Differences in hormonal characteristics of conceptive versus nonconceptive menstrual cycles.

Abstract:

OBJECTIVE:To determine the hormonal characteristics of a fecund menstrual cycle. DESIGN:Prospective observational study. SETTING:Clinical research center. PATIENT(S):Fourteen patients having artificial insemination with donor semen provided daily blood and urine samples in a nonconceptive cycle and the consecutive conceptive cycle. INTERVENTION(S):Concentrations of E2, luteinizing hormone, follicle-stimulating hormone (FSH), and P4 were measured in serum. Urine samples were analyzed for metabolites of E2, P4, and FSH. MAIN OUTCOME MEASURE(S):The serum and urinary hormone profiles of the periovulatory period were compared in conceptive and nonconceptive cycles. RESULT(S):The mean peak value of periovulatory urinary FSH was significantly higher in conceptive cycles than in nonconceptive cycles. The mean serum E2 concentration was significantly higher on day 0 (day of peak urinary FSH concentration) in conceptive cycles than in nonconceptive cycles, but mean peak values of serum E2 did not differ significantly. No other significant differences were observed in serum and urinary hormone profiles between conceptive and nonconceptive cycles. CONCLUSION(S):A lower, broader peak of FSH in urine was observed in nonconceptive cycles compared with conceptive cycles. Urinary FSH measurements may be useful in predicting less fecund ovulatory cycles and may identify some types of reduced female fertility.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Li H,Nakajima ST,Chen J,Todd HE,Overstreet JW,Lasley BL

doi

10.1016/s0015-0282(00)01765-9

keywords:

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

549-53

issue

3

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(00)01765-9

journal_volume

75

pub_type

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