Semen quality in men with disseminated testicular cancer: relation with human chorionic gonadotropin beta-subunit and pituitary gonadal hormones.

Abstract:

OBJECTIVE:To compare the semen quality and hormonal status between patients with testicular cancer and normal versus increased serum levels of beta-hCG. DESIGN:Retrospective study. SETTING:Academic research environment. PATIENT(S):All 203 patients with testicular cancer who required chemotherapy in the period 1995-2003 were included. INTERVENTION(S):In 107 patients semen samples were stored by cryopreservation; 62 patients could be analyzed because both semen was stored and hormones were determined before starting chemotherapy (median age 25 years, range 17-49 years). MAIN OUTCOME MEASURE(S):Total motile sperm count, T, E(2), LH, FSH, and PRL. RESULT(S):Total motile sperm count was decreased in patients with increased beta-hCG (median 11.9 x 10(6)) compared with patients with normal beta-hCG (median 21.5 x 10(6)). Testosterone, E(2), and PRL were significantly higher in patients with increased beta-hCG levels, whereas LH and FSH were lower. Semen quality was significantly and negatively correlated with beta-hCG, E(2), and PRL. CONCLUSION(S):Patients with increased beta-hCG had an inferior spermatogenesis compared with patients with normal beta-hCG. Increased beta-hCG appears to be associated with impaired spermatogenesis and increased levels of E(2) and PRL.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

de Bruin D,de Jong IJ,Arts EG,Nuver J,Dullaart RP,Sluiter WJ,Hoekstra HJ,Sleijfer DT,Gietema JA

doi

10.1016/j.fertnstert.2008.03.016

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

2481-6

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(08)00587-6

journal_volume

91

pub_type

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