Abstract:
:In vitro fertilization and embryo transfer (IVF-ET) and gamete intrafallopian transfer (GIFT) are used to treat intractable infertility in women with no distortion of the pelvic viscera, despite the lack of controlled trials demonstrating efficacy. The mechanism of any purportedly enhanced cycle fecundity in ovulatory women without significant distortion of the pelvic viscera is unclear, but both GIFT and IVF-ET increase the number of male and female gametes at the site of fertilization. Intrauterine insemination (IUI) during human menopausal gonadotropin (hMG)-stimulated superovulatory cycles has similar potential but does not require oocyte retrieval. To evaluate the possibility that simply increasing the number of gametes at the site of fertilization might account for pregnancies attributed to IVF-ET and GIFT, the authors retrospectively analyzed the outcome of couples undergoing IUI during hMG cycles between 1983 and 1986 in women with normal pelvic anatomy. IUI during hMG-stimulated cycles yielded a cycle fecundity (f) of 0.17 for endometriosis, 0.29 for cervical factor, and 0.19 for idiopathic infertility, which approaches the fecundity of normal women and equals or exceeds that reported for IVF-ET and GIFT. The authors conclude that treatment with IUI in hMG cycles, alleviating the need for invasive oocyte retrieval, should be considered for inclusion in a randomized, controlled trial in comparison with IVF-ET and GIFT.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Dodson WC,Whitesides DB,Hughes CL Jr,Easley HA 3rd,Haney AFdoi
10.1016/s0015-0282(16)59414-xsubject
Has Abstractpub_date
1987-09-01 00:00:00pages
441-5issue
3eissn
0015-0282issn
1556-5653pii
S0015-0282(16)59414-Xjournal_volume
48pub_type
杂志文章abstract:OBJECTIVE:To describe a case of bilateral internal jugular vein thrombosis complicating ovarian hyperstimulation syndrome (OHSS). DESIGN:Case report. SETTING:Internal medicine ward in a teaching hospital. PATIENT:A 28-year-old nulliparous woman undergoing IVF. INTERVENTION(S):Ultrasonographic Doppler of the neck ve...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)00459-7
更新日期:1998-01-01 00:00:00
abstract::The aim of this work is to review the need for new diagnostic tools for sperm, the relevance of sperm mRNA in reproductive success, and the potential of a state-of-the-art microarray-based diagnostic tool for improving reproductive results. ...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2013.02.006
更新日期:2013-03-15 00:00:00
abstract:OBJECTIVE:To investigate the expression and localization of vitamin D(3) receptor (VDR) in reproductive organs of cycling mice. DESIGN:Experimental animal study. SETTING:Academic research center. ANIMAL(S):Mature (8 to 12 weeks old) cycling female Balb/c mice. INTERVENTION(S):Reproductive tissue, including endometr...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.09.045
更新日期:2010-05-15 00:00:00
abstract::Serum follicle-stimulating hormone (FSH) levels measured by radioimmunoassay (RIA) usually correlate well with the rate of spermatogenesis. However, in certain cases this correlation does not exist. The purpose of this study was to establish a reliable bioassay of FSH for the andrological clinic. Follicle-stimulating ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53469-4
更新日期:1990-04-01 00:00:00
abstract:OBJECTIVE:To investigate the expression pattern of proinflammatory, anti-inflammatory, and angiogenic cytokines and their effect on various mediators of endometrial receptivity in women with idiopathic recurrent spontaneous miscarriage (IRSM). DESIGN:A prospective study. SETTING:Tertiary care hospital and reproductiv...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.08.034
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To establish the relative frequency of aneuploidy in sperm from normal and abnormal subjects using dual color fluorescence in situ hybridization and probes for six different chromosomes. DESIGN:Semen from 33 normal males and a patient with a translocation was studied using dual color fluorescence in situ hyb...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)56896-4
更新日期:1994-08-01 00:00:00
abstract:OBJECTIVE:To investigate the direct actions of active 1,25-dihydroxy vitamin D3 (VD3) upon primate follicular development at specific stages of folliculogenesis. DESIGN:Secondary preantral follicles were isolated from rhesus monkeys ovaries, encapsulated in alginate, and cultured for 40 days. Follicles were randomly a...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2016.08.037
更新日期:2016-12-01 00:00:00
abstract::Asherman's syndrome is described in today's context. Meaningful literature as it relates to the description and management of this entity is reviewed, and the forms of treatment used at the Hospital of the University of Pennsylvania or at the Philadelphia General Hospital are presented. Asherman's syndrome describes...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)39918-6
更新日期:1973-09-01 00:00:00
abstract:OBJECTIVE:To study the correlation between genital phenotype and cystic fibrosis genotype in men lacking at least one vas deferens. DESIGN:Prospective study. SETTING:Institut Rhônalpin pour la Reproduction Humaine, Lyon-Bron, France. PATIENT(S):Forty-seven infertile men lacking at least one vas deferens. INTERVENTI...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(02)02954-0
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:To investigate whether abnormalities in serum concentrations of 1,25-dihydroxyvitamin D [1,25(OH)(2)D], 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), calcium, and phosphorus were associated with risk of polycystic ovary syndrome (PCOS) and obesity. The possible correlations of the calciotropic hor...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.11.031
更新日期:2010-03-01 00:00:00
abstract::Women with a BRCA mutation have unique concerns about childbearing and future fertility. In a focus group conducted among unaffected carriers, the majority of women held positive attitudes toward preimplantation genetic diagnosis to reduce transmission to future offspring and further identified unmet needs for educati...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.03.064
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:To measure IVF effectiveness, which is defined as the cumulative incidence of live delivery over real time in women after commencing IVF treatment. DESIGN:Population-based retrospective cohort study. SETTING:IVF clinics in Western Australia (WA). PATIENT(S):All women ages 20-44 years inclusive at start of ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.01.130
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To evaluate whether stimulation of endometrium embryo transfer (SEET) can improve implantation rate and pregnancy rate (PR) for patients undergoing assisted reproductive technology (ART) for the first time by injecting embryo culture supernatant into the uterus before blastocyst transfer (BT). DESIGN:Randomi...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2008.08.076
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:To investigate whether the embryotoxic effect of peritoneal fluid (PF) from infertile women with mild endometriosis on mouse oocytes and embryos is associated with changes in embryonic epidermal growth factor (EGF), insulin-like growth factor-I (IGF-I), and their receptors. DESIGN:Experimental animal study. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.11.011
更新日期:2010-05-15 00:00:00
abstract:OBJECTIVE:To investigate the use of preimplantation genetic diagnosis (PGD) as a method for increasing pregnancy success rates in patients at high risk for aneuploidy. DESIGN:Literature review and discussion of current evidence. CONCLUSION(S):Preimplantation genetic diagnosis selects euploid embryos for transfer in a...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2005.06.045
更新日期:2006-01-01 00:00:00
abstract::Cell proliferation of endometrial stromal cells treated with peritoneal fluid of women (aged 25 to 43 years) with endometriosis (n = 12) statistically significantly increased compared with the control treatment (peritoneal fluid of women without endometriosis, n = 8). Also, COX-2 gene expression and prostaglandin E(2)...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.11.039
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To determine the relative effectiveness of single vs. two transcervical monthly insertions of 252 mg of quinacrine for female sterilization. DESIGN:Controlled clinical study. SETTING:Family planning clinics of 6 academic centers. PATIENT(S):Sexually active reproductive-age women requesting sterilization. ...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0015-0282(02)02957-6
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:To determine the presence of M. genitalium and C. trachomatis in women attending fertility clinics and to follow these women for the effects of previous infections or tubal damage on pregnancy rate and outcome. DESIGN:Prospective study. SETTING:Fertility clinics and university. PATIENT(S):Two hundred twelv...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2006.12.056
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:To determine the influence of ejaculatory abstinence on within-subject semen parameters and DNA fragmentation. DESIGN:Prospective study. SETTING:Private infertility institute and university-based research laboratory. PATIENT(S):Sixteen consenting male volunteers undergoing infertility investigation. INTER...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2004.03.014
更新日期:2004-07-01 00:00:00
abstract::We have previously observed that preimplantation embryo biopsy in the mouse causes a reduction in implantation rate in utero. After minor modifications to the technique, we now find that sampling a single blastomere from the 4-cell mouse embryo does not compromise continued development in vitro or in vivo. When transf...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60564-2
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVE:To determine whether the oncofetal protein IMP3 is detectable in endometriomas with or without histological atypia and whether IMP3 staining can be used as a triage tool to identify foci of atypical endometriosis in doubtful cases. DESIGN:Retrospective study. SETTING:Academic department and referral center ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2013.02.002
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVES:To demonstrate the effectiveness of ultrarapid cryopreservation in human embryos. DESIGN:Retrospective study. SETTING:An IVF unit of a medical center. PATIENT(S):All cases received ultrarapid freezing (URF) of embryos and frozen embryo transfer. INTERVENTION(S):Embryos were placed in phosphate-buffered s...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(99)00257-5
更新日期:1999-08-01 00:00:00
abstract:OBJECTIVE:To determine if women who were randomized to a mind/body program before starting their first IVF cycle would have higher pregnancy rates than control subjects. DESIGN:Randomized, controlled, prospective study. SETTING:Private academically affiliated infertility center. PATIENT(S):A total of 143 women aged≤...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2011.03.046
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:To report the inheritance of a pericentric inversion in chromosome 7 through the three progenies, congenital hydronephrosis, and recurrent miscarriages in an extended family. DESIGN:Case report. SETTING:Medical Faculty of Cukurova University in Turkey. PATIENT(S):Referred by obstetrics and gynecology clini...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.02.030
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To examine the effect of supraphysiologic doses of testosterone (T) on plasma total homocysteine (tHcy) concentrations in patients with Klinefelter's syndrome (KS). DESIGN:Prospective clinical study. SETTING:University hospital. PATIENT(S):Thirty-two newly diagnosed male patients with KS, and 20 healthy, v...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2003.11.029
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:To define the hypersensitive status of PRL secretion in normoprolactinemic infertile women and determine the incidence of occult hyperprolactinemia among them. DESIGN:The potential for PRL secretion was examined in 463 women. SETTING:Outpatient clinic in a university hospital. PATIENTS:Three hundred sixty-...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)56154-8
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVE:Evaluate the effectiveness of a new ovarian stimulation (OS) protocol before IVF. DESIGN:Prospective clinical randomized trial. SETTING:Private centers. PATIENT(S):Three hundred and twenty-three intended-to-treat women candidates for IVF. INTERVENTION(S):Patients were divided into three groups and adminis...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2006.02.110
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVE:To investigate the possibility of genetic contribution of CYP1A1, CYP19, GSTM1, and GSTT1 polymorphisms to endometriosis. DESIGN:Genetic polymorphism analysis. SETTING:Case-control study. PATIENT(S):A group of 275 women with sporadic endometriosis was compared with a group of 346 fertile, endometriosis-fre...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(02)04817-3
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVE:To evaluate whether some ultrasound parameters of ovarian morphology can discriminate between control women and patients with polycystic ovary syndrome (PCOS). DESIGN:Retrospective data analysis. SETTING:Volunteers women in an academic research environment. PATIENT(S):Eighty amenorrheic or oligomenorrheic ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(01)01919-7
更新日期:2001-08-01 00:00:00
abstract::Insulin-like growth factor I (IGF-I) has been proposed to be an autocrine/paracrine factor involved in granulosa cell proliferation and differentiation. The present study focuses on a possible mitogenic effect of IGF-I in human granulosa cells. Insulin-like growth factor I (1 to 10 ng/mL) significantly stimulated 3H-t...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00