Ovarian steroid hormones differentially regulate thrombospondin-1 expression in cultured endometrial stromal cells: implications for endometriosis.

Abstract:

:Thrombospondin-1 messenger RNA and protein levels in cultured human endometrial stromal cells (ESCs) treated with 17-beta estradiol (10 nM) were reduced by 47.6% (+/-6.5% SD; P < 0.05) and 49.0% (+/-8.6%; P < 0.05) compared with untreated cells, whereas thrombospondin-1mRNA and protein levels in ESCs treated with progesterone (10 microM) were 2.1-fold (+/-0.4 SD; P < 0.05) and 2.3-fold (+/-0.6; P < 0.05) higher than those in untreated cells. These findings not only provide evidence for the estrogen dependence of endometriosis, but also partly explain the mechanisms by which progestins exert their therapeutic activities in endometriosis.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Tan XJ,Lang JH,Zheng WM,Leng JH,Zhu L

doi

10.1016/j.fertnstert.2009.06.060

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

328-31

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(09)02402-9

journal_volume

93

pub_type

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