Endometrial antigens involved in the autoimmunity of endometriosis.


:Serum and peritoneal fluid from five fertile women without endometriosis and serum (n = 23) and peritoneal fluid (n = 12) from infertile women with endometriosis were tested for the presence of antibodies against endometrial tissue antigens by a Western blot analysis. Antigens with molecular weights (MW) of 19, 31, 38, and 42 kd reacted with antibodies in the serum and peritoneal fluid from both fertile and infertile women. Antibodies in 20 of 23 (87%) sera and all 12 (100%) peritoneal fluid samples from endometriosis patients reacted against endometrial antigens with molecular weights (MW) of 26 kd and/or 34 kd. Serum from 10 patients (43%) and peritoneal fluid from 6 patients (50%) also had antibodies to an endometrial antigen with MW of 21.5 kd. Reactivity to other endometrial antigens with MW 16, 24, 48, and 75 kd was also noted in patients with endometriosis. Antibodies in the serum and peritoneal fluid from fertile women failed to react against these antigens. It is concluded that the humoral and local endometrial autoimmunity detected in patients with endometriosis is primarily directed against antigens with MW of 26 and 34 kd.


Fertil Steril


Fertility and sterility


Mathur S,Chihal HJ,Homm RJ,Garza DE,Rust PF,Williamson HO




Has Abstract


1988-12-01 00:00:00














  • Pharmacodynamics of the antiprogesterone RU486 in women after oral administration.

    abstract::The pharmacokinetic characteristics of RU486 and its acute effects on anterior pituitary hormone secretion after oral administration were examined in six normal women. Serum RU486 concentrations were determined by a radioimmunoassay. The absorption of RU486 was rapid with peak serum levels reached approximately 90 min...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Liu JH,Garzo VG,Yen SS

    更新日期:1988-08-01 00:00:00

  • Embryo implantation during menstruation in the absence of adequate estradiol and progesterone support, with subsequent normal response to ovulation induction and superfetation.

    abstract:OBJECTIVE:To report an unusual case of embryo implantation and superfetation. DESIGN:Retrospective case analysis. SETTING:Oak Brook Fertility Center. PATIENT(S):A 41-year-old woman underwent two consecutive ovarian stimulation cycles interrupted by a normal menstrual period. Ovulation and implantation occurred durin...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Dmowski WP,DeOrio L,Rana N

    更新日期:1997-09-01 00:00:00

  • Changes of bioactive luteinizing hormone after laparoscopic ovarian cautery in patients with polycystic ovarian syndrome.

    abstract::The serum levels of bioactive luteinizing hormone (LH), immunoreactive LH, follicle-stimulating hormone, androstenedione (A), and testosterone (T) were determined in nine anovulatory women with polycystic ovarian syndrome (PCOS) before and after laparoscopic ovarian cautery. Eight ovulated spontaneously and three conc...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Sakata M,Tasaka K,Kurachi H,Terakawa N,Miyake A,Tanizawa O

    更新日期:1990-04-01 00:00:00

  • Polyglycolic acid/chitosan glue and apoptosis of endometriotic cells.

    abstract:OBJECTIVE:To induce apoptosis of endometriotic cells of patients with endometriosis. DESIGN:To demonstrate that polyglycolic acid/chitosan glue directly inhibits cell proliferation by inducing apoptosis. SETTING:University hospital infertility center. PATIENT(S):Twelve women who visited the center for infertility th...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Wang YC,Fu RH,Hsieh HJ,Chao HT,Kao SH

    更新日期:2005-07-01 00:00:00

  • Introduction: Uterus transplantation.

    abstract::Uterus transplantation is the first available treatment for absolute uterine factor infertility. Live births have been reported after transplantation of uteri both from live and deceased donors. Although this novel infertility treatment is still at its experimental stage, with human attempts performed within clinical ...

    journal_title:Fertility and sterility



    authors: Brännström M

    更新日期:2019-07-01 00:00:00

  • Nerve fibers and menstrual cycle in peritoneal endometriosis.

    abstract::There was no difference in the density of nerve fibers across the menstrual cycle in peritoneal endometriotic lesions. These findings may explain why patients with peritoneal endometriosis often have painful symptoms throughout the menstrual cycle. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Wang G,Tokushige N,Fraser IS

    更新日期:2011-06-30 00:00:00

  • The initial experience with the use of a portable infusion pump in the delivery of human menopausal gonadotropins.

    abstract::The initial experience with the use of a portable infusion pump for the delivery of human menopausal gonadotropins (hMG) in the therapy of ovulation dysfunction of women who failed to conceive following (1) either clomiphene citrate (five patients with polycystic ovary syndrome) or danazol (three patients with mild en...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kemmann E,Brandeis VT,Shelden RM,Nosher JL

    更新日期:1983-10-01 00:00:00

  • Abdominal pregnancy complicated by genital and renal tuberculosts and hemolytic anemia.

    abstract::After a 10-year period of primary infertility, a patient presented with abdominal pregnancy. Known to have had previously treated genital tuberculosis, on admission she was found to have renal tuberculosis and autoimmune hemolytic anemia. After fetal death, laparotomy was performed and the fetus was removed. The patie...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Semchyshyn S,Cecutti A

    更新日期:1975-11-01 00:00:00

  • Intrafollicular insemination for male factor infertility.

    abstract::Intrafollicular insemination is a promising new development that may have a major impact on ART, notably in the treatment of male factor infertility. Reported is the first successful intrafollicular insemination in the United States and the first successful intrafollicular insemination for male factor infertility. Alt...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Zbella EA,Tarantino S,Wade R

    更新日期:1992-08-01 00:00:00

  • Danazol binding to steroid receptors in human uterine endometrium.

    abstract::To understand the mechanism of action of danazol, the binding of danazol to multiple classes of intracellular steroid binding proteins was studied in the human uterine endometrium. Danazol bound to endometrial receptors for estrogen, progesterone, and androgen and seemed to bind to endometrial intracellular corticoste...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Tamaya T,Wada K,Fujimoto J,Yamada T,Okada H

    更新日期:1984-05-01 00:00:00

  • Serum pituitary and steroid hormone levels in the adult male: one value is as good as the mean of three.

    abstract::The result of the hormone concentration of one blood sample was used to determine the accuracy of predicting not only the hormone concentrations of a second and third sample drawn 15 minutes apart, but also the mean value of the three samples. Three blood specimens from 73 men involved in two previously reported studi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Bain J,Langevin R,D'Costa M,Sanders RM,Hucker S

    更新日期:1988-01-01 00:00:00

  • 5Alpha-reductase type 2 genes in Japanese males do not appear to be associated with cryptorchidism.

    abstract:OBJECTIVE:To evaluate the occurrence of mutations of 5alpha-reductase type 2 gene in patients with cryptorchidism or idiopathic azoospermia. DESIGN:Controlled clinical study. SETTING:Yamagata University Hospital, Yamagata and Tokyo Electric Power Company Hospital, Tokyo, Japan. PATIENT(S):Patients with isolated cryp...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Suzuki Y,Sasagawa I,Itoh K,Ashida J,Ogata T

    更新日期:2002-08-01 00:00:00

  • Congenital anomalies and assisted reproductive technology: more of the same.

    abstract::Klemetti's birth registry study is put in context of other major studies. Summary advice is offered to practitioners as to what they should tell parents who conceive with assisted reproductive technology. ...

    journal_title:Fertility and sterility

    pub_type: 评论,信件


    authors: Sutcliffe AG

    更新日期:2005-11-01 00:00:00

  • Adverse outcome in women with thrombophilia and bilateral uterine artery notches.

    abstract::Discrepancies about a possible relationship between prothrombotic mutations and a decreased uteroplacental blood flow are present in literature. We prospectively evaluated a cohort of pregnant women (n = 41) with bilateral uterine artery notches and found that women with inherited thrombophilia showed a sixfold higher...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Grandone E,Colaizzo D,Martinelli P,Paladini D,di Minno G,Margaglione M

    更新日期:2006-09-01 00:00:00

  • Should embryos developing to blastocysts on day 7 be cryopreserved and transferred: an analysis of pregnancy and implantation rates.

    abstract:OBJECTIVE:To compare pregnancy rates (PRs) using blastocysts cryopreserved on day 7 with those cryopreserved on days 5 and 6. DESIGN:Retrospective observational cohort study. SETTING:Infertility center performing IVF. PATIENT(S):Eight hundred women with infertility undergoing frozen ET. INTERVENTION(S):Blastocysts ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kovalevsky G,Carney SM,Morrison LS,Boylan CF,Neithardt AB,Feinberg RF

    更新日期:2013-10-01 00:00:00

  • Miscarriage in India: a population-based study.

    abstract::This study estimated birth order-specific miscarriage rates and characterized the influence of maternal age using the complete birth history of 90,303 ever-married women from the 1998-2000 Indian National Family Health Survey. Rates of miscarriage in India were low in association with early childbearing, whereas birth...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Pallikadavath S,Stones RW

    更新日期:2005-08-01 00:00:00

  • Effects of soy on the mammary glands of premenopausal female monkeys.

    abstract:OBJECTIVE:To evaluate the interactive effects of dietary soy and menstrual cycle phase on breast proliferation, apoptosis, and sex steroid receptor expression in premenopausal female cynomolgus monkeys. DESIGN:Animals were randomized to receive diets with either casein lactalbumin or soy as the protein source for 12 m...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Wood CE,Kaplan JR,Stute P,Cline JM

    更新日期:2006-04-01 00:00:00

  • Decreased human leukocyte antigen-DR expression in the lipid raft by peritoneal macrophages from women with endometriosis.

    abstract:OBJECTIVE:To investigate the macrophage response in endometriosis by determining the expression and localization of human leukocyte antigen (HLA)-ABC and HLA-DR by the peritoneal fluid (PF) macrophages and PF concentrations of interferon (IFN)-gamma that regulate HLA expression. DESIGN:Case-control study. SETTING:Uni...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Yamamoto Y,Maeda N,Izumiya C,Kusume T,Oguri H,Kawashima M,Hayashi K,Nomura A,Yamashita C,Fukaya T

    更新日期:2008-01-01 00:00:00

  • Gonadotropin requirements of the developing follicle.

    abstract:OBJECTIVE:To evaluate follicular FSH and LH requirements during suppression of endogenous gonadotropins with the GnRH antagonist Nal-Glu and whether LH-like activity could be supplied by administering subcutaneous hCG. DESIGN:Randomized clinical trial. PARTICIPANTS:Thirty-two normally cycling females in the late foll...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Thompson KA,LaPolt PS,River J,Henderson G,Dahl KD,Meldrum DR

    更新日期:1995-02-01 00:00:00

  • Protein O-carboxylmethyltransferase in spermatozoa from normal and infertile men.

    abstract::In confirmation of several reports, suspensions of normal washed human spermatozoa exposed to a nonionic detergent exhibited considerable activity of the enzyme protein O-carboxylmethyltransferase (PCM), which catalyzes the methyl esterification of carboxyl groups of dicarboxylic amino acid residues in proteins. Vario...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hatch R,Harvey SE,Williams-Ashman HG

    更新日期:1985-04-01 00:00:00

  • Microsurgical transplantation of nonvascularized segments of the fallopian tube in the rabbit.

    abstract::Microsurgical nonvascularized transplantation of a 1-cm segment of fallopian tube was performed using the rabbit as a model. Autograft experiments showed survival of a 1-cm tubal segment for as long as 10 months postoperatively. Allografts survived equally as well, and one rabbit became pregnant. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Stangel JJ,Davidian MM,Wenof M,Barber HR

    更新日期:1981-08-01 00:00:00

  • Low-dose aspirin in reproductive health: effects on menstrual cycle characteristics.

    abstract:OBJECTIVE:To estimate the effect of daily 81 mg low-dose aspirin (LDA) on menstrual cycle length and hormone profiles. DESIGN:Secondary analysis of a trial evaluating the effect of daily LDA or placebo on live birth among women with one or two previous pregnancy losses. SETTING:University medical centers. PATIENT(S)...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Evans MB,Nobles CJ,Kim K,Hill MJ,DeCherney AH,Silver RM,Mumford SL,Sjaarda LA,Perkins NJ,Schisterman EF

    更新日期:2020-12-01 00:00:00

  • Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis.

    abstract:OBJECTIVE:To investigate types of nerve fibers in endometrium and myometrium in women with endometriosis. DESIGN:Laboratory study using human tissue. SETTING:University-based laboratory. PATIENT(S):Women with and without endometriosis undergoing hysterectomy. INTERVENTION(S):Histologic sections of contiguous endome...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Tokushige N,Markham R,Russell P,Fraser IS

    更新日期:2007-10-01 00:00:00

  • Morphologic abnormalities in 2-year-old children born after in vitro fertilization/intracytoplasmic sperm injection with preimplantation genetic screening: follow-up of a randomized controlled trial.

    abstract:OBJECTIVE:To evaluate the effect of preimplantation genetic screening (PGS) on morphologic outcome in children. DESIGN:Follow-up of a randomized controlled trial (RCT). SETTING:University hospital. PATIENT(S):Two-year-old children born to mothers who participated in an RCT on the efficacy of PGS: 50 children born af...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Beukers F,van der Heide M,Middelburg KJ,Cobben JM,Mastenbroek S,Breur R,van der Lee JH,Hadders-Algra M,Bos AF,Kok JH,PGS Study Group.

    更新日期:2013-02-01 00:00:00

  • Frequency of premature menopause in women who carry a BRCA1 or BRCA2 mutation.

    abstract:OBJECTIVE:To evaluate the impact of carrying a BRCA1 or BRCA2 mutation on the probability of experiencing premature natural menopause. DESIGN:Observational study. SETTING:Patients in an academic research environment. PATIENT(S):Women who carry a BRCA1 or BRCA2 mutation (case subjects) and women who do not carry a mu...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,多中心研究


    authors: Finch A,Valentini A,Greenblatt E,Lynch HT,Ghadirian P,Armel S,Neuhausen SL,Kim-Sing C,Tung N,Karlan B,Foulkes WD,Sun P,Narod S,Hereditary Breast Cancer Study Group.

    更新日期:2013-05-01 00:00:00

  • Triple ultrasound markers including fetal cardiac activity are related to miscarriage risk.

    abstract:OBJECTIVE:To identify early ultrasound markers in pregnant patients that predict a favorable pregnancy outcome. DESIGN:Retrospective case-control study. SETTING:Infertility patients in fertility clinic. PATIENT(S):1051 women with early pregnancies conceived after fertility treatment. INTERVENTION(S):None. MAIN OUT...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Bae S,Karnitis J

    更新日期:2011-11-01 00:00:00

  • Evaluation of risk factors associated with endometriosis.

    abstract:OBJECTIVE:To investigate the association between several factors such as demographics, personal habits, reproductive factors, menstrual characteristics, contraception, and clinical profile and the probability of having endometriosis. SETTING:Ten clinical institutions in the Montreal area. PATIENT(S):A total of 2777 s...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hemmings R,Rivard M,Olive DL,Poliquin-Fleury J,Gagné D,Hugo P,Gosselin D

    更新日期:2004-06-01 00:00:00

  • Immunolocalization of a sperm membrane protein in human male reproductive organs.

    abstract::A monoclonal antibody that induces agglutination of human sperm was used to localize the interacting antigen in various tissues by indirect immunofluorescence. The antibody localized to the immature sperm and Sertoli cells of the seminiferous tubules, simple cuboidal epithelial cells of the rete testis, and the column...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Yan YC,Mitsudo SM,Wang LF,Koide SS

    更新日期:1984-10-01 00:00:00

  • Correlation of the bioactivity of luteinizing hormone in follicular fluid with oocyte maturity in the spontaneous cycle.

    abstract::This study was done to measure the bioactivity of luteinizing hormone (LH) in follicular fluid (FF) and to correlate this and other hormonal values with oocyte maturity in the spontaneous cycle. Twenty follicles (greater than 18 mm) from 18 ovulatory patients were obtained, and FF, according to oocyte maturity, was di...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Cha KY,Barnes RB,Marrs RP,Lobo RA

    更新日期:1986-03-01 00:00:00

  • High expression of luteinizing hormone receptors messenger RNA by human cumulus granulosa cells is in correlation with decreased fertilization.

    abstract:OBJECTIVE:To elucidate the LH receptor (LHR) expression patterns in human granulosa cells (GCs) from antral to preovulatory stages, and to investigate a correlation to oocyte function. DESIGN:Luteinized preovulatory GCs were obtained from preovulatory follicles aspirated during IVF (≥ 17 mm). The GCs from small- (<10 ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Maman E,Yung Y,Kedem A,Yerushalmi GM,Konopnicki S,Cohen B,Dor J,Hourvitz A

    更新日期:2012-03-01 00:00:00