Abstract：
OBJECTIVE:To investigate whether an association exists between ovulation induction and neural tube defects (NTDs). MATERIALS AND METHODS:Risk estimations in the medical literature were identified through Medline, and validity and power were assessed. Large in vitro fertilization-embryo transfer (IVF-ET) registries represent another source of information. The total number of NTDs and the total number of fetuses were computed from five registries. These data were expressed as proportions and compared with data from the general population. RESULTS:Only one study could be identified as both valid and powerful, through literature review. This case-control study concluded there was no association between ovulation induction and NTDs. The pool of IVF-ET registry data represents another powerful epidemiologic tool. Analysis of the registry data confirms the findings of the case-control study. CONCLUSIONS:Ovulation induction does not seem to represent a risk factor for NTDs in the offspring.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Van Loon K,Besseghir K,Eshkol Adoi
10.1016/s0015-0282(16)55428-4keywords:
subject
Has Abstractpub_date
1992-11-01 00:00:00pages
875-84issue
5eissn
0015-0282issn
1556-5653pii
S0015-0282(16)55428-4journal_volume
58pub_type
杂志文章,评审abstract：:Buserelin acetate, a luteinizing hormone-releasing hormone agonist, is known to be effective in the shrinkage of uterine fibroids. A prospective trial was undertaken (1) to compare the efficacy of intranasal (IN) and subcutaneous (SC) administration of buserelin acetate and (2) to assess if tumor regression correlated...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(16)54001-1
更新日期：1990-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the efficacy of reoperation for stage III or IV endometriosis-related infertility versus IVF-ET. DESIGN:Retrospective analysis. SETTING:In vitro fertilization-embryo transfer unit and tertiary infertility clinic. PATIENTS:Twenty-three couples with stage III or IV endometriosis-related infertili...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/s0015-0282(16)58215-6
更新日期：1996-04-01 00:00:00
abstract：:In vitro fertilization and embryo transfer (IVF-ET) and gamete intrafallopian transfer (GIFT) are used to treat intractable infertility in women with no distortion of the pelvic viscera, despite the lack of controlled trials demonstrating efficacy. The mechanism of any purportedly enhanced cycle fecundity in ovulatory...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)59414-x
更新日期：1987-09-01 00:00:00
abstract：STUDY OBJECTIVE:To evaluate the prognostic and therapeutic value of a Lupron (leuprolide acetate; Tap Pharmaceuticals, North Chicago, IL) screening test before ovarian stimulation for in vitro fertilization (IVF). DESIGN:Prospective. SETTING:Outpatient IVF program. PATIENTS:Eighty patients exhibited four early estra...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(16)54421-5
更新日期：1991-07-01 00:00:00
abstract：OBJECTIVE:To determine the effect of sodium alginate encapsulation of rodent embryos on in vitro embryonic cleavage rates, implantation rates, and livebirth rates, and to find the in vivo degradation time for the capsules. DESIGN:Studies were conducted using both CB6F1 mice and Golden Syrian hamsters. RESULTS:Capsule...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)55814-2
更新日期：1993-03-01 00:00:00
abstract：OBJECTIVE:To provide an up-to-date comprehensive review of published data on laparoscopic methods of ovulation induction in the polycystic ovary syndrome (PCOS). Areas to be considered include the historical background of these procedures, their outcomes as reported in the literature, and their potential adverse effect...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/s0015-0282(16)57408-1
更新日期：1995-03-01 00:00:00
abstract：OBJECTIVE:To test the hypothesis that oligo-ovulatory ovulation is associated with hyperandrogenemia in the absence of other clinical signs of androgen excess. DESIGN:Retrospective cohort controlled. SETTING:Tertiary care university-based outpatient clinic. PATIENT(S):Thirty-two consecutive nonhirsute oligo-ovulator...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)80089-1
更新日期：1997-03-01 00:00:00
abstract：OBJECTIVE:To explore the role of tumor necrosis factor (TNF) α, an early embryonic product, on endometrial epithelial cell migration and endometrial milk fat globule-epidermal growth factor 8 protein (MFG-E8) production. DESIGN:In vitro study. SETTING:Academic center. INTERVENTION(S):Ishikawa cells, used as surrogat...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.10.032
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVE:To survey the level of disclosure of conception method within families of children conceived by conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) and to examine the factors that might influence parental attitudes and plans for disclosure. DESIGN:In-depth questionnaire. SET...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.12.019
更新日期：2005-04-01 00:00:00
abstract：OBJECTIVE:To assess the efficacy of tibolone add-back therapy with Goserelin treatment of uterine fibroids. DESIGN:Randomized placebo-controlled study. SETTING:Gynecology department of an inner-city teaching hospital. PATIENT(S):Seventy-five women of reproductive age with uterine fibroids. INTERVENTION(S):All women...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2007.02.064
更新日期：2008-02-01 00:00:00
abstract：:Discrepancies about a possible relationship between prothrombotic mutations and a decreased uteroplacental blood flow are present in literature. We prospectively evaluated a cohort of pregnant women (n = 41) with bilateral uterine artery notches and found that women with inherited thrombophilia showed a sixfold higher...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.01.038
更新日期：2006-09-01 00:00:00
abstract：OBJECTIVE:To determine whether luteal phase defect (LPD) may be an etiologic factor in ectopic pregnancy (EP). DESIGN:All patients who were seen over a 6-year period with the chief complaint of infertility underwent an extensive infertility workup and were followed prospectively. The diagnoses of the causes of inferti...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)57292-6
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the rate of postoperative complications between conservative surgery and segmental resection in patients with rectal endometriosis. DESIGN:Single-center retrospective study. SETTING:University hospital. PATIENT(S):A total of 232 women undergoing surgery for deep endometriosis infiltrating the r...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2020.02.108
更新日期：2020-06-01 00:00:00
abstract：:The aim of the present study was to compare the levels of leukemia inhibitory factor (LIF) in the tubal ampullary region in normal and ectopic pregnancies and assess possible causative role of LIF in ectopic pregnancy. Although there was a tendency of increase in LIF concentrations in the ectopic pregnancy group, we w...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.09.014
更新日期：2005-02-01 00:00:00
abstract：OBJECTIVE:To review our experience with low-dose IM methotrexate for the medical management of ectopic pregnancy (EP). DESIGN:Retrospective chart review. SETTING:Magee-Womens Hospital, Pittsburgh, Pennsylvania. PATIENT(S):The first 50 women treated by the resident service in whom EP was diagnosed and treated with me...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)00284-7
更新日期：1997-10-01 00:00:00
abstract：:Constant infusion of gonadotropin-releasing hormone agonist (GnRH-A) in the rhesus monkey leads to far greater suppression of spermatogenesis than its intermittent administration. To assess whether administration of GnRH-A by constant subcutaneous infusion will also lead to greater inhibition of gonadal function, we a...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)48684-x
更新日期：1985-07-01 00:00:00
abstract：:Women with classic congenital adrenal hyperplasia (CAH) can suffer from impaired fertility rates as a result of increased androgen secretion or impaired sex steroid production. In virilizing CAH forms, such as 21-hydroxylase and 11β-hydroxylase deficiency, the low reported pregnancy rate is mainly secondary to a dimin...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2018.11.037
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:To report the case of an infertile female patient with cystic fibrosis who was diagnosed with endocervical metaplasia of the endometrium at diagnostic hysteroscopy and successfully treated with an oral estroprogestinic formulation. DESIGN:Case report. SETTING:University hospital. PATIENT(S):A 27-year-old i...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2005.07.1336
更新日期：2006-03-01 00:00:00
abstract：:Predictors of weight at resumption of menses were studied in 118 subjects with lifetime anorexia nervosa who recovered their ovarian function without hormonal therapies. About 64% of subjects had menses resumption during spring/summer season. The body mass index (BMI) at resumption of menses was significantly predicte...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.04.055
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:To determine association between health-related quality of life (HRQOL) and psychosexual variables in patients with polycystic ovary syndrome (PCOS). DESIGN:Cross-sectional study. SETTING:Two private gynecology clinics. PATIENT(S):A sample of 300 women with PCOS were entered into the study and were subdivi...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2013.06.043
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:To report the case of a female who presented in childhood with symptoms and signs of hyperandrogenism secondary to an extraovarian steroid cell tumor. DESIGN:Case report. SETTING:Endocrine investigation unit of a university teaching hospital. PATIENT(S):An 11-year-old female presented with symptoms and sig...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2005.06.055
更新日期：2006-01-01 00:00:00
abstract：:Eight castrate, estrogen-replaced women were given 200 mg spironolactone daily for 4 weeks. The response of plasma dehydroepiandrosterone sulfate (DHEAS), testosterone (T), and androstenedione (delta 4A), all indicators of adrenal C19-steroid production, varied greatly among individuals. Sixteen women with idiopathic ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)59346-7
更新日期：1987-08-01 00:00:00
abstract：OBJECTIVE:To describe the first case of delivery after the transfer of a single blastocyst derived from a vitrified mature human oocyte. DESIGN:Case report. SETTING:Private assisted reproduction clinic. PATIENT(S):A normal 31-year-old woman. INTERVENTION(S):An unsuccessful attempt was made to extract sperm from the...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2005.04.051
更新日期：2005-10-01 00:00:00
abstract：OBJECTIVE:To show the responsiveness of tissue-engineered human endometrial stroma to combinations of hormones that mimic the secretory and menstrual phases of the cycle. DESIGN:In vitro experimental study. SETTING:University uterine biology research laboratory. PATIENT(S):None. INTERVENTION(S):Telomerase immortali...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2012.01.098
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:To evaluate the impact of female smoking on early embryo development in vitro using a time-lapse system. DESIGN:Retrospective analysis of prospectively collected database. SETTING:Assisted reproductive technology (ART) program. PATIENT(S):A total of 135 infertile couples undergoing IVF-intracytoplasmic spe...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.01.136
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVE:The pharmacokinetics of norelgestromin, the primary active metabolite of norgestimate, plus ethinyl estradiol (EE), delivered by the once-weekly contraceptive patch (Ortho Evra/Evra), have been studied in eight trials. This overview summarizes the relevant pharmacokinetic data for the contraceptive patch. DE...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/s0015-0282(01)03261-7
更新日期：2002-02-01 00:00:00
abstract：OBJECTIVE:To determine whether men with azoospermia are at an elevated risk of developing cancer in the years following an infertility evaluation. DESIGN:Cohort study. SETTING:United States andrology clinic. PATIENT(S):A total of 2,238 men with complete records were evaluated for infertility at a single andrology cl...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.05.022
更新日期：2013-09-01 00:00:00
abstract：OBJECTIVE:To investigate P secretion by granulosa cells (GCs) versus cumulus cells derived from human preovulatory follicles. DESIGN:Cells were recovered by aspiration of preovulatory follicles in 44 women participating in an IVF program. Induction of ovulation was performed using clomiphene citrate, hMG and hCG (grou...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)56404-8
更新日期：1993-12-01 00:00:00
abstract：OBJECTIVE:To review the rate, setting, and demographic characteristics of tubal sterilization and its current trend within contraceptive practice in the United States. DESIGN:Review of U.S. health care statistics, NCHS publications, English-language literature searched using MEDLINE and PubMed, and bibliographies of k...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2010.03.029
更新日期：2010-06-01 00:00:00
abstract：:A large body of research confirms the vulnerable nature of spermatogenesis to relatively small increases in testicular temperature. Other physical properties of electromagnetic and ultrasound waves have additive or synergistic effects to those of heat and allow disruption of spermatogenic processes at minimal tempera...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/s0015-0282(16)59640-x
更新日期：1988-01-01 00:00:00
