:00
abstract::This study, which is concerned with establishing clinically relevant corridors defining normal progesterone (P) levels in saliva, has addressed some of the shortcomings associated with previous equivalent studies (e.g., limited data, inadequately monitored ovulations, inadequately defined subjects). A sensitive, direc...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60366-7
更新日期:1988-12-01 00:00:00
abstract::Postmenopausal women treated with an isopropanolic extract of Cimicifuga racemosa underwent a decrease in the urinary concentration of N-telopeptides, a marker of bone resorption, and an increase in alkaline phosphatase, a marker of bone formation, at the third month of therapy. Serum from treated women did not modify...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.03.042
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To review current knowledge regarding recombinant DNA technology and its safety and efficacy in relation to recombinant gonadotropin production. DATA IDENTIFICATION AND SELECTION:Studies that relate specifically to recombinant DNA technology, method of laboratory production, and the clinical aspects of using...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/s0015-0282(16)58437-4
更新日期:1996-08-01 00:00:00
abstract::Laparoscopic sterilization was performed on 50 racially distributed patients, aged 18-42 years, who were selected at random from the Outpatient Laparoscope Sterilization Clinic and offered sterilization under local anesthesia. The patients were injected with a systemic analgesic as well as a local anesthetic. One in...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)38530-2
更新日期:1971-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the influence of socioeconomic factors on the outcomes of infertility, including pregnancy, adoption, resolution, and loss to follow-up. DESIGN:Prospective observational study. SETTING:Infertility clinics in 11 teaching hospitals. PATIENTS:Newly registered couples with infertility of > 1 year. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVE:To report a case of monochorionic, diamniotic twin pregnancy diagnosed at 6 weeks of pregnancy with three-dimensional (3D) transvaginal sonography and to discuss the use of this diagnostic method in the evaluation of multifetal pregnancy in the first trimester. DESIGN:Case report. SETTING:University-based I...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(99)00132-6
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:To determine the genetic cause of primary amenorrhea. DESIGN:Case series. SETTING:Pediatric endocrinology, endocrinology, and gynecology departments of academic hospitals. PATIENT(S):Three adolescents and one young woman 46, XY patients with srd5A2 gene mutations. MAIN OUTCOME MEASURE(S):Genetic analysis ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.08.007
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:To identify the gene(s) involved in the etiology of premature ovarian insufficiency in a highly consanguineous Tunisian family. DESIGN:Genetic analysis of a large consanguineous family with several affected siblings. SETTING:University hospital-based cytogenetics and molecular genetics laboratories. PATIEN...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2017.07.015
更新日期:2017-10-01 00:00:00
abstract::The proportions of good, fair, and poor embryos in 13 women with bilateral endometriomas were compared with those of 39 women without endometriomas and were found to be similar (47.2% vs. 41.1%, 28.3% vs. 32.8%, and 24.3% vs. 26.0%, respectively). Therefore, it appears that the presence of bilateral endometriomas duri...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.03.002
更新日期:2011-06-30 00:00:00
abstract::Fifteen subfertile males with absent or atrophic right testes underwent ligation of left varicoceles. Sperm concentration rose significantly with correction of scrotal thermographic abnormality and nine wives (60%) became pregnant. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55098-5
更新日期:1992-06-01 00:00:00
abstract:OBJECTIVE:To evaluate basal (constitutive) and stimulated synthesis of tumor necrosis factor alpha (TNF alpha), interleukin (IL)-8, IL-10 by peritoneal macrophages (PM) in women with endometriosis. DESIGN:Peritoneal macrophages were cultured in the presence or absence of lipopolysaccharide (LPS) for 24 hours. Peritone...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVE:To confirm the advantages of goserelin prior to endometrial ablation for the treatment of dysfunctional uterine bleeding. DESIGN:Multicenter, prospective, randomized, double-blind study. PATIENT(S):Cycling premenopausal women with dysfunctional uterine bleeding. TREATMENT:Patients were randomized to gosere...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1997-07-01 00:00:00
abstract:OBJECTIVE:To study differences between robotic and laparoscopic approach in Essure device removal. DESIGN:Demonstration video of two different surgical approaches. SETTING:Clinico San Carlos University Hospital in Madrid, Spain. PATIENT(S):A total of 737 Essure devices were implanted until June 2017 in Clinico San C...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2020.03.025
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:To investigate the prevalence and potential causes of reverse cleavage (RC) by human early-cleavage embryos and its associations with embryonic development and implantation after transfer. DESIGN:Clinical retrospective cohort study. SETTING:Private fertility treatment center. PATIENT(S):A total of 126 cons...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2014.07.1235
更新日期:2014-11-01 00:00:00