Sperm chromatin damage impairs human fertility. The Danish First Pregnancy Planner Study Team.

Abstract:

OBJECTIVE:To examine the relationship between sperm chromatin defects, evaluated by the flow cytometric (FCM) sperm chromatin structure assay (SCSA), and the probability of a pregnancy in a menstrual cycle (fecundability). DESIGN:Follow-up study. SETTING:The Section of Toxicology and Biomedical Sciences, ENEA Casaccia, Rome, Italy, and the Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark. PATIENT(S):Two hundred fifteen Danish first pregnancy planners with no previous knowledge of their fertility capability. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Semen samples were collected at enrollment to measure semen volume, sperm concentration, motility, and morphology (by microscopy), as well as chromatin susceptibility to in situ, acid-induced partial denaturation by the FCM SCSA. Time to pregnancy was evaluated during a 2-year follow-up period. Demographic, medical, reproductive, occupational, and lifestyle data were collected by questionnaire. Fecundability was correlated with SCSA-derived parameters. RESULT(S):Fecundability declines as a function of the percentage of sperm with abnormal chromatin and becomes small when aberrant cells are >40%. CONCLUSION(S):Optimal sperm chromatin packaging seems necessary for full expression of the male fertility potential. The SCSA emerged as a predictor of the probability to conceive in this population-based study.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Spanò M,Bonde JP,Hjøllund HI,Kolstad HA,Cordelli E,Leter G

doi

10.1016/s0015-0282(99)00462-8

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

43-50

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015028299004628

journal_volume

73

pub_type

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