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Evaluation of endometrial activin A secretion for prediction of pregnancy after intrauterine insemination.

Abstract：

OBJECTIVE:To measure activin A concentrations in uterine washing fluid collected from women with couple infertility undergoing intrauterine insemination (IUI). DESIGN:Retrospective case-control study. SETTING:Tertiary university center for women's care. PATIENT(S):Fifty women, of whom 25 became pregnant after up to three IUI attempts and 25 did not. INTERVENTION(S):Endocrine and clinical evaluation, semen analyses and hypo-osmotic swelling test, ovarian stimulation, endometrial thickness measurement by ultrasound, uterine washing fluid collection by sonohysterography, and IUI. MAIN OUTCOME MEASURE(S):Activin A measurement by enzyme-linked immunosorbent assay, receiver operating characteristics curve analysis, and pregnancy rates after IUI; sensitivity, specificity, positive and negative likelihood ratios of activin A, and endometrial thickness for pregnancy prediction. RESULT(S):Activin A was measurable in all samples evaluated, and the levels (mean +/- SEM) were statistically significantly higher in the pregnant (0.08 +/- 0.01 ng/mL) than in the nonpregnant (0.022 +/- 0.001 ng/mL) group. Activin A at the cut off of 0.04 ng/mL achieved a sensitivity of 76.0 % (95% CI, 54.9%-90.6%) and a specificity of 100% (95% CI, 86.2%-100%) as a single marker for prediction of pregnancy. CONCLUSION(S):Activin A is secreted into uterine lumen; the levels in endometrial washing fluids were higher in women who subsequently became pregnant after IUI, so its measurement may be useful in predicting successful implantation.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Florio P,Bruni L,Galleri L,Reis FM,Borges LE,Bocchi C,Litta P,De Leo V,Petraglia F

doi

10.1016/j.fertnstert.2008.12.125

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

2316-20

issue

7

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(08)04829-2

journal_volume

93

pub_type

杂志文章

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