Abstract：
OBJECTIVE:To report a live birth of twins from autologous zona-free oocytes. DESIGN:Case report. SETTING:Reproductive endocrinology and infertility private practice and ambulatory in vitro fertilization (IVF) center. PATIENT(S):A 34-year-old woman, gravida 0, with 100% zona-free oocytes. INTERVENTION(S):IVF with intracytoplasmic sperm injection (ICSI), blastocyst culture, and fresh embryo transfer. MAIN OUTCOME MEASURE(S):Fertilization, blastocyst development, and live birth. RESULT(S):A 34-year-old woman, gravida 0, conceived through IVF using autologous zona-free oocytes. The 11 retrieved oocytes were zona-free, from which eight were inseminated with ICSI; two embryos were transferred at morula and blastocyst stage, resulting in a twin pregnancy delivered at an estimated the gestational age of 37 weeks and 1 day. CONCLUSION(S):Patients with the rare condition of 100% zona-free oocytes maintain the potential for pregnancy after careful micromanipulation of the oocytes. Caution is recommended on the number of embryos selected for transfer to reduce the risk of multiple gestation.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Hu Y,Trolice MPdoi
10.1016/j.fertnstert.2016.01.023subject
Has Abstractpub_date
2016-05-01 00:00:00pages
1232-1235issue
5eissn
0015-0282issn
1556-5653pii
S0015-0282(16)00064-9journal_volume
105pub_type
杂志文章abstract：:Intrafollicular insemination is a promising new development that may have a major impact on ART, notably in the treatment of male factor infertility. Reported is the first successful intrafollicular insemination in the United States and the first successful intrafollicular insemination for male factor infertility. Alt...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)55191-7
更新日期：1992-08-01 00:00:00
abstract：OBJECTIVE:To compare pathologic characteristics and epidemiologic risk factors for uterine fibroids in African American and white women undergoing hysterectomy. DESIGN:Cross-sectional analysis of women undergoing premenopausal hysterectomy. SETTING:Two university-associated hospitals in North Carolina. PATIENT(S):Af...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2012.10.039
更新日期：2013-03-01 00:00:00
abstract：OBJECTIVE:To determine whether polymorphisms in the estrogen receptor (ER) alpha and beta genes are associated with endometriosis in a Japanese population. DESIGN:Association study. SETTING:University hospital. PATIENT(S):Japanese women diagnosed with endometriosis by laparotomy or laparoscopy. INTERVENTION(S):Dete...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.02.094
更新日期：2004-06-01 00:00:00
abstract：OBJECTIVE:To study the possible presence of extracellular superoxide anion (O2-) in untreated semen of normal and pathological subjects and to determine the possible relationship between superoxide anion levels, number of seminal leukocytes (WBCs) and seminal parameters. PATIENTS:Semen samples were analyzed from ferti...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)57017-4
更新日期：1994-10-01 00:00:00
abstract：OBJECTIVE:To study the messenger ribonucleic acid (mRNA) expression of receptors for insulin, insulin-like growth factor I (IGF-I), and insulin-like growth factor II (IGF-II) in human fetal ovaries and uteri at 10, 15, 19, and 22 weeks' gestation. Insulin, IGF-I, and IGF-II are postulated to have paracrine and autocrin...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)55924-x
更新日期：1993-05-01 00:00:00
abstract：OBJECTIVE:To investigate the relationship between growth hormone (GH) and luteal function. DESIGN:In vivo comparative and in vitro culture studies. SETTING:University hospital. PATIENT(S):Eighteen women who were interested in becoming pregnant and visited our clinic voluntarily participated in the study for urinary ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.07.1304
更新日期：2008-09-01 00:00:00
abstract：:Our studies demonstrate significantly lower expression of relaxin and its receptor in ectopic endometriotic tissues than their expression in eutopic endometrium and in endometrium from normal controls. These data suggest that in normal and eutopic endometrium, relaxin may exert a protective effect against endometriosi...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.06.051
更新日期：2010-12-01 00:00:00
abstract：:We found that there was no significant difference in endometrial responses to vaginal or IM P. But the response was suboptimal in cycles treated with dydrogesterone, suggesting that dydrogesterone treatment is not the preferred progestin for use in artificial cycles. ...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(16)56840-x
更新日期：1994-07-01 00:00:00
abstract：:This study was initiated to determine whether factors are present in human sperm-free seminal plasma (HSP) that regulate the uptake and release of carnitine from sperm. Bovine caput epididymal sperm cells accumulated more carnitine than caudal sperm cells. A significant reduction in carnitine uptake by caput sperm was...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1988-05-01 00:00:00
abstract：OBJECTIVE:To compare the efficacy and side effects of vaginal misoprostol with dinoprostone for cervical priming before operative hysteroscopy and to assess the cervicouterine complications related to cervical dilatation and hysteroscopic surgery. DESIGN:A prospective randomized study. SETTING:Tertiary university hos...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2006.03.039
更新日期：2006-10-01 00:00:00
abstract：:There is good evidence of an associated abnormality in testicular hormone production and spermatogenesis in some men with varicoceles. This abnormality can be demonstrated with dynamic tests of the hypothalamic-pituitary-testicular axis and by measuring seminal plasma androgen levels. A high proportion of oligozoosper...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/s0015-0282(16)59700-3
更新日期：1988-02-01 00:00:00
abstract：OBJECTIVE:To study the ovarian reserve, ovarian response to gonadotropins, and oocyte maturity in women with cancer undergoing in vitro fertilization (IVF) before chemotherapy or radiotherapy. DESIGN:Case-control study. SETTING:University teaching hospital. PATIENT(S):We evaluated all women with malignancy who under...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.04.070
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVE:To determine if estrogen ameliorates hot flashes by raising the core body temperature sweating threshold, by reducing core body temperature fluctuations, and/or by reducing sympathetic activation (as measured by plasma 3-methoxy-4-hydroxyphenylglycol). DESIGN:Laboratory physiological study. SETTING:Universi...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(01)03009-6
更新日期：2002-03-01 00:00:00
abstract：OBJECTIVE:To determine the prevalence of idiopathic hirsutism among a population of consecutive hirsute patients. DESIGN:Prospective cohort study. SETTING:University-based clinic. PATIENT(S):Premenopausal women with a complaint of hirsutism who were not receiving hormonal therapy. INTERVENTION(S):Evaluations for to...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(98)00141-1
更新日期：1998-08-01 00:00:00
abstract：:Two groups of normal ovulatory women who displayed either a marked (high responders; HR) or a more subtle (low responders; LR) ovarian response to a fixed dose of human menopausal gonadotropins (hMG) were evaluated for differences in blood levels of hormones. Serum follicle-stimulating hormone (FSH) levels doubled dur...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)49632-9
更新日期：1986-10-01 00:00:00
abstract：OBJECTIVE:To determine the feasibility of performing in vivo magnetic resonance elastography (MRE) for uterine leiomyoma. DESIGN:Pilot study. SETTING:Academic medical center. PATIENT(S):Six subjects planning surgical excision of uterine leiomyomas. INTERVENTION(S):MRE before planned surgery. MAIN OUTCOME MEASURE(S...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/j.fertnstert.2010.06.004
更新日期：2011-01-01 00:00:00
abstract：:Certain conclusions may be drawn from the present review and presentation of new data concerning the unilaterally cryptorchid patient and possible subfertility: 1. The truly undescended testis--not the retractile testis of infancy--will not descend spontaneously after 1 year of age. 2. The seminal quality of the unila...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)41889-3
更新日期：1976-06-01 00:00:00
abstract：OBJECTIVE:To compare sperm characteristics among: patients undergoing infertility evaluation, patients with male factor infertility (MFI), healthy sperm donors, and men with proven fertility; to examine the overlap of sperm characteristics in all four of these groups; and to identify good discriminators of fertility ve...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2005.08.024
更新日期：2006-03-01 00:00:00
abstract：:The usefulness of a short-interval second-look laparoscopy (SLL) after ovarian surgery was examined. In 23 infertile women who had either bilateral wedge resection (BWR) of polycystic ovaries, an oophorocystectomy (OC), or resection of endometriomata (RE), adhesions were graded before and after surgery and before and ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)48975-2
更新日期：1985-11-01 00:00:00
abstract：OBJECTIVE:To evaluate whether overweight and obesity are related to changes in serum sex hormone concentrations and semen quality. DESIGN:Cross-sectional study. SETTING:Data from five previous population-based environmental studies of semen quality were combined into one database at a university hospital in Denmark. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.07.1292
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVE:To ascertain whether obstetric, gynecologic, or congenital variables affect implantation efficiency or eventual delivery in donor oocyte recipients. DESIGN:Clinical study. SETTING:Academic tertiary care infertility clinic. PATIENT(S):A total of 370 recipients. INTERVENTION(S):Fresh ET following oocyte don...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(98)00420-8
更新日期：1999-01-01 00:00:00
abstract：OBJECTIVE:To determine whether there is an association between abnormal semen parameters and occupational exposures to organic solvents, metals, and pesticides. DESIGN:Case-control study using three case groups based on different cutoff values for semen parameters and one standard reference group. SETTING:University ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(98)00542-1
更新日期：1999-04-01 00:00:00
abstract：OBJECTIVE:To measure autoantibodies that recognize oxidatively modified proteins in the sera of women with surgically proven endometriosis. DESIGN:Prospective study. SETTING:Tertiary care academic medical center. PATIENT(S):Women undergoing surgery for endometriosis or tubal ligation. INTERVENTION(S):None. MAIN OU...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(99)00145-4
更新日期：1999-06-01 00:00:00
abstract：OBJECTIVE:To assess the relationship between history of surgery for endometriosis and adverse obstetrical outcomes. DESIGN:Retrospective study using prospectively recorded data. SETTING:Referral center. PATIENT(S):Total of 569 women with history of surgery for endometriosis, postoperative conception, and pregnancy e...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2019.12.037
更新日期：2020-05-01 00:00:00
abstract：:Characterization of the implanting human fetus as an allograft prompted a field of research in reproductive immunology that continues to fascinate and perplex scientists. Paternal- or partner-derived alloantigens are present in the maternal host at multiple times during the reproductive process. They begin with exposu...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2016.07.1073
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVE:To investigate the localization of tenascin expression in the endometrium of women without endometriosis and in endometriotic implants, and to determine the in vitro regulation of tenascin by E(2) in these tissues. DESIGN:Experimental laboratory study. SETTING:University medical center. PATIENT(S):Reproduc...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.05.028
更新日期：2008-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the occurrence of microdeletions of the Y chromosome involving the DAZ and YRRM genes in patients with Klinefelter's syndrome with and without spermatogenesis. DESIGN:Controlled clinical study. SETTING:Yamagata University Hospital, Yamagata, Japan. PATIENT(S):Patients with Klinefelter's syndrom...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(98)00546-9
更新日期：1999-04-01 00:00:00
abstract：OBJECTIVE:To demonstrate the laparoscopic neuroanatomy of the autonomic nerves of the pelvis using the laparoscopic neuronavigation technique, as well as the technique for a nerve-sparing radical endometriosis surgery. DESIGN:Step-by-step explanation of the technique using videos and pictures (educational video) to de...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2015.07.1138
更新日期：2015-11-01 00:00:00
abstract：:Based on American Society for Reproductive Medicine (ASRM) and Society for Assisted Reproductive Technology data available for 2010, ASRM's guidelines for the number of embryos to be transferred in in vitro fertilization cycles have been further refined in continuing efforts to reduce the number of higher-order multip...
journal_title：Fertility and sterility
pub_type： 杂志文章,实务指引
doi：10.1016/j.fertnstert.2012.09.038
更新日期：2013-01-01 00:00:00
abstract：:Collagenolytic enzyme activities presumed to play an important role in ovulation were investigated in the human follicular apex, base, and granulosa cell layer throughout the ovarian cycle. Those analyzed were human ovarian collagenase, 2,4-dinitrophenyl-Pro-Gln-Gly-Ile-Ala-Gly-Gln-D-Arg-OH peptidase, N-carbobenzoxy-G...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)45920-0
更新日期：1981-12-01 00:00:00
