Abstract:
OBJECTIVE:Racial disparity in assisted reproductive technology (ART) outcomes has been reported but remains controversial. Reasons for the disparity are unclear, and access to care has been suggested as a causative factor. In this study, we sought to examine minority utilization of ART in the Department of Defense (DoD) compared with minority utilization in the U.S. ART population. Outcomes from ART were compared between Caucasian (Cau) and African American (AA) patients, and etiologies of disparity were examined. DESIGN:Retrospective cohort study. SETTING:University-based ART program. PATIENT(S):A total of 1,457 patients undergoing first-cycle fresh, nondonor ART. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Clinical pregnancy rate, live birth rate, implantation rate, spontaneous abortion rate. RESULT(S):Within the DoD population, AA women had a fourfold increase in utilization of ART services relative to the U.S. ART population. In this equal-access-to-care setting, AA women experienced a clinically significant decrease in live birth rate that did not reach statistical significance (29.6% vs. 35.8%, risk ratio [RR] 0.83, 95% confidence interval [CI] 0.67-1.02) and a statistically significant increase in spontaneous abortions compared with Cau women (25% vs. 15.9%, RR 1.57, 95% CI 1.05-2.36). This might be explained, in part, by a higher prevalence of uterine leiomyomas in AA women (30.8% AA vs. 10.7% Cau, RR 2.85, 95% CI 2.06-3.95). For both AA and Cau women, the presence of fibroids at baseline ultrasound was associated with reductions in clinical pregnancy rates (35% with leiomyomas vs. 43.2% without leiomyomas, RR 0.74, 95% CI 0.51-0.98), live birth rates (26.2% vs. 36.0%, RR 0.63, 95% CI 0.44-0.90), and implantation rates (25.6% vs. 31.1% RR 0.82, 95% CI 0.69-0.98). CONCLUSION(S):Utilization of ART services among AA women increased when access to care was improved. A clinically significant reduction in live birth rate and statistically significant increase in spontaneous abortion rate was observed in AA women compared with Cau women. Leiomyomas were three times more prevalent in AA women and reduced ART success, regardless of race. The persistence of racial differences in an equal-access-to-care environment might be explained, in part, by the increased prevalence of leiomyomas in AA women.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Feinberg EC,Larsen FW,Catherino WH,Zhang J,Armstrong AYdoi
10.1016/j.fertnstert.2005.10.028keywords:
subject
Has Abstractpub_date
2006-04-01 00:00:00pages
888-94issue
4eissn
0015-0282issn
1556-5653pii
S0015-0282(05)04328-1journal_volume
85pub_type
杂志文章abstract:OBJECTIVE:To evaluate clinical outcomes of day 2 versus day 3 ET using a culture media with no glucose or phosphate. DESIGN:Retrospective clinical study. SETTING:Hospital-based fertility clinic. PATIENT(S):One hundred seventy-six IVF-ET patients undergoing controlled ovarian supraovulation. INTERVENTION(S):IVF and ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)00499-8
更新日期:1998-02-01 00:00:00
abstract::Serum and peritoneal fluid from five fertile women without endometriosis and serum (n = 23) and peritoneal fluid (n = 12) from infertile women with endometriosis were tested for the presence of antibodies against endometrial tissue antigens by a Western blot analysis. Antigens with molecular weights (MW) of 19, 31, 38...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60362-x
更新日期:1988-12-01 00:00:00
abstract::All in vitro fertilization (IVF) programs and clinics should have a plan to protect fresh and cryopreserved human tissue (embryos, oocytes, sperm) and to provide for continuation of patient care in the event of an emergency or natural disaster. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.08.063
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:To compare the agonist flare-up and antagonist protocols in the management of poor responders to the standard long down-regulation protocol. DESIGN:Retrospective comparative study. SETTING:Assisted conception center. PATIENT(S):One hundred thirty-four patients undergoing IVF/ intracytoplasmic sperm injecti...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2004.07.963
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:To explore the role of tumor necrosis factor (TNF) α, an early embryonic product, on endometrial epithelial cell migration and endometrial milk fat globule-epidermal growth factor 8 protein (MFG-E8) production. DESIGN:In vitro study. SETTING:Academic center. INTERVENTION(S):Ishikawa cells, used as surrogat...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2013.10.032
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:To report a case of bilateral ovarian fibromas and ovarian leiomyomas in a young patient with Gorlin syndrome and to highlight issues of fertility preservation, ovarian conservation, and preimplantation genetic diagnosis in this population. DESIGN:Case report. SETTING:University hospital. PATIENT(S):A 15-y...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.04.028
更新日期:2011-07-01 00:00:00
abstract::We found that four polymorphisms in the protein L-isoaspartyl-O-methyltransferase (PCMT1) gene, encoding a protein repair enzyme, are associated with premature ovarian failure (POF). All four polymorphisms were in strong linkage disequilibrium. The frequencies of two haplotypes were statistically significantly differe...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.03.078
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To assess the efficiency of two vitrification protocols to cryopreserve human preantral follicles with the use of a xenografting model. DESIGN:Pilot study. SETTING:Gynecology research unit in a university hospital. PATIENT(S):Ovarian biopsies were obtained from seven women aged 30-41 years. INTERVENTION(S...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.07.1109
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To describe a case of bilateral internal jugular vein thrombosis complicating ovarian hyperstimulation syndrome (OHSS). DESIGN:Case report. SETTING:Internal medicine ward in a teaching hospital. PATIENT:A 28-year-old nulliparous woman undergoing IVF. INTERVENTION(S):Ultrasonographic Doppler of the neck ve...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)00459-7
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To present two exemplary cases of adenomatoid tumors. DESIGN:Case report. SETTING:Two laparoscopic centers in Germany. PATIENT(S):Two women of reproductive age with uterine adenomatoid tumors. INTERVENTION(S):Laparoscopic tumor excision. MAIN OUTCOME MEASURE(S):Differential diagnostics of uterine masses....
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2010.10.017
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:To test, using the immunobead binding technique, for the presence of antisperm antibodies on epididymal sperm, in epididymal fluid, and in serum of men with congenital absence of the vas deferens. To evaluate the in vitro fertilization (IVF) capacity of human epididymal sperm in the presence of antisperm ant...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55451-x
更新日期:1992-11-01 00:00:00
abstract::Because the size of leiomyomata uteri often decreases significantly after menopause, the authors elected to employ a long-acting gonadotropin hormone-releasing hormone analog (GnRH-alpha) (imbzl-D-His6-Pro9-Net-GnRH) to create a state of pseudomenopause in six patients with leiomyomata uteri diagnosed on the basis of ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)49332-5
更新日期:1986-05-01 00:00:00
abstract::This monograph, written by the pioneers of IVF and reproductive medicine, celebrates the history, achievements, and medical advancements made over the last 40 years in this rapidly growing field. ...
journal_title:Fertility and sterility
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.fertnstert.2018.06.005
更新日期:2018-07-15 00:00:00
abstract:OBJECTIVE:To determine whether high levels of interleukin (IL)-10 can attenuate the production of tumor necrosis factor (TNF)-alpha-induced proinflammatory cytokines in endometriotic stromal cells. DESIGN:Prospective study. SETTING:Department of Ob/Gyn, Tottori University, Japan. PATIENT(S):Thirty-five patients with...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.04.052
更新日期:2009-05-01 00:00:00
abstract::Twenty-seven sexually mature Japanese monkeys (Macaca fuscata fuscata) weighing 6 to 8 kg were used to evaluate and characterize the local and systemic effects of a T-shaped progesterone-releasing system (UTS) following transabdominal insertion into the uterus. None of five experimental animals conceived, while four o...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)41842-x
更新日期:1976-05-01 00:00:00
abstract:OBJECTIVES:To examine and discuss the pathology, diagnosis, incidence, and patient profile of salpingitis isthmica nodosa and to question its natural history, propose management strategies, and identify areas of promising research. DESIGN:Over 50 studies were reviewed, evaluated, and compared to offer the clinician a ...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/s0015-0282(16)56207-4
更新日期:1993-10-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy of tibolone add-back therapy with Goserelin treatment of uterine fibroids. DESIGN:Randomized placebo-controlled study. SETTING:Gynecology department of an inner-city teaching hospital. PATIENT(S):Seventy-five women of reproductive age with uterine fibroids. INTERVENTION(S):All women...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2007.02.064
更新日期:2008-02-01 00:00:00
abstract::Salpingitis isthmica nodosa has been studied in relation to female infertility and tubal ectopic pregnancy. The incidence of this lesion in a control Caucasian population was 0.6%, as compared with incidences of 2.86% in an ectopic group and 50% in a small infertility group undergoing tuboplasty. It is suggested that ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1978-02-01 00:00:00
abstract:OBJECTIVE:To determine whether endometrial hCG infusion at the time of human blastocyst transfer impacts implantation rates. DESIGN:Randomized double-blinded placebo-controlled trial. SETTING:Academic. PATIENT(S):Infertile couples with the female partner less than 43 years old (n = 300) undergoing fresh or frozen ET...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2014.08.006
更新日期:2014-12-01 00:00:00
abstract::Nitrofurantoin sodium and nitorfurazone, in certain critical concentrations, have the ability to immobilize spermatozoa. In this study, this effect was consisitent with both 5:1, and 10:1 dilutions. Histologic examination of the effects of these drugs as intraoperative vas irrigants revealed no apparent tissue toxicit...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)41168-4
更新日期:1975-06-01 00:00:00
abstract:OBJECTIVE:To improve the maturation rate of murine and human germinal vesicle (GV) oocytes using human tubal epithelial cells (hTECs). DESIGN:Murine and human GV oocytes were randomized to human tubal fluid (HTF) media alone or cocultured with mouse embryonic fibroblasts (MEFs) or primary hTECs or immortalized hTECS (...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.08.034
更新日期:2011-03-15 00:00:00
abstract::A retrospective review of 237 initial, fresh nondonor IVF cycles in which all embryos generated during the cycle were transferred on either day 2 (n = 109) or day 3 (n = 128) were evaluated with regards to reproductive outcomes. Patients who underwent a day 2 ET had similar conception (18% vs. 16%; relative risk [RR],...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.10.010
更新日期:2011-03-01 00:00:00
abstract::Cell proliferation of endometrial stromal cells treated with peritoneal fluid of women (aged 25 to 43 years) with endometriosis (n = 12) statistically significantly increased compared with the control treatment (peritoneal fluid of women without endometriosis, n = 8). Also, COX-2 gene expression and prostaglandin E(2)...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.11.039
更新日期:2011-04-01 00:00:00
abstract::Fresh and aged (24 hours after ovulation) human oocytes and recently ovulated mouse oocytes may be activated by exposure to acidified Tyrode's solution. No activation of either type of human oocyte was observed after exposure to hyaluronidase or pronase, but significant numbers of fresh mouse oocytes were activated af...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53279-8
更新日期:1990-02-01 00:00:00
abstract::A 26-year-old patient underwent pelvic lymphadenectomy and trachelectomy because of cervical cancer stage IB. Later she developed symptoms from obturator nerve entrapment. Examinations could not reveal metastatic cancer disease, but endometriosis surrounding the obturator nerve was discovered. Laparoscopic removal of ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.03.024
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:To assess the occult pregnancy rate after "negative" first post-embryo transfer (ET) serum β-hCG results. DESIGN:Two-part retrospective cohort study and nested case series. SETTING:University-based fertility center. PATIENT(S):A total of 1,571 negative first post-ET serum β-hCG results were included in the...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.11.049
更新日期:2016-04-01 00:00:00
abstract::Postoperative adhesions are a natural consequence of surgical tissue trauma and healing and may result in infertility, pain, and bowel obstruction. Adherence to microsurgical principles, minimally invasive surgery, and use of some peritoneal instillates may help to decrease postoperative adhesions. Some surgical barri...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2007.04.066
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the immunoactivity of human follicular fluids (FFs) of ovaries stimulated with exogenous gonadotropins. PARTICIPANTS:Follicular fluids and peripheral blood mononuclear cells (PBMCs) were obtained at the time of ovum pick-up from 15 women (25 to 34 years of age) undergoing gonadotropin stimulation...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)56886-1
更新日期:1994-08-01 00:00:00
abstract:OBJECTIVE:To determine association of cytokine gene polymorphism with risk for recurrent miscarriages (RM). DESIGN:Retrospective case-control study on northern Indian RM cases versus control subjects. SETTING:Medical facility. PATIENT(S):A total of 200 women with at least three unexplained spontaneous abortions befo...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.09.025
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:We previously reported an antipeptide antibody to human glycodelin that recognizes glycodelin in amniotic fluid and epithelial glands of the endometrium. The objective of this study was to determine the presence of glycodelin in human umbilical cord. DESIGN:Controlled clinical study. SETTING:Healthy women u...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(99)00599-3
更新日期:2000-04-01 00:00:00