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The effectiveness of intracytoplasmic sperm injection combined with piezoelectric stimulation in infertile couples with total fertilization failure.

Abstract：

OBJECTIVE:To assess the effectiveness of intracytoplasmic sperm injection (ICSI) combined with piezoelectric stimulation in infertile couples with a history of total fertilization failure (TFF). DESIGN:Prospective controlled trial. SETTING:Clinical IVF laboratory. PATIENT(S):Seventy-one couples undergoing ICSI on sibling oocytes having at least one previous ICSI attempt with TFF. INTERVENTION(S):ICSI or ICSI with piezoelectric activation. MAIN OUTCOME MEASURE(S):Fertilization rate. RESULT(S):The patients were allocated to two groups: group I included 21 patients with only one previous TFF and group II included 50 patients with more than one previous TFF. Collectively, a total of 823 metaphase II (MII) oocytes were retrieved in 78 oocyte retrievals. In Group I, combined ICSI with piezoelectric stimulation was applied to 123/211 (58.2%) of MII oocytes (group IA), whereas standard ICSI procedure was applied to 88/211 (41.8%) of MII oocytes (group IB). The fertilization rate was 62% and 12% in group IA and group IB respectively. In group II, piezoelectric activation was applied in all 612 MII oocytes, of which 296 (48.3%) were fertilized. The rates for implantation and pregnancy/embryo transfer were obtained as 30.6% and 44.1%, respectively. CONCLUSION(S):Piezoelectric activation seems to improve IVF outcome in patients with previous TFF history.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Baltaci V,Ayvaz OU,Unsal E,Aktaş Y,Baltaci A,Turhan F,Ozcan S,Sönmezer M

doi

10.1016/j.fertnstert.2009.03.107

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

900-4

issue

3

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(09)00777-8

journal_volume

94

pub_type

杂志文章,随机对照试验

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