Abstract:
OBJECTIVE:Evaluate the effectiveness of a new ovarian stimulation (OS) protocol before IVF. DESIGN:Prospective clinical randomized trial. SETTING:Private centers. PATIENT(S):Three hundred and twenty-three intended-to-treat women candidates for IVF. INTERVENTION(S):Patients were divided into three groups and administered the following treatments: group A, recombinant hFSH from day 3 until follicles reached 13-14 mm, when recombinant hFSH was lowered to 75 IU daily and daily injections of 200 IU of hCG and a GnRH antagonist were administered until final maturation; group B, recombinant hFSH and a GnRH antagonist; group C, recombinant hFSH and a GnRH agonist. MAIN OUTCOME MEASURE(S):Primary outcome was the number of mature oocytes. Secondary outcomes included average initial and total recombinant hFSH dosage, serum E2 level on day of ovulation, number of oocytes retrieved, fertilization, number of top-quality embryos, endometrial thickness, implantation rate, pregnancy rate (PR), and incidence of ovarian hyperstimulation syndrome (OHSS). RESULT(S):The numbers of oocytes retrieved, mature oocytes, fertilization, top-quality embryos, and embryos transferred were comparable in all groups. Implantation rate, PR, and incidence of OHSS were also comparable. The total dose of recombinant hFSH was significantly lower in group A (1,674.7 +/- 59.4 IU, vs. 2,197.9 +/- 77.8 IU in group B and 2,156.7 +/- 80.9 IU in group C). CONCLUSION(S):This new OS protocol permits follicles and oocytes to fully develop, helps generate top-quality embryos, avoids premature ovulation, establishes clinical pregnancies, reduces administration of recombinant hFSH, minimizes costs, and does not increase the chances of OHSS.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Serafini P,Yadid I,Motta EL,Alegretti JR,Fioravanti J,Coslovsky Mdoi
10.1016/j.fertnstert.2006.02.110subject
Has Abstractpub_date
2006-10-01 00:00:00pages
830-8issue
4eissn
0015-0282issn
1556-5653pii
S0015-0282(06)01160-5journal_volume
86pub_type
杂志文章,随机对照试验abstract::A 26-year-old patient underwent pelvic lymphadenectomy and trachelectomy because of cervical cancer stage IB. Later she developed symptoms from obturator nerve entrapment. Examinations could not reveal metastatic cancer disease, but endometriosis surrounding the obturator nerve was discovered. Laparoscopic removal of ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.03.024
更新日期:2009-02-01 00:00:00
abstract::The purpose of this study was to determine whether routine prolactin measurement was of use when investigating men with infertility. Prolactin levels were slightly higher in men with primary infertility, compared with men with secondary infertility and a fertile control group. Although this slight increase was statist...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)45862-0
更新日期:1981-11-01 00:00:00
abstract:OBJECTIVE:To investigate the utility of random anti-Müllerian hormone (AMH) in assessing ovarian response among women with diminished ovarian reserve (DOR) diagnosed by elevated early follicular-phase FSH levels. DESIGN:Retrospective study. SETTING:Academic and academically affiliated assisted reproductive technology...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.03.071
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:To study the effect of human plasma from different sources, namely, umbilical cord blood and adult blood platelet-rich plasma (PRP), on the regeneration of endometrial damage. DESIGN:Composition analysis, in vitro approaches, and a preclinical murine model using plasma to promote endometrial regeneration. S...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2020.07.053
更新日期:2020-08-24 00:00:00
abstract::The effect of different concentrations of prolactin (0 to 60 ng) on the release of tetracycline from human spermatozoa labeled with 7-3H-tetracycline hydrochloride was studied. Prolactin significantly enhanced the release of bound tetracycline, indicating that prolactin may influence the processes associated with sper...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)43219-x
更新日期:1978-04-01 00:00:00
abstract::The effects of various concentrations of rosiglitazone on in vitro rat embryo growth and morphology during the critical period of organogenesis was evaluated. We found that rosiglitazone has no significant effects on growth and morphology of in vitro early embryo development, even at very high concentrations. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.12.069
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that oligo-ovulatory ovulation is associated with hyperandrogenemia in the absence of other clinical signs of androgen excess. DESIGN:Retrospective cohort controlled. SETTING:Tertiary care university-based outpatient clinic. PATIENT(S):Thirty-two consecutive nonhirsute oligo-ovulator...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)80089-1
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:To determine whether polymorphisms in the estrogen receptor (ER) alpha and beta genes are associated with endometriosis in a Japanese population. DESIGN:Association study. SETTING:University hospital. PATIENT(S):Japanese women diagnosed with endometriosis by laparotomy or laparoscopy. INTERVENTION(S):Dete...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2004.02.094
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:To test for an association between DNA fragmentation and head shape at high magnification in fresh motile spermatozoa. DESIGN:Observational study. SETTING:Academic tertiary care center. PATIENT(S):A total of 60 men in our assisted reproductive program. INTERVENTION(S):Quantifying sperm head shape using el...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2013.01.100
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:To determine whether complete failure of fertilization of oocytes in couples with unexplained infertility persists during subsequent in vitro fertilization (IVF) cycles. DESIGN:A retrospective study of 120 cycles of IVF in 44 couples with unexplained infertility and complete failure of fertilization during t...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55677-5
更新日期:1993-02-01 00:00:00
abstract:OBJECTIVE:To investigate the role of heart and neural crest derivatives-expressed transcript 2 (HAND2) during decidualization of human endometrial stromal cells (ESCs). DESIGN:In vitro experiment. SETTING:Research laboratory. PATIENT(S):Twenty-six patients undergoing hysterectomy for benign reasons. INTERVENTION(S)...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2014.03.013
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:To compare the FSH threshold level for follicle growth up to the preovulatory stage between superovulated and natural cycles. DESIGN:Normally cycling women were investigated during an untreated spontaneous cycle (control) and three cycles treated with FSH. SETTING:Infertility clinic in a university hospital...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)57610-9
更新日期:1995-06-01 00:00:00
abstract:OBJECTIVE:To investigate whether proteins secreted in urine differ between women with and without endometriosis. DESIGN:Laboratory study using human urine. SETTING:University-based laboratory. PATIENT(S):Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage. INTERVENTION(S):Urine c...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.05.016
更新日期:2011-01-01 00:00:00
abstract::This retrospective cohort study compared blastocyst transfers in 136 fresh oocyte donor cycles and 69 autologous cycles using blastocysts derived from culture of thawed bipronuclear oocytes, all with oocytes derived from patients or donors less than 35 years old. The autologous cycles and oocyte donor cycles had simil...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.07.966
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of resveratrol on growth and function of granulosa cells. Previously, we demonstrated that resveratrol exerts profound proapoptotic effects on theca-interstitial cells. DESIGN:In vitro study. SETTING:Research laboratory. ANIMAL(S):Immature Sprague-Dawley female rats. INTERVENTION(S...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.08.004
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To describe a novel mutation in the fumarate hydratase (FH) gene in a family with atypical uterine leiomyomas. DESIGN:Case report and review of the literature. SETTING:Academic community hospital. PATIENT(S):Three sisters who presented as nulligravidas aged 27-30 years with large atypical uterine leiomyoma...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.09.034
更新日期:2016-01-01 00:00:00
abstract::To explore the relationship between variation in AGT M235T gene and the development of the polycystic ovary syndrome (PCOS) and its sequelae, in the present study we evaluated AGT polymorphism M235T in women with PCOS and in a control group. Moreover, to detect any relationship between AGT M235T variation and intermed...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.05.043
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:To examine proteins aberrantly expressed in the ectopic endometrium compared with eutopic endometrium from the same patient. DESIGN:Experimental study. SETTING:Research institute and an obstetrics and gynecology clinic (National Institute for Research in Reproductive Health and Sanjeevani Diagnostic Center ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.01.048
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:To determine the effect of moderate alcohol intake on probability of conception. DESIGN:Prospective cohort study. SETTING:Normal healthy women enrolled in an artificial donor insemination program. PATIENTS:Women starting artificial donor insemination for the very first time were selected. INTERVENTIONS:Al...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)57056-3
更新日期:1994-11-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between endogenous serum levels of human growth hormone (hGH) and ovarian response to human menopausal gonadotropins (hMG). DESIGN:Retrospective analysis of patient response to hMG. SETTING:Center for assisted reproductive technology. PATIENTS:Eighty women who had undergone ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55133-4
更新日期:1992-07-01 00:00:00
abstract::Several regimens have been developed to administer gonadotropin-releasing hormone agonists in association with human menopausal gonadotropins (hMG) during follicular growth stimulation for in vitro fertilization. The aim of this study was to characterize hormonal changes induced by short-term administration of agonist...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0015-0282(16)60437-5
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:To investigate the use of medroxyprogesterone acetate (MPA) to prevent LH surge during controlled ovarian hyperstimulation (COH) and to compare cycle characteristics and pregnancy outcomes in subsequently frozen-thawed ET (FET) cycles. DESIGN:A prospective controlled study. SETTING:Tertiary-care academic me...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.03.022
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To assess the ability of a GnRH antagonist (Cetrorelix, Asta Medica AG, Frankfurt, Germany) to prevent premature LH surges in an IVF-ET program using a simple protocol with one or two administrations. DESIGN:Controlled ovarian hyperstimulation was carried out in 17 women with three ampules a day of hMG, star...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(16)56933-7
更新日期:1994-09-01 00:00:00
abstract::The use of modified natural-cycle in vitro fertilization (IVF) is a valuable alternative to controlled ovarian hyperstimulation in young poor responders and should be considered in patients who require IVF and demonstrate endocrinologic evidence of ovarian aging and in those who have had one or two canceled controlled...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.09.052
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To elucidate the role of interleukin-1β (IL-1β) on cyclooxygenase-2 (COX-2) expression and invasion of endometrioma-derived ectopic endometrial mesenchymal stem cells (EN-MSCs) and to develop an organoid method to study the invasive ability of endometrial cells. DESIGN:Gene expression and cell functions. SE...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.06.041
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:Studies have shown that age at natural menopause is heritable. Mutations in the FSH-receptor have been identified in women with premature ovarian failure (POF) and the FSH-receptor gene may, therefore, be considered a candidate gene for (early) menopausal age. This study investigates whether there is linkage ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2003.08.017
更新日期:2004-03-01 00:00:00
abstract::Genetic factors, especially numerical chromosome anomalies, play an important role in embryonic loss. Because somatic cell analysis cannot assess the risk of errors arising de novo during germ cell maturation, we investigated whether the male gametes from couples with habitual abortion carry a higher rate of anomalies...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)54505-1
更新日期:1991-08-01 00:00:00
abstract::Pelvic adhesion formation represents a major problem following fallopian tube surgery for infertility. Intraperitoneal dextran may prevent pelvic adhesions. Extensive personal clinical experience (W. H. U.) with intraperitoneal dextran organ-flotation on completion of tubal and ovarian surgery has appeared to limit ad...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)43765-9
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVE:To describe ovulation induction and pregnancy outcome in a unique model of genetically determined combined pituitary hormone deficiency (CPHD), with respect to the necessity for GH substitution therapy. DESIGN:Case report. SETTING:Academic units. PATIENT(S):Two patients with childhood onset of CPHD (GH, PR...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2004.03.026
更新日期:2004-08-01 00:00:00
abstract::Characterization of the implanting human fetus as an allograft prompted a field of research in reproductive immunology that continues to fascinate and perplex scientists. Paternal- or partner-derived alloantigens are present in the maternal host at multiple times during the reproductive process. They begin with exposu...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2016.07.1073
更新日期:2016-09-01 00:00:00