Spontaneous variation of leukocytospermia in asymptomatic infertile males.

Abstract:

OBJECTIVE:To investigate the spontaneous variation of leukocytospermia (>1 million/mL) in semen samples from infertile men. DESIGN:Prospective cohort study. SETTING:Andrologic clinic at university hospital. PATIENT(S):Ninety-nine men evaluating for infertility causes. INTERVENTION(S):Two semen analyses according the World Health Organization criteria combined with urologic investigation without any treatment. MAIN OUTCOME MEASURE(S):Spontaneous (downward/upward) variation in leukocyte count, sperm concentration, total motility, and morphology between the two semen samples. RESULT(S):In the first semen analysis, 21% of men had leukocytospermia. By the second analysis, leukocyte concentrations were within the normal range in 9 of these 21 men, corresponding to a downward variation of 43%. In contrast, 7 of 78 patients with normal leukocyte levels at the first analysis had leukocytospermia at the second analysis, corresponding to an upward variation of 9%. The upward variation rates for sperm concentration, total motility, and morphology were 4%, 17%, and 4%, respectively. Downward variation rates were considerably higher for total motility and morphology (30% and 28%, respectively). CONCLUSION(S):The rate for spontaneous downward variation of leukocytospermia in the absence of treatment was 43% in this study. This rate should be taken into consideration when treating infertile men with leukocytospermia, because effective medical therapy is still lacking.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Lackner JE,Lakovic E,Waldhör T,Schatzl G,Marberger M

doi

10.1016/j.fertnstert.2007.08.041

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

1757-60

issue

5

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(07)03291-8

journal_volume

90

pub_type

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