当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > Tumor necrosis factor α up-regulates endometrial milk fat globule-epidermal growth factor 8 protein production via nuclear factor κB activation, resulting in cell migration of epithelial cells.

Tumor necrosis factor α up-regulates endometrial milk fat globule-epidermal growth factor 8 protein production via nuclear factor κB activation, resulting in cell migration of epithelial cells.

Abstract：

OBJECTIVE:To explore the role of tumor necrosis factor (TNF) α, an early embryonic product, on endometrial epithelial cell migration and endometrial milk fat globule-epidermal growth factor 8 protein (MFG-E8) production. DESIGN:In vitro study. SETTING:Academic center. INTERVENTION(S):Ishikawa cells, used as surrogates for human epithelial cells, were treated with and without TNF-α. MAIN OUTCOME MEASURE(S):Effect of TNF-α on intracellular MFG-E8 protein was evaluated with the use of ELISA, Western blot, and subcellular fractionation. Specific inhibitors were used to study TNF-α mechanism of action. Effect of TNF-α on cell migration was studied with the use of a wound healing assay and reorganization of E-cadherin. RESULT(S):TNF-α induced: 1) significant up-regulation of MFG-E8 intracellular protein, which was attenuated by pretreatment with a specific inhibitor of nuclear factor κB; 2) increased transcription of MFG-E8 and other proinflammatory factors, such as interleukins 6 and 8, which were suppressed by cotreatment with hCG; and 3) significant cell migration with E-cadherin remodeling, changes associated with subcellular MFG-E8 relocalization. CONCLUSION(S):TNF-α up-regulates endometrial epithelial cell migration and MFG-E8 production, which are critical steps required for the endometrial changes during menstrual cycle as well as during embryonic attachment and invasion.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Yu L,Anderson S,Oehninger S,Bocca S

doi

10.1016/j.fertnstert.2013.10.032

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

552-9

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(13)03195-6

journal_volume

101

pub_type

杂志文章

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