A factor in human seminal plasma which affects carnitine accumulation in bovine epididymal sperm.

Abstract:

:This study was initiated to determine whether factors are present in human sperm-free seminal plasma (HSP) that regulate the uptake and release of carnitine from sperm. Bovine caput epididymal sperm cells accumulated more carnitine than caudal sperm cells. A significant reduction in carnitine uptake by caput sperm was observed in the presence of HSP from normal subjects, but not from three subjects with reduced motility. A factor has been isolated from HSP that inhibits carnitine uptake by caput sperm and has the following properties: it is nondialyzable, stable to freeze-thawing, soluble in 60% ammonium sulfate, and has an approximate molecular weight of 158 kd. These data are consistent with the existence of a relatively high molecular weight protein in HSP responsible for the preservation of carnitine concentrations in sperm.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Carter AL,Cho SH,Bishop ER,Boldt J

subject

Has Abstract

pub_date

1988-05-01 00:00:00

pages

893-9

issue

5

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)59903-8

journal_volume

49

pub_type

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